DOTA-NHS-ester Hexafluorophosphate TFA Salt (Technical Grade) Chemical Properties

Melting point:

176-179°C

storage temp. 

Hygroscopic, Refrigerator, under inert atmosphere

solubility 

DMSO (Slightly), Methanol (Slightly, Heated)

form 

Solid

color 

White to Off-White

Appearance

white powder

Stability:

Hygroscopic

InChIKey

NGLVUOKEPPQYJQ-UHFFFAOYSA-O

SMILES

C(F)(F)(F)C(=O)O.[P+5]([F-])([F-])([F-])([F-])([F-])[F-].O(N1C(CCC1=O)=O)C(=O)CN1CCN(CCN(CC(=O)O)CCN(CC(=O)O)CC1)CC(=O)O.[H+]

DOTA-NHS-ester Hexafluorophosphate TFA Salt (Technical Grade) Usage And Synthesis

Description

DOTA (dodecane tetraacetic acid, also known as tetraxetan) is a complexing agent, especially for lanthanide ions. DOTA-NHS ester is a bifunctional linker containing chelating and N-hydroxysuccinimide (NHS) ester groups for conjugation with amine-containing biomolecules.

DOTA-NHS ester can be used to label radiotherapeutic agents or imaging probes and detect labeled tumors with PET, SPECT, and CT methods.

Uses

DOTA-NHS-ester Hexafluorophosphate TFA Salt is used as a reagent in the preparation of metal or radiometal-labeled-urea- and carbamate-based PSMA inhibitors for PSMA-targeted imaging and radiotherapy.

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