Lacnotuzumab
Lacnotuzumab Basic information
- Product Name:
- Lacnotuzumab
- Synonyms:
-
- Lacnotuzumab
- Research Grade Lacnotuzumab
- Lacnotuzumab (anti-M-CSF)
- CAS:
- 1831128-32-5
- MW:
- 0
- Mol File:
- Mol File
Lacnotuzumab Chemical Properties
- form
- Liquid
- color
- Colorless to light yellow
Lacnotuzumab Usage And Synthesis
Uses
Lacnotuzumab (MCS110) is a neutralizing humanized IgG1/κ monoclonal antibody targeting CSF-1 that prevents CSF-1 from activating the CSF-1R. Lacnotuzumab can be used for the research of pigmented villonodular synovitis[1][2].
in vivo
Lacnotuzumab neutralizes recombinant and serum-derived forms of cynomolgus CSF-1, but it does not recognize rodent or rabbit CSF-1[2].
References
[1] Kuemmel S, et, al. A Randomized Phase II Study of Anti-CSF1 Monoclonal Antibody Lacnotuzumab (MCS110) Combined with Gemcitabine and Carboplatin in Advanced Triple-Negative Breast Cancer. Clin Cancer Res. 2022 Jan 1;28(1):106-115. DOI:10.1158/1078-0432.CCR-20-3955
[2] Pognan F, et, al. Colony-Stimulating Factor-1 Antibody Lacnotuzumab in a Phase 1 Healthy Volunteer Study and Mechanistic Investigation of Safety Outcomes. J Pharmacol Exp Ther. 2019 Jun;369(3):428-442. DOI:10.1124/jpet.118.254128
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