Sulfobromophthalein sodium CAS#: 123359-42-2

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Sulfobromophthalein sodium

Basic information Safety Supplier Related

Sulfobromophthalein sodium Basic information

Product Name:

Sulfobromophthalein sodium

Synonyms:

BROMOSULFOPHTHALEIN
BROMOSULFOPHTHALEIN SODIUM SALT
BROMO SULPHALEIN
BROMOSULPHALEIN DISODIUM SALT
3,3'-(4,5,6,7-tetrabromo-3-oxo-1(3h)-isobenzofuranylidene)bis(6-hydroxy-benzenesulfonic acid) disodium salt
bromsulfalein sodium
SULFORBROMOPHTHALEINSODIUMHYDRATE
PHENOLTETRABROMOPHTHALEIN-3',3''-DISULFONIC ACID DISODIUM SALT

CAS:

123359-42-2

MF:

C20H13Br4NaO11S2

MW:

836.04

EINECS:

626-376-1

Mol File:

123359-42-2.mol

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Sulfobromophthalein sodium Chemical Properties

Melting point:: >235°C (dec.)
storage temp.: room temp
solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form: Crystalline Powder
color: White
CAS DataBase Reference: 123359-42-2(CAS DataBase Reference)

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Safety Information

Hazard Codes: Xn
Risk Statements: 42/43-R42/43
Safety Statements: 22-36/37-45-S45-S36/37-S22
WGK Germany: 3
RTECS: SM8395000
HS Code: 29329900

MSDS

Language:English Provider:SigmaAldrich

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Sulfobromophthalein sodium Usage And Synthesis

Description

A blue dye used in the assessment of hepatobiliary dysfunction. The concentration in plasma is monitored since dye removal from the blood is delayed in hepatic dysfunction. Experimentally the appearance of sulfobromphthalein in the bile can also be measured.

Chemical Properties

White, crystalline powder; odorless; bit- ter taste. Hygroscopic; soluble in water; insoluble in alcohol and acetone.

Uses

Medicine (diagnostic aid).

Uses

Sulfobromophthalein disodium salt hydrate has been used as a positive control to study the interaction of 11-keto-β-boswellic acid (KBA) and 3-acetyl-11-keto-β-boswellic acid (AKBA) with organic anion transporter OATP1B3.

Biochem/physiol Actions

Sulfobromophthalein (BSP) is a high affinity organic ion substrate for organic anion transporting polypeptides (OATPs) and has been used as a substrate for multidrug resistance associated protein 2 (Mrp2). BSP is transported into hepatocytes by OATPs and, after conjugation to glutathione, is excreted into bile by Mrp2. It was found to inhibit the aldo-keto reductase ARK1C20.

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