oxycinchophen Chemical Properties

Melting point:

206.5°C (rough estimate)

Boiling point:

408.48°C (rough estimate)

Density 

1.1861 (rough estimate)

refractive index 

1.5300 (estimate)

storage temp. 

2-8°C

pka

0.55±0.10(Predicted)

color 

Minute, deep yellow prisms from alc

Safety Information

Toxicity

LD50 orl-dog: >5 mg/kg PEMNDP 9,643,91

oxycinchophen Usage And Synthesis

Uses

Oxicinchophen has bene used to study P-selectin antagonistic activity, DHOD inhibitory activity, SAR of quinoline salicylic acids using Pfitzinger reaction of isatin derivatives with (acetyloxy)acetophenone derivatives; effect of antiinflammatory drugs on vascular smooth muscle; increase in oxygen consumption in the absence of a phosphate acceptor and to inhibit ATP synthesis in the isolated rat liver mitochondria.

Definition

ChEBI: Oxycinchophen is a member of quinolines.

Safety Profile

Low toxicity by ingestion and skin contact. When heated to decomposition it emits toxic fumes of NOx.

Purification Methods

It is precipitated from alkaline solution on acidification and crystallises from EtOH or AcOH in yellow crystals. [Marshall & Blanchard J Pharmacol 95 186 1949, Beilstein 22 H 245, 22 II 183, 22 III/IV 2383.]

oxycinchophen(485-89-2)Related Product Information

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