2-METHYL-4-HYDROXYMETHYLPYRIDINE Chemical Properties

Boiling point:

131-140 °C(Press: 4 Torr)

Density 

1.092±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Room Temperature

pka

13.46±0.10(Predicted)

form 

powder

color 

Pale yellow

Safety Information

Hazard Codes 

Xn

Risk Statements 

20/21/22-36/37/38

Safety Statements 

26-36

HS Code 

2933399990

2-METHYL-4-HYDROXYMETHYLPYRIDINE Usage And Synthesis

Synthesis Reference(s)

Synthesis, p. 483, 2002 DOI: 10.1055/s-2002-20960

Synthesis

General procedure for the synthesis of 2-methyl-4-hydroxymethylpyridine from (2-chloro-6-methylpyridin-4-yl)methanol: In a variant of the method described above, 2-chloro-6-methylpyridine-4-carboxylic acid, palladium catalyst (0.20 g, 10 mol% loaded on carbon), ethyl acetate (45 mL) and triethylamine (2.8 mL, 20 mmol) were mixed. The reaction mixture was placed under a hydrogen atmosphere at 1 atmosphere for 21 hours. Subsequently, additional Pearlman catalyst (0.2 g) was added and the reaction continued to be stirred for 5 hours under a hydrogen atmosphere to achieve dechlorination. Upon completion of the reaction, the mixture was filtered through a diatomaceous earth pad and the filtrate was concentrated. Purification by column chromatography (eluent ratio 5:95 methanol:dichloromethane) afforded (2-methylpyridin-4-yl)methanol (1.48 g, 88% yield). The obtained (2-methylpyridin-4-yl)methanol can be used to prepare 2-amino-3-(2-methylpyridin-4-yl)propionitrile, and 1-methyl-1H-indol-2-one carboxylic acid ((1S,2R)-2-{[cyano -(2-methylpyridin-4-ylmethyl)-methyl]-carbamoyl}-cyclohexyl)amide obtained by the method described above (186 mg, yield 62%). Results of mass spectrometry analysis: m/z 444 (M+H).

References

[1] Patent: US2004/77646, 2004, A1. Location in patent: Page 116

2-METHYL-4-HYDROXYMETHYLPYRIDINE(105250-16-6)Related Product Information

• 2,2'-BIQUINOLINE-4,4'-DICARBOXYLIC ACID DIPOTASSIUM SALT TRIHYDRATE
• 3-Hydroxy-2-methyl-4-quinolinecarboxylic acid
• 4-Pyridoxic acid
• Pyridoxine hydrochloride
• CINCHOPHEN
• Bicinchoninic Acid Disodium Salt
• 2,4-Pyridinedicarboxylic acid
• ETHYL 2-CHLORO-3-CYANO-6-METHYLISONICOTINATE
• 2,2'-Bipyridine-4,4'-dicarboxylic acid
• oxycinchophen
• Pyridoxine
• Pyrroloquinoline quinone
• 6-CHLORO-2-(4-CHLOROPHENYL)-4-QUINOLINE CARBOXYLIC ACID
• Dimethyl 2,4-pyridinedicarboxylate
• 2-PHENYL-QUINOLINE-4-CARBOXYLIC ACID METHYL ESTER
• 6-METHOXY-2-PHENYL-4-QUINOLINECARBOXYLIC ACID
• NEOCINCHOPHEN
• 2-(3-CARBOXY-4-HYDROXYPHENYL) QUINOLINE-4-CARBOXYLIC ACID