- Product Name:
- 2-Picoline-4,5-dimethanol, 3-hydroxy-
- 3,4-Pyridinedimethanol, 5-hydroxy-6-methyl-
- Product Categories:
- Heterocycle-Pyridine series
- vitamin series
- Mol File:
Pyridoxine Chemical Properties
- Melting point:
- 214-215 °C(lit.)
- Boiling point:
- 298.46°C (rough estimate)
- 1.2435 (rough estimate)
- refractive index
- 1.5100 (estimate)
- storage temp.
- H2O: 0.1 g/mL at 20 °C, clear, colorless
- pKa 5.00(H2O t = 25.0 I = 0.15 (mixed)) (Uncertain)
- Stable. Incompatible with strong oxidizing agents.
- CAS DataBase Reference
- 65-23-6(CAS DataBase Reference)
- NIST Chemistry Reference
- EPA Substance Registry System
- 3,4-Pyridinedimethanol, 5-hydroxy-6-methyl- (65-23-6)
Pyridoxine Usage And Synthesis
Pyridoxine hydrochloride provides pyridoxine, which is also known as vitamin B6. Vitamin B6 is naturally found in foods such as cereals, beans, vegetables, liver, meat, and eggs. Vitamin B6 functionalizes as a coenzyme in the metabolism of protein, carbohydrate, and fat. Vitamin 6 is needed to maintain the health of nerves, skin, and red blood cells.
Pyridoxine is used to prevent or treat vitamin B6 deficiency caused by inadequate dietary intake. It is also used to treat drug induced deficiency in patients taking isoniazid or oral contraceptives.
Vitamin B6 (pyridoxine) is a water-soluble vitamin used in the prophylaxis and treatment of vitamin B6 deficiency and peripheral neuropathy in those receiving isoniazid (isonicotinic acid hydrazide, INH). Vitamin B6 has been found to lower systolic and diastolic blood pressure in a small group of subjects with essential hypertension. Hypertension is another risk factor for atherosclerosis and coronary heart disease. Another study showed pyridoxine hydrochloride to inhibit ADP- or epinephrine-induced platelet aggregation and to lower total cholesterol levels and increase HDL-cholesterol levels, again in a small group of subjects. Vitamin B6, in the form of pyridoxal 5'-phosphate, was found to protect vascular endothelial cells in culture from injury by activated platelets. Endothelial injury and dysfunction are critical initiating events in the pathogenesis of atherosclerosis.
Oral Rat LD50 = 4 gm/kg. Toxic effects include convulsions, dyspnea, hypermotility, diarrhea, ataxia and muscle weakness.
pyridoxine HCL is a skin-conditioning agent that is also widely used in hair products.
Vitamin B6, a water-soluble vitamin with a solubility of 1 g in 5 ml of water. It functions in the utilization of protein and is an essential nutrient in enzyme reactions. It is necessary for proper growth. During processing, there is a loss due to leaching of the vitamin in water. It is destroyed by high temperatures, high irradiation, and exposure to light. During storage, loss increases with temperature and storage time. It is found in liver, eggs, and meats.
ChEBI: A hydroxymethylpyridine with hydroxymethyl groups at positions 4 and 5, a hydroxy group at position 3 and a methyl group at position 2. The 4-methanol form of vitamin B6, it is converted intoto pyridoxal phosphate which is a coenzyme f r synthesis of amino acids, neurotransmitters, sphingolipids and aminolevulinic acid.
World Health Organization (WHO)
Pyridoxine (vitamin B6) is listed in theWHO Model List of Essential Drugs.
The discovery of vitamin B6 is generally ascribed to Paul Gy?rgy who first realized there was a vitamin that was distinctly different from vitamin B2 in 1934. Pyridoxine (PN) is the C4 hydroxymethyl derivative, pyridoxal (PL) is the C4 formyl derivative and pyridoxamine (PM) is the C4 aminomethyl derivative of 5-(hydroxymethyl)- 2-methylpyridin-3-ol). Each of these are also converted to their corresponding 5'-phosphate derivatives referred to as pyridoxine 5'-phosphate (PNP), pyridoxal 5'-phosphate (PLP), and pyridoxamine 5'-phosphate (PMP), respectively . Because of their ability to interconvert, all are considered active forms of vitamin B6 in vivo. Although PLP is the major coenzyme form, PMP can also function as a coenzyme primarily in aminotransferases. The major metabolite is 4-pyridoxic acid, which is excreted in the urine.
Pyridoxine is indicated in the treatment and prevention of known or suspected vitamin B6 deficiency, which is most likely to occur in the setting of alcoholism in developed countries. At least seven genetic disorders that result in a vitamin B6 deficiency syndrome in the presence of an adequate dietary intake have been identified. These result from defects in enzymes that are responsible for the bioactivation or utilization of vitamin B6.
Moderately toxic by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects: ataxia, local anesthetic, paresthesia. When heated to decomposition it emits toxic fumes of Nox
Veterinary Drugs and Treatments
Pyridoxine use in veterinary medicine is relatively infrequent. It
may be of benefit in the treatment of isoniazid (INH) or crimidine
(an older rodenticide) toxicity. Pyridoxine deficiency is apparently
extremely rare in dogs or cats able to ingest food. Cats with severe
intestinal disease may have a greater requirement for pyridoxine in
their diet. Experimentally, pyridoxine has been successfully used
in dogs to reduce the cutaneous toxicity associated with doxorubicin
containing pegylated liposomes (Doxil?). Pyridoxine has been
demonstrated to suppress the growth of feline mammary tumors
(cell line FRM) in vitro.
In humans, labeled uses for pyridoxine include pyridoxine deficiency and intractable neonatal seizures secondary to pyridoxine dependency syndrome. Unlabeled uses include premenstrual syndrome (PMS), carpal tunnel syndrome, tardive dyskinesia secondary to antipsychotic drugs, nausea and vomiting in pregnancy, hyperoxaluria type 1 and oxalate kidney stones, and for the treatment of isoniazid (INH), cycloserine, hydrazine or Gyometra mushroom poisonings.
Pyridoxine Preparation Products And Raw materials
- 001-857-928-2050 or 1-888-588-9418
- 021-54306202- ;021-54308259-
- Methyl acrylate
- Methyl bromide
- CHLOROPHOSPHONAZO III
- 2,2-Bis(hydroxymethyl)butyric acid
- PYRIDOXINE HYDROCHLORIDE pure,Adermine hydrochloride, PN HCl, Pyridoxine hydrochloride, Pyridoxol hydrochloride, VitaminB6 hydrochloride,Pyridoxine hydrochloride, 99.0%, extra pure,Pyridoxine hydrochloride, extra pure,Pyridoxine hydrochloride >99.5%,Pyridoxine hydrochloride,Pyridoxine hydrochloride, extra pure, 99.0%,pyridoxine hydrochloride (b6),VitaminB6.HCl/Pyridoxine.HClHCl,Pyridoxine HCl USP
- METSULFURON METHYL