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2,4-Lutidine

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2,4-Lutidine Basic information

Product Name:
2,4-Lutidine
Synonyms:
  • 2,4-LUTIDINE 98+%
  • 2,4-DIMETHYLPYRIDINE(2,4-LUTIDINE)
  • Dimethylpyridine, 2,4-: (2,4-Lutidine)
  • 2,4-Lutidine, 98+% 500ML
  • 2,4-DIMETHYLPYRIDINE FOR SYNTHESIS
  • 2,4-Lutidine 99%
  • alpha,gamma-Dimethylpyridine
  • Pyridine,2,4-dimethyl-
CAS:
108-47-4
MF:
C7H9N
MW:
107.15
EINECS:
203-586-8
Product Categories:
  • Building Blocks
  • C7
  • Biochemistry
  • Chemical Synthesis
  • Heterocyclic Building Blocks
  • Pyridines
  • Organics
  • Heterocyclic Compounds
  • Reagents for Oligosaccharide Synthesis
Mol File:
108-47-4.mol
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2,4-Lutidine Chemical Properties

Melting point:
-60 °C (lit.)
Boiling point:
159 °C (lit.)
Density 
0.927 g/mL at 25 °C (lit.)
FEMA 
4389 | 2,4-DIMETHYLPYRIDINE
refractive index 
n20/D 1.499(lit.)
Flash point:
99 °F
storage temp. 
Flammables area
solubility 
350g/l
pka
6.99(at 25℃)
Water Solubility 
15 g/100 mL (20 ºC)
Sensitive 
Hygroscopic
JECFA Number
2151
BRN 
1506
InChIKey
JYYNAJVZFGKDEQ-UHFFFAOYSA-N
CAS DataBase Reference
108-47-4(CAS DataBase Reference)
NIST Chemistry Reference
Pyridine, 2,4-dimethyl-(108-47-4)
EPA Substance Registry System
2,4-Dimethylpyridine (108-47-4)
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Safety Information

Hazard Codes 
T,F,Xi
Risk Statements 
10-23/24/25-36/37/38-25-20/21-20/21/22
Safety Statements 
16-26-36/37/39-45
RIDADR 
UN 1992 3/PG 3
WGK Germany 
3
RTECS 
OK9400000
8
TSCA 
Yes
HazardClass 
3
PackingGroup 
III
HS Code 
29333999

MSDS

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2,4-Lutidine Usage And Synthesis

Chemical Properties

Clear pale yellow liquid, discoloring over time

Chemical Properties

Colorless to pale-yellow clear liquid.

Aroma threshold values

High strength odor, recommend smelling in a 0.01% solution or less.

Purification Methods

Dry it with Linde type 5A molecular sieves, BaO or sodium, and fractionally distil it. The distillate (200g) is heated with *benzene (500mL) and conc HCl (150mL) in a Dean and Stark apparatus on a water bath until water no longer separates, and the temperature just below the liquid reaches 80o. When cold, the supernatant *benzene is decanted, and the 2,4-lutidine hydrochloride, after washing with a little *benzene, is dissolved in water (350mL). After removing any *benzene by steam distillation, an aqueous solution of NaOH (80g) is added, and the free lutidine is steam distilled. It is isolated by saturating the distillate with solid NaOH and distilling it through a short column. The precipitation cycle is repeated, then the final distillate is partly frozen in an apparatus at -67.8-68.5o (cooled by acetone/CO2). The crystals are collected, then melted and distilled. [Kyte et al. J Chem Soc 4454 1960.] Alternative purifications are via the picrate m 183-184o (from H2O). [Clarke & Rothwell J Chem Soc 1885 1960], or the hydrobromide [Warnhoff J Org Chem 27 4587 1962]. The latter is precipitated from a solution of lutidine in *benzene by passing dry HBr gas: the salt is recrystallised from CHCl3/methyl ethyl ketone, then decomposed with NaOH, and the free base is extracted into Et2O, dried, evaporated and the residue is distilled. [Beilstein 20 H 244, 20 II 180, 20 III/IV 2718, 20/6 V 19.]

2,4-LutidineSupplier

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