2,4-Lutidine Chemical Properties

Melting point:

-60 °C (lit.)

Boiling point:

159 °C (lit.)

Density 

0.927 g/mL at 25 °C (lit.)

vapor pressure 

3.28hPa at 25℃

FEMA 

4389 | 2,4-DIMETHYLPYRIDINE

refractive index 

n20/D 1.499(lit.)

Flash point:

99 °F

storage temp. 

Flammables area

solubility 

350g/l

form 

Liquid

pka

6.99(at 25℃)

color 

Colorless to Light yellow to Light orange

Odor

at 0.01 % in dipropylene glycol. smoky phenolic

Odor Type

smoky

Water Solubility 

15 g/100 mL (20 ºC)

Sensitive 

Hygroscopic

JECFA Number

2151

BRN 

1506

Dielectric constant

9.5999999999999996

InChIKey

JYYNAJVZFGKDEQ-UHFFFAOYSA-N

LogP

1.9

CAS DataBase Reference

108-47-4(CAS DataBase Reference)

NIST Chemistry Reference

Pyridine, 2,4-dimethyl-(108-47-4)

EPA Substance Registry System

2,4-Dimethylpyridine (108-47-4)

Safety Information

Hazard Codes 

T,F,Xi

Risk Statements 

10-23/24/25-36/37/38-25-20/21-20/21/22

Safety Statements 

16-26-36/37/39-45

RIDADR 

UN 1992 3/PG 3

WGK Germany 

3

RTECS 

OK9400000

F 

8

TSCA 

Yes

HazardClass 

3

PackingGroup 

III

HS Code 

29333999

MSDS

• Language:English Provider:2,4-Lutidine
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2,4-Lutidine Usage And Synthesis

Chemical Properties

Clear pale yellow liquid, discoloring over time

Chemical Properties

Colorless to pale-yellow clear liquid.

Uses

2,4-Lutidine, can be used as a building block in the synthesis of various chemical compounds. It is also used tobacco and aroma component.

Definition

ChEBI: 2,4-Dimethylpyridine is a member of methylpyridines.

Aroma threshold values

High strength odor, recommend smelling in a 0.01% solution or less.

Purification Methods

Dry it with Linde type 5A molecular sieves, BaO or sodium, and fractionally distil it. The distillate (200g) is heated with *benzene (500mL) and conc HCl (150mL) in a Dean and Stark apparatus on a water bath until water no longer separates, and the temperature just below the liquid reaches 80o. When cold, the supernatant *benzene is decanted, and the 2,4-lutidine hydrochloride, after washing with a little *benzene, is dissolved in water (350mL). After removing any *benzene by steam distillation, an aqueous solution of NaOH (80g) is added, and the free lutidine is steam distilled. It is isolated by saturating the distillate with solid NaOH and distilling it through a short column. The precipitation cycle is repeated, then the final distillate is partly frozen in an apparatus at -67.8-68.5o (cooled by acetone/CO2). The crystals are collected, then melted and distilled. [Kyte et al. J Chem Soc 4454 1960.] Alternative purifications are via the picrate m 183-184o (from H2O). [Clarke & Rothwell J Chem Soc 1885 1960], or the hydrobromide [Warnhoff J Org Chem 27 4587 1962]. The latter is precipitated from a solution of lutidine in *benzene by passing dry HBr gas: the salt is recrystallised from CHCl3/methyl ethyl ketone, then decomposed with NaOH, and the free base is extracted into Et2O, dried, evaporated and the residue is distilled. [Beilstein 20 H 244, 20 II 180, 20 III/IV 2718, 20/6 V 19.]

2,4-Lutidine(108-47-4)Related Product Information

• 2-Chloro-3-cyanopyridine
• 2,6-Lutidine
• Poly(dimethylsiloxane)
• Dimethyl sulfoxide
• N,N-Dimethylformamide
• N,N-Dimethylacetamide
• Dimethyl sulfone
• Pyridoxine
• 4-Pyridoxic acid
• 3,4-Lutidine98%,3,4-LUTIDINE 98%,3,4-LUTIDINE 3,4-DIMETHYLPYRIDINE
• 2,4,6-Collidine
• Bathocuproine
• 3-(4-PHENYL-2-PYRIDYL)-5-PHENYL-1,2,4-TRIAZINE DISULFONIC ACID, DISODIUM SALT
• 2,5-LUTIDINE 98+%
• 3,5-Lutidine,99%,Lutidine,98%,3,5-LUTIDINE, 98+%,3,5-LUTIDINE 3,5-DIMETHYLPYRIDINE,3 5-LUTIDINE STANDARD FOR GC
• 4,4'-Dimethyl-2,2'-bipyridyl
• 2,4-DIMETHYLQUINOLINE
• 2,3-LUTIDINE,2,3-DIMETHYLPYRIDINE(2,3-LUTIDINE),2,3-LUTIDINE 98+%,2,3-Lutidine,99%,2,3-LUTIDINE/2,3-DIMETHYL PYRIDINE