2-Amino-4,6-dimethylpyridine Chemical Properties

Melting point:

63-64 °C (lit.)

Boiling point:

235 °C (lit.)

Density 

1.0959 (rough estimate)

refractive index 

1.6100 (estimate)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

pka

7.62±0.35(Predicted)

form 

Crystalline Powder

color 

White to light brown

InChI

InChI=1S/C7H10N2/c1-5-3-6(2)9-7(8)4-5/h3-4H,1-2H3,(H2,8,9)

InChIKey

BRBUBVKGJRPRRD-UHFFFAOYSA-N

SMILES

C1(N)=NC(C)=CC(C)=C1

CAS DataBase Reference

5407-87-4(CAS DataBase Reference)

NIST Chemistry Reference

2-Pyridinamine, 4,6-dimethyl-(5407-87-4)

EPA Substance Registry System

2-Pyridinamine, 4,6-dimethyl- (5407-87-4)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-22

Safety Statements 

26-37/39

WGK Germany 

3

RTECS 

US1818000

Hazard Note 

Irritant

HS Code 

2933399990

MSDS

• Language:English Provider:SigmaAldrich

2-Amino-4,6-dimethylpyridine Usage And Synthesis

Chemical Properties

White to off-white crystalline

Uses

Organic intermediate.

Uses

2-Amino-4,6-dimethylpyridine, can be used in the synthesis of various chemical compounds having therapeutic activity, such as in preparation of quinoline and quinoxaline compounds having anticancer activity.

Application

2-Amino-4,6-dimethylpyridine is a nonsteroidal anti-inflammatory drug that inhibits the production of prostaglandins and leukotrienes. 2-Amino-4,6-dimethylpyridine binds to the cyclooxygenase enzyme and blocks its conversion of arachidonic acid to prostaglandin H2. This compound has been shown to have potent inhibitory effects against Leishmania, with high values in reactive compounds. The molecular modeling of this compound shows that it has an unpaired amino function and an amide.

Purification Methods

Recrystallise this base from hexane, ether/pet ether or *benzene. Residual *benzene is removed over paraffin-wax chips in an evacuated desiccator. The dipicrate crystallises from EtOH and has m 205-207o(dec). [Beilstein 22 III/IV 4210.]

2-Amino-4,6-dimethylpyridine(5407-87-4)Related Product Information

• Tris(hydroxymethyl)aminomethane
• N,N-Dimethyl-1,4-phenylenediamine
• 3-Aminopyridine
• 2,4-Lutidine
• 2,6-Lutidine
• 2-Amino-3-picoline
• 4-Dimethylaminopyridine
• Glycine
• 4-Methylpyridin-2-amine
• 2-Amino-6-methylpyridine
• 3-Aminophenol
• 6-Aminocaproic acid
• 2-Aminopyridine
• 2-Amino-5-methylpyridine
• ALTRENOGEST
• 2-Amino-4,6-dimethylpyrimidine
• 5,7-DIMETHYLPYRIDO[2,3-D]PYRIMIDIN-4(3H)-ONE
• 2-AMINO-4,6-DIMETHYLPYRIDINE-3-CARBOXAMIDE,2-AMINO-4,6-DIMETHYLPYRIDINE-3-CARBOXAMI