4-Methylpyridin-2-amine Chemical Properties

Melting point:

96-99 °C (lit.)

Boiling point:

230 °C (lit.)

Density 

1.0275 (estimate)

vapor pressure 

3.71Pa at 25℃

refractive index 

1.5560 (estimate)

Flash point:

118 °C

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

DMF: freely soluble

form 

Flakes

pka

pK1: 7.48(+1) (25°C)

color 

Slightly yellow to beige or brown

Water Solubility 

SOLUBLE

Sensitive 

Hygroscopic

Merck 

14,466

BRN 

107066

LogP

0.56-1.08

CAS DataBase Reference

695-34-1(CAS DataBase Reference)

NIST Chemistry Reference

2-Pyridinamine, 4-methyl-(695-34-1)

EPA Substance Registry System

2-Pyridinamine, 4-methyl- (695-34-1)

Safety Information

Hazard Codes 

T

Risk Statements 

45-46-60-61-8-21-25-26-34-42/43-48/23-50/53-36/37/38-33-23/24/25

Safety Statements 

53-45-60-61-37/39-28A-26-36/37/39

RIDADR 

UN 3086 6.1/PG 1

WGK Germany 

3

RTECS 

TJ5150000

TSCA 

Yes

HazardClass 

6.1

PackingGroup 

II

HS Code 

29333999

Toxicity

LD50 oral in rat: 200mg/kg

MSDS

• Language:English Provider:4-Methylpyridin-2-amine
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
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4-Methylpyridin-2-amine Usage And Synthesis

Chemical Properties

Light yellow to brown flakes

Uses

Intermediate, medicine.

Uses

2-Amino-4-methylpyridine has been used in the synthesis of 2-amino-4-methyl-pyridinium 2-hy-droxy-benzoate. It is potent inhibitor of NOS2 (iNOS) in vitro. It is used as pharmaceutical intermediate.

Synthesis Reference(s)

The Journal of Organic Chemistry, 72, p. 4554, 2007 DOI: 10.1021/jo070189y

General Description

2-Amino-4-methylpyridine acts as ligand and forms methoxo-bridged copper(II) complexes.

Biochem/physiol Actions

2-Amino-4-methylpyridine inhibits the activity of inducible NO synthase isolated from mouse RAW 264.7 cells in vitro.

Synthesis

A mixture of 2-amino-3-chloro-4-methylpyridine 0.96 g (0. 0067πο1) and benzoic acid, 1.83 g (0.015 mol) was added, the copper powder was added, reacted at 150 ° C for 1 h, and the reaction solution was added to water, Adding the decolorizer, adjusting the pH of the filtered solution to pH 9, filtering and drying the filter cake to obtain 0.65 g of crude 4-Methylpyridin-2-amine as a yellow solid, the yield was 89.3percent. The crude 0.65g dissolved in dilute hydrochloric acid solution to the crude product completely dissolved to obtain a salt solution, adding ethyl acetate to the salt solution to extract the water phase, slowly adding sodium bicarbonate to the aqueous phase Solution to pH 9, the solid was completely precipitated, filtered, and the filtrate was washed with distilled water and dried in vacuo to give 0.53 g of 4-Methylpyridin-2-amine as a pale yellow solid.

Purification Methods

Crystallise it from EtOH or a 2:1 *benzene/acetone mixture, and dry it under vacuum as in the prevous entry. [Beilstein 22/9 V 325.]

4-Methylpyridin-2-amine(695-34-1)Related Product Information

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