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4-Methylpyridin-2-amine

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4-Methylpyridin-2-amine Basic information

Product Name:
4-Methylpyridin-2-amine
Synonyms:
  • 2-amino-4-methyl-pyridin
  • 2-amino-4-picolin
  • 2-Amino-gamma-picoline
  • 2-Aminop-4-picoline
  • 2-Pyridinamine,4-methyl-
  • w45
  • w45raschig
  • 4-METHYL-2-PYRIDYLAMINE
CAS:
695-34-1
MF:
C6H8N2
MW:
108.14
EINECS:
211-780-9
Product Categories:
  • amine
  • Amines
  • Pyridines derivates
  • Aromatics
  • Heterocycles
  • Miscellaneous Reagents
  • VARIOUSAMINE
  • FINE Chemical & INTERMEDIATES
  • Pyridine
  • Pyridines, Pyrimidines, Purines and Pteredines
  • Pyridines
  • bc0001
Mol File:
695-34-1.mol
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4-Methylpyridin-2-amine Chemical Properties

Melting point:
96-99 °C (lit.)
Boiling point:
230 °C (lit.)
Density 
1.0275 (estimate)
vapor pressure 
3.71Pa at 25℃
refractive index 
1.5560 (estimate)
Flash point:
118 °C
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
DMF: freely soluble
form 
Flakes
pka
pK1: 7.48(+1) (25°C)
color 
Slightly yellow to beige or brown
Water Solubility 
SOLUBLE
Sensitive 
Hygroscopic
Merck 
14,466
BRN 
107066
LogP
0.56-1.08
CAS DataBase Reference
695-34-1(CAS DataBase Reference)
NIST Chemistry Reference
2-Pyridinamine, 4-methyl-(695-34-1)
EPA Substance Registry System
2-Pyridinamine, 4-methyl- (695-34-1)
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Safety Information

Hazard Codes 
T
Risk Statements 
45-46-60-61-8-21-25-26-34-42/43-48/23-50/53-36/37/38-33-23/24/25
Safety Statements 
53-45-60-61-37/39-28A-26-36/37/39
RIDADR 
UN 3086 6.1/PG 1
WGK Germany 
3
RTECS 
TJ5150000
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
II
HS Code 
29333999
Toxicity
LD50 oral in rat: 200mg/kg

MSDS

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4-Methylpyridin-2-amine Usage And Synthesis

Chemical Properties

Light yellow to brown flakes

Uses

Intermediate, medicine.

Uses

2-Amino-4-methylpyridine has been used in the synthesis of 2-amino-4-methyl-pyridinium 2-hy-droxy-benzoate. It is potent inhibitor of NOS2 (iNOS) in vitro. It is used as pharmaceutical intermediate.

Synthesis Reference(s)

The Journal of Organic Chemistry, 72, p. 4554, 2007 DOI: 10.1021/jo070189y

General Description

2-Amino-4-methylpyridine acts as ligand and forms methoxo-bridged copper(II) complexes.

Biochem/physiol Actions

2-Amino-4-methylpyridine inhibits the activity of inducible NO synthase isolated from mouse RAW 264.7 cells in vitro.

Purification Methods

Crystallise it from EtOH or a 2:1 *benzene/acetone mixture, and dry it under vacuum as in the prevous entry. [Beilstein 22/9 V 325.]

4-Methylpyridin-2-amine Preparation Products And Raw materials

Preparation Products

2-BROMO-3-IODO-ISONICOTINIC ACID2-CHLORO-3-HYDROXYISONICOTINIC ACID2-AMINO-ISONICOTINIC ACID HYDRAZIDE2-AMINO-ISONICOTINIC ACID ETHYL ESTER2-ACETAMIDO-5-BROMOISONICOTINIC ACID2-Nitropyridine-4-carboxylic acid(2-AMINO-PYRIDIN-4-YL)-METHANOL2-AMINO-5-FLUORO-4-PICOLINE2-Aminoisonicotinic acid 2-Fluoroisonicotinic acid2-(2,2-DIMETHYL-PROPIONYLAMINO)-ISONICOTINIC ACID4-Pyridinecarbonyl chloride, 2-fluoro- (9CI)2-AMINO-3,5-DICHLORO-4-METHYLPYRIDINE2-ACETAMIDO-5-AMINO-4-PICOLINE2-ACETAMIDO-5-NITRO-4-PICOLINE2-HYDROXY-4-PYRIDINECARBOXALDEHYDE2-ACETAMIDO-4-METHYL-5-BROMOPYRIDINE2-Amino-5-nitro-4-picoline2-Acetylamino-4-methylpyridine2-Amino-5-bromo-4-methylpyridine

4-Methylpyridin-2-amineSupplier

Jinan Dexinjia Biological Technology Co., Ltd Gold
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J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
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Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
18621169107
Email
market03@meryer.com
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