ChemicalBook > Product Catalog > Pharmaceutical intermediates > Heterocyclic compound > Pyridine compound > Methylpyridine > 4-Methylpyridin-2-amine
4-Methylpyridin-2-amine
4-Methylpyridin-2-amine Basic information
- Product Name:
- 4-Methylpyridin-2-amine
- Synonyms:
-
- 2-amino-4-methyl-pyridin
- 2-amino-4-picolin
- 2-Amino-gamma-picoline
- 2-Aminop-4-picoline
- 2-Pyridinamine,4-methyl-
- w45
- w45raschig
- 4-METHYL-2-PYRIDYLAMINE
- CAS:
- 695-34-1
- MF:
- C6H8N2
- MW:
- 108.14
- EINECS:
- 211-780-9
- Product Categories:
-
- amine
- Amines
- Pyridines derivates
- Aromatics
- Heterocycles
- Miscellaneous Reagents
- VARIOUSAMINE
- FINE Chemical & INTERMEDIATES
- Pyridine
- Pyridines, Pyrimidines, Purines and Pteredines
- Pyridines
- bc0001
- Mol File:
- 695-34-1.mol
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4-Methylpyridin-2-amine Chemical Properties
- Melting point:
- 96-99 °C (lit.)
- Boiling point:
- 230 °C (lit.)
- Density
- 1.0275 (estimate)
- vapor pressure
- 3.71Pa at 25℃
- refractive index
- 1.5560 (estimate)
- Flash point:
- 118 °C
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- DMF: freely soluble
- form
- Flakes
- pka
- pK1: 7.48(+1) (25°C)
- color
- Slightly yellow to beige or brown
- Water Solubility
- SOLUBLE
- Sensitive
- Hygroscopic
- Merck
- 14,466
- BRN
- 107066
- LogP
- 0.56-1.08
- CAS DataBase Reference
- 695-34-1(CAS DataBase Reference)
- NIST Chemistry Reference
- 2-Pyridinamine, 4-methyl-(695-34-1)
- EPA Substance Registry System
- 2-Pyridinamine, 4-methyl- (695-34-1)
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Safety Information
- Hazard Codes
- T
- Risk Statements
- 45-46-60-61-8-21-25-26-34-42/43-48/23-50/53-36/37/38-33-23/24/25
- Safety Statements
- 53-45-60-61-37/39-28A-26-36/37/39
- RIDADR
- UN 3086 6.1/PG 1
- WGK Germany
- 3
- RTECS
- TJ5150000
- TSCA
- Yes
- HazardClass
- 6.1
- PackingGroup
- II
- HS Code
- 29333999
- Toxicity
- LD50 oral in rat: 200mg/kg
MSDS
- Language:English Provider:4-Methylpyridin-2-amine
- Language:English Provider:ACROS
- Language:English Provider:SigmaAldrich
- Language:English Provider:ALFA
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4-Methylpyridin-2-amine Usage And Synthesis
Chemical Properties
Light yellow to brown flakes
Uses
Intermediate, medicine.
Uses
2-Amino-4-methylpyridine has been used in the synthesis of 2-amino-4-methyl-pyridinium 2-hy-droxy-benzoate. It is potent inhibitor of NOS2 (iNOS) in vitro. It is used as pharmaceutical intermediate.
Synthesis Reference(s)
The Journal of Organic Chemistry, 72, p. 4554, 2007 DOI: 10.1021/jo070189y
General Description
2-Amino-4-methylpyridine acts as ligand and forms methoxo-bridged copper(II) complexes.
Biochem/physiol Actions
2-Amino-4-methylpyridine inhibits the activity of inducible NO synthase isolated from mouse RAW 264.7 cells in vitro.
Purification Methods
Crystallise it from EtOH or a 2:1 *benzene/acetone mixture, and dry it under vacuum as in the prevous entry. [Beilstein 22/9 V 325.]
4-Methylpyridin-2-amine Preparation Products And Raw materials
Preparation Products
2-BROMO-3-IODO-ISONICOTINIC ACID2-CHLORO-3-HYDROXYISONICOTINIC ACID2-AMINO-ISONICOTINIC ACID HYDRAZIDE2-AMINO-ISONICOTINIC ACID ETHYL ESTER2-ACETAMIDO-5-BROMOISONICOTINIC ACID2-Nitropyridine-4-carboxylic acid(2-AMINO-PYRIDIN-4-YL)-METHANOL2-AMINO-5-FLUORO-4-PICOLINE2-Aminoisonicotinic acid 2-Fluoroisonicotinic acid2-(2,2-DIMETHYL-PROPIONYLAMINO)-ISONICOTINIC ACID4-Pyridinecarbonyl chloride, 2-fluoro- (9CI)2-AMINO-3,5-DICHLORO-4-METHYLPYRIDINE2-ACETAMIDO-5-AMINO-4-PICOLINE2-ACETAMIDO-5-NITRO-4-PICOLINE2-HYDROXY-4-PYRIDINECARBOXALDEHYDE2-ACETAMIDO-4-METHYL-5-BROMOPYRIDINE2-Amino-5-nitro-4-picoline2-Acetylamino-4-methylpyridine2-Amino-5-bromo-4-methylpyridine
4-Methylpyridin-2-amineSupplier
Terma Medicare India Pvt Ltd Gold
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- 021-52530655 18930806002
- yuli@semsstar.com
Jinan Dexinjia Biological Technology Co., Ltd Gold
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- 0531-8237-5809 13210597381
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Jubilant Life Sciences(Shanghai)Ltd. Gold
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- 021-63907388-21 18017369769
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J & K SCIENTIFIC LTD.
- Tel
- 010-82848833 400-666-7788
- jkinfo@jkchemical.com
Meryer (Shanghai) Chemical Technology Co., Ltd.
- Tel
- 4006608290; 18621169109
- market03@meryer.com
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4-Methylpyridin-2-amine(695-34-1)Related Product Information
- 4-Methylpyridin-2-amine
- 2-Amino-3-nitro-4-picoline
- 6-METHYL-4-(TRIFLUOROMETHYL)PYRID-2-YL HYDRAZINE
- 2-Amino-4-(trifluoromethyl)pyridine
- 2-Amino-5-bromo-4-methyl-3-nitropyridine
- 2-Amino-4,6-dimethylpyridine
- 2-Amino-5-nitro-4-picoline
- 2,3-Diamino-5-methylpyridine
- 5-Amino-3-methylpyridine
- 3-AMINO-2-METHOXY-6-PICOLINE
- 5-METHYLPYRIDIN-3-AMINE
- 4-AMINO-2-METHYLPYRIDINE (4-AMINO-2-PICOLINE),2-METHYLPYRIDIN-4-AMINE,4-Amino-2-methylpyridine ,97%
- 2-METHYLPYRIDIN-3-AMINE,3-AMINO-2-METHYLPYRIDINE (3-AMINO-2-PICOLINE),3-Amino-2-methylpyridine ,97%
- 2,6-DICHLORO-4-METHYLPYRIDIN-3-AMINE
- 2-Amino-3-ethyl-6-methylpyridine
- 6-Amino-5-methylpyridine-3-carbonitrile ,97%,5-Cyano-2-amino-3-methylpyridine
- 5-IODO-6-METHYLPYRIDIN-2-AMINE
- 5-Amino-2-chloro-3-picoline