2-METHYL-4-HYDROXYMETHYLPYRIDINE
- Product Name
- 2-METHYL-4-HYDROXYMETHYLPYRIDINE
- CAS No.
- 105250-16-6
- Chemical Name
- 2-METHYL-4-HYDROXYMETHYLPYRIDINE
- Synonyms
- 2-Methyl-4-pyridinemethanol;(2-Methyl-4-pyridyl)methanol;4-Pyridinemethanol, 2-methyl-;(2-Methylpyridin-4-yl)methanol;(2-methyl-4-pyridinyl)methanol;(2-Methylpyridine-4-yl)methanol;2-METHYL-4-HYDROXYMETHYLPYRIDINE;4-Pyridinemethanol,2-methyl-(9CI);4-(Hydroxymethyl)-2-methylpyridine;2-METHYL-4-HYDROXYMETHYLPYRIDINE ISO 9001：2015 REACH
- CBNumber
- CB9363544
- Molecular Formula
- C7H9NO
- Formula Weight
- 123.15
- MOL File
- 105250-16-6.mol
2-METHYL-4-HYDROXYMETHYLPYRIDINE Property
- Boiling point:
- 131-140 °C(Press: 4 Torr)
- Density
- 1.092±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 13.46±0.10(Predicted)
- form
- powder
- color
- Pale yellow
Safety
- Hazard Codes
- Xn
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 26-36
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- L499730
- Product name
- 2-Methyl-4-hydroxymethylpyridine
- Purity
- Aldrich<sup>CPR</sup>
- Packaging
- 1 unit
- Price
- $113
- Updated
- 2025/07/31
- Product number
- L499730
- Product name
- 2-Methyl-4-hydroxymethylpyridine
- Purity
- Aldrich
- Packaging
- 250mg
- Price
- $110
- Updated
- 2024/03/01
- Product number
- M322180
- Product name
- (2-Methylpyridin-4-yl)methanol
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- M322180
- Product name
- (2-Methylpyridin-4-yl)methanol
- Packaging
- 500mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- 069912
- Product name
- 2-Methyl-4-hydroxymethylpyridine
- Purity
- 98%
- Packaging
- 1g
- Price
- $225
- Updated
- 2021/12/16
2-METHYL-4-HYDROXYMETHYLPYRIDINE Chemical Properties,Usage,Production
Synthesis Reference(s)
Synthesis, p. 483, 2002 DOI: 10.1055/s-2002-20960
Synthesis
152815-18-4
105250-16-6
General procedure for the synthesis of 2-methyl-4-hydroxymethylpyridine from (2-chloro-6-methylpyridin-4-yl)methanol: In a variant of the method described above, 2-chloro-6-methylpyridine-4-carboxylic acid, palladium catalyst (0.20 g, 10 mol% loaded on carbon), ethyl acetate (45 mL) and triethylamine (2.8 mL, 20 mmol) were mixed. The reaction mixture was placed under a hydrogen atmosphere at 1 atmosphere for 21 hours. Subsequently, additional Pearlman catalyst (0.2 g) was added and the reaction continued to be stirred for 5 hours under a hydrogen atmosphere to achieve dechlorination. Upon completion of the reaction, the mixture was filtered through a diatomaceous earth pad and the filtrate was concentrated. Purification by column chromatography (eluent ratio 5:95 methanol:dichloromethane) afforded (2-methylpyridin-4-yl)methanol (1.48 g, 88% yield). The obtained (2-methylpyridin-4-yl)methanol can be used to prepare 2-amino-3-(2-methylpyridin-4-yl)propionitrile, and 1-methyl-1H-indol-2-one carboxylic acid ((1S,2R)-2-{[cyano -(2-methylpyridin-4-ylmethyl)-methyl]-carbamoyl}-cyclohexyl)amide obtained by the method described above (186 mg, yield 62%). Results of mass spectrometry analysis: m/z 444 (M+H).
References
[1] Patent: US2004/77646, 2004, A1. Location in patent: Page 116
2-METHYL-4-HYDROXYMETHYLPYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-METHYL-4-HYDROXYMETHYLPYRIDINE manufacturers
- Product
- 2-METHYL-4-HYDROXYMETHYLPYRIDINE 105250-16-6
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-09-27