Description Biotechnological Production Uses
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4-Pyridoxic acid

Description Biotechnological Production Uses
Product Name
4-Pyridoxic acid
CAS No.
82-82-6
Chemical Name
4-Pyridoxic acid
Synonyms
4-Pyridoxic;Pyridoxic Acid;4-PYRIDOXIC ACID;4-pyridoxinicacid;4-pyridoxinsaeure;4-pyridoxylicacid;4-Pyridoxic acid >=98%;4-Pyridoxicacidcrystalline;4-pyridoxinecarboxylicacid;Chlorantraniliprole Impurity 7(Propyzamide)
CBNumber
CB6151957
Molecular Formula
C8H9NO4
Formula Weight
183.16
MOL File
82-82-6.mol
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4-Pyridoxic acid Property

Melting point:
258-261 °C (dec.) (lit.)
Boiling point:
584.5±50.0 °C(Predicted)
Density 
1.480±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Aqueous Base (Slightly), Water (Very Slightly)
pka
0.47±0.25(Predicted)
form 
Solid
color 
Pale Beige to Light Brown
Merck 
13,8071
Stability:
Hygroscopic
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
2
RTECS 
NS1800000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P9630
Product name
4-Pyridoxic acid
Purity
≥98%
Packaging
25mg
Price
$53.4
Updated
2024/03/01
Sigma-Aldrich
Product number
P9630
Product name
4-Pyridoxic acid
Purity
≥98%
Packaging
100mg
Price
$135
Updated
2024/03/01
TRC
Product number
P991875
Product name
4-Pyridoxic acid
Packaging
1g
Price
$605
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0026551
Product name
4-PYRIDOXIC ACID
Purity
95.00%
Packaging
100MG
Price
$649.31
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0026551
Product name
4-PYRIDOXIC ACID
Purity
95.00%
Packaging
500MG
Price
$902.9
Updated
2021/12/16
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4-Pyridoxic acid Chemical Properties,Usage,Production

Description

4-pyridoxic acid is a methylpyridine that is 2-methylpyridine substituted by a hydroxy group at C-3, a carboxy group at C-4, and a hydroxymethyl group at C-5. It is the catabolic product of vitamin B6 and is excreted in the urine. It has a role as a human metabolite and a mouse metabolite. It is a member of methylpyridines, a hydroxymethylpyridine, a monohydroxypyridine and a vitamin B6. It derives from an isonicotinic acid. It is a conjugate acid of a 4-pyridoxate.
https://pubchem.ncbi.nlm.nih.gov/compound/4-Pyridoxic-acid

Biotechnological Production

4-Pyridoxic acid is an inactive metabolite of pyridoxine.It is formed from pyridoxine via pyridoxal 5'-phosphate and pyridoxal intermediates by pyridoxine kinase or pyridoxamine phosphate oxidase, as well as pyridoxine-5'-phosphate oxidase, aldehyde dehydrogenase, or aldehyde oxidase.
4-Pyridoxic acid is the catabolic product of vitamin B6 (also known as pyridoxine, pyridoxal and pyradoxamine) which is excreted in the urine. Urinary levels of 4-pyridoxic acid are lower in females than in males and will be reduced in persons with riboflavin deficiency. 4-Pyridoxic acid is formed by the action of aldehyde oxidase I (an endogenous enzyme) and by microbial enzymes (pyridoxal 4-dehydrogenase), an NAD-dependent aldehyde dehydrogenase. 4-pyridoxic acid can be further broken down by the gut microflora via 4-pyridoxic acid dehydrogenase. This enzyme catalyzes the four electron oxidation of 4-pyridoxic acid to 3-hydroxy-2-methylpyridine-4,5-dicarboxylate, using nicotinamide adenine dinucleotide as a cofactor.

Uses

4-Pyridoxic acid is a catabolite of vitamin B6. It has been used as a standard in the clinical spectrometric analysis of metabolites.

Uses

4-Pyridoxic Acid, a catabolite of vitamin B6 (P991735), is a water-soluble B-group vitamin that can be used as a urinary diagnostic biomarker for determining the nutritional status of these vitamins.

Definition

ChEBI: 4-pyridoxic acid is a methylpyridine that is 2-methylpyridine substituted by a hydroxy group at C-3, a carboxy group at C-4, and a hydroxymethyl group at C-5. It is the catabolic product of vitamin B6 and is excreted in the urine. It has a role as a mouse metabolite and a human urinary metabolite. It is a member of methylpyridines, a hydroxymethylpyridine, a monohydroxypyridine and a vitamin B6. It is functionally related to an isonicotinic acid. It is a conjugate acid of a 4-pyridoxate.

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 4, p. 625, 1967 DOI: 10.1002/jhet.5570040427

Enzyme inhibitor

This oxidized derivative (FW = 171.15 g/mol) of pyridoxal is the chief catabolic product of pyridoxine, pyridoxal, and pyridoxamine degradation; it can be isolated from human urine. The carboxyl group has a pKa value of 5.50 while the phenolic OH has a value of 9.75. 4-Pyridoxic acid has a blue fluorescence which is maximal between pH 3 and 4. Heating 4-pyridoxic acid in 0.5 N acid will convert the metabolite to its lactone, which has an even stronger fluorescence. Target(s): dextransucrase; glucose dehydrogenase; pyridoxal dehydrogenase; and pyridoxaminephosphate oxidase.

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4-Pyridoxic acid Suppliers

Energy Chemical
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021-021-58432009 400-005-6266
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China
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BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
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Shanghai TaoSu Biochemical Technology Co., Ltd.
Tel
021-33632979
Fax
021-34692979
Email
info@tsbiochem.com
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China
ProdList
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Bide Pharmatech Ltd.
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400-1647117 15221909166
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+86-21-61629029
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product02@bidepharm.com
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China
ProdList
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ChemStrong Scientific Co.,Ltd
Tel
0755-66853366 15920483169
Fax
0755-28363542
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sales@chem-strong.com
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China
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Sichuan Wei Keqi Biological Technology Co., Ltd.
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028-81700200 18116577057
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Shanghai Macklin Biochemical Co.,Ltd.
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Shanghai Kewel Chemical Co., Ltd.
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Sigma-Aldrich
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DebyeTec.com Inc.
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