4-Pyridoxic acid
Description Biotechnological Production Uses- Product Name
- 4-Pyridoxic acid
- CAS No.
- 82-82-6
- Chemical Name
- 4-Pyridoxic acid
- Synonyms
- 4-Pyridoxic;Pyridoxic Acid;4-PYRIDOXIC ACID;4-pyridoxinicacid;4-pyridoxinsaeure;4-pyridoxylicacid;4-Pyridoxic acid >=98%;Vitamin B6 Impurity 49;4-Pyridoxic Acid in DMSO;Noradrenaline Impurity 17
- CBNumber
- CB6151957
- Molecular Formula
- C8H9NO4
- Formula Weight
- 183.16
- MOL File
- 82-82-6.mol
4-Pyridoxic acid Property
- Melting point:
- 258-261 °C (dec.) (lit.)
- Boiling point:
- 584.5±50.0 °C(Predicted)
- Density
- 1.480±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Aqueous Base (Slightly), Water (Very Slightly)
- pka
- 0.47±0.25(Predicted)
- form
- Solid
- color
- Pale Beige to Light Brown
- Merck
- 13,8071
- Stability:
- Hygroscopic
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- P9630
- Product name
- 4-Pyridoxic acid
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $51.75
- Updated
- 2025/07/31
- Product number
- P9630
- Product name
- 4-Pyridoxic acid
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $130.8
- Updated
- 2025/07/31
- Product number
- P991875
- Product name
- 4-Pyridoxic acid
- Packaging
- 1g
- Price
- $605
- Updated
- 2021/12/16
- Product number
- CHM0026551
- Product name
- 4-PYRIDOXIC ACID
- Purity
- 95.00%
- Packaging
- 100MG
- Price
- $649.31
- Updated
- 2021/12/16
- Product number
- CHM0026551
- Product name
- 4-PYRIDOXIC ACID
- Purity
- 95.00%
- Packaging
- 500MG
- Price
- $902.9
- Updated
- 2021/12/16
4-Pyridoxic acid Chemical Properties,Usage,Production
Description
4-pyridoxic acid is a methylpyridine that is 2-methylpyridine substituted by a hydroxy group at C-3, a carboxy group at C-4, and a hydroxymethyl group at C-5. It is the catabolic product of vitamin B6 and is excreted in the urine. It has a role as a human metabolite and a mouse metabolite. It is a member of methylpyridines, a hydroxymethylpyridine, a monohydroxypyridine and a vitamin B6. It derives from an isonicotinic acid. It is a conjugate acid of a 4-pyridoxate.
https://pubchem.ncbi.nlm.nih.gov/compound/4-Pyridoxic-acid
Biotechnological Production
4-Pyridoxic acid is an inactive metabolite of pyridoxine.It is formed from pyridoxine via pyridoxal 5'-phosphate and pyridoxal intermediates by pyridoxine kinase or pyridoxamine phosphate oxidase, as well as pyridoxine-5'-phosphate oxidase, aldehyde dehydrogenase, or aldehyde oxidase.
4-Pyridoxic acid is the catabolic product of vitamin B6 (also known as pyridoxine, pyridoxal and pyradoxamine) which is excreted in the urine. Urinary levels of 4-pyridoxic acid are lower in females than in males and will be reduced in persons with riboflavin deficiency. 4-Pyridoxic acid is formed by the action of aldehyde oxidase I (an endogenous enzyme) and by microbial enzymes (pyridoxal 4-dehydrogenase), an NAD-dependent aldehyde dehydrogenase. 4-pyridoxic acid can be further broken down by the gut microflora via 4-pyridoxic acid dehydrogenase. This enzyme catalyzes the four electron oxidation of 4-pyridoxic acid to 3-hydroxy-2-methylpyridine-4,5-dicarboxylate, using nicotinamide adenine dinucleotide as a cofactor.
Uses
4-Pyridoxic acid is a catabolite of vitamin B6. It has been used as a standard in the clinical spectrometric analysis of metabolites.
Uses
4-Pyridoxic Acid, a catabolite of vitamin B6 (P991735), is a water-soluble B-group vitamin that can be used as a urinary diagnostic biomarker for determining the nutritional status of these vitamins.
Definition
ChEBI: 4-pyridoxic acid is a methylpyridine that is 2-methylpyridine substituted by a hydroxy group at C-3, a carboxy group at C-4, and a hydroxymethyl group at C-5. It is the catabolic product of vitamin B6 and is excreted in the urine. It has a role as a mouse metabolite and a human urinary metabolite. It is a member of methylpyridines, a hydroxymethylpyridine, a monohydroxypyridine and a vitamin B6. It is functionally related to an isonicotinic acid. It is a conjugate acid of a 4-pyridoxate.
Synthesis Reference(s)
Journal of Heterocyclic Chemistry, 4, p. 625, 1967 DOI: 10.1002/jhet.5570040427
Enzyme inhibitor
This oxidized derivative (FW = 171.15 g/mol) of pyridoxal is the chief catabolic product of pyridoxine, pyridoxal, and pyridoxamine degradation; it can be isolated from human urine. The carboxyl group has a pKa value of 5.50 while the phenolic OH has a value of 9.75. 4-Pyridoxic acid has a blue fluorescence which is maximal between pH 3 and 4. Heating 4-pyridoxic acid in 0.5 N acid will convert the metabolite to its lactone, which has an even stronger fluorescence. Target(s): dextransucrase; glucose dehydrogenase; pyridoxal dehydrogenase; and pyridoxaminephosphate oxidase.
IC 50
Microbial Metabolite; Human Endogenous Metabolite
4-Pyridoxic acid Preparation Products And Raw materials
Raw materials
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View Lastest Price from 4-Pyridoxic acid manufacturers
- Product
- 4-Pyridoxic acid 82-82-6
- Price
- US $3.00-9.00/KG
- Min. Order
- 0.01KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2025-06-21
- Product
- Vitamin B6 Impurity 49 82-82-6
- Price
- US $0.00-0.00/mg
- Min. Order
- 10mg
- Purity
- 95
- Supply Ability
- 100000
- Release date
- 2025-02-12
- Product
- Vitamin B6 Impurity 49 82-82-6
- Price
- US $0.00-0.00/mg
- Min. Order
- 10mg
- Purity
- 98%
- Supply Ability
- 500mg
- Release date
- 2024-08-13