2-FORMYL-5-PICOLINE
- Product Name
- 2-FORMYL-5-PICOLINE
- CAS No.
- 4985-92-6
- Chemical Name
- 2-FORMYL-5-PICOLINE
- Synonyms
- 2-FORMYL-5-PICOLINE;5-Methylpicolinaldehyde;5-METHYL-2-PYRIDINALDEHYDE;5-Methylpyridine-2-carboxaldehyde;5-methyl-2-pyridinecarboxaldehyde;2-Pyridinecarboxaldehyde,5-Methyl-;5-Methylpyridine-2-carboxaldehydet;2-FORMYL-5-PICOLINE ISO 9001：2015 REACH
- CBNumber
- CB6432768
- Molecular Formula
- C7H7NO
- Formula Weight
- 121.14
- MOL File
- 4985-92-6.mol
2-FORMYL-5-PICOLINE Property
- Melting point:
- 41.5 °C
- Boiling point:
- 70-72 °C(Press: 0.7 Torr)
- Density
- 1.095±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- solid
- pka
- 4.01±0.10(Predicted)
- Appearance
- Off-white to light yellow <41.5°C Solid,>41.5°C Liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SYX00325
- Product name
- 5-Methylpyridine-2-carboxaldehyde
- Packaging
- 1g
- Price
- $179
- Updated
- 2025/07/31
- Product number
- M321390
- Product name
- 5-Methylpicolinaldehyde
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- Y14231
- Product name
- 5-Methylpyridine-2-carboxaldehyde
- Purity
- 98%
- Packaging
- 1g
- Price
- $20
- Updated
- 2021/12/16
- Product number
- W6532
- Product name
- 5-Methylpyridine-2-carbaldehyde
- Packaging
- 5g
- Price
- $101
- Updated
- 2021/12/16
- Product number
- 063862
- Product name
- 5-Methylpyridine-2-carbaldehyde
- Packaging
- 25g
- Price
- $259
- Updated
- 2021/12/16
2-FORMYL-5-PICOLINE Chemical Properties,Usage,Production
Synthesis
3510-66-5
68-12-2
4985-92-6
General procedure for the synthesis of 5-methylpyridine-2-aldehyde from 2-bromo-5-methylpyridine and N,N-dimethylformamide: 50 g (290 mmol) of 2-bromo-5-methylpyridine was dissolved in 2500 mL of diethyl ether and cooled to -78 °C. Subsequently, 150 mL (380 mmol) of n-butyllithium (nBuLi) was slowly added dropwise and the reaction mixture was stirred at -78 °C for 2 hours. Next, 31.5 mL (407 mmol) of N,N-dimethylformamide (DMF) was slowly added and the reaction mixture was allowed to gradually warm up to room temperature. Upon completion of the reaction, water was added to the mixture for quenching. The organic and aqueous layers were separated and the aqueous layer was extracted three times with ethyl acetate. All organic layers were combined, washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to remove the solvent to give a brown oil. The residue was purified by fast column chromatography (eluent: heptane/ethyl acetate, gradient 0 to 25% ethyl acetate) to give 19 g (39% yield) of brown solid product. Mass spectrum (APCI): m/z 122 ([M+H]+). 1H NMR (CDCl3, 360 MHz) δ (ppm): 2.48 (s, 3H, CH3); 7.70 (dd, J = 7.9, 2.0 Hz, 1H, pyridine H4); 7.91 (d, J = 7.7 Hz, 1H, pyridine H3); 8.68 (s, 1H, pyridine H6); 10.10 (s, 1H, aldehyde group).
References
[1] Angewandte Chemie - International Edition, 2018, vol. 57, # 8, p. 2238 - 2243
[2] Angew. Chem., 2018, vol. 130, # 8, p. 2260 - 2265,6
[3] Patent: WO2009/60030, 2009, A1. Location in patent: Page/Page column 38-39
[4] Chemistry - A European Journal, 2008, vol. 14, # 17, p. 5313 - 5328
[5] Bioorganic and Medicinal Chemistry, 2005, vol. 13, # 24, p. 6763 - 6770
2-FORMYL-5-PICOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-FORMYL-5-PICOLINE manufacturers
- Product
- 2-FORMYL-5-PICOLINE 4985-92-6
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-27
- Product
- 2-FORMYL-5-PICOLINE 4985-92-6
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 200kg
- Release date
- 2018-12-19