Pyridoxal 5'-phosphate monohydrate
Description Source Background- Product Name
- Pyridoxal 5'-phosphate monohydrate
- CAS No.
- 41468-25-1
- Chemical Name
- Pyridoxal 5'-phosphate monohydrate
- Synonyms
- PLP;PYRIDOXAL 5-PHOSPHATE MONOHYDRATE;5-Phosphate Monohydrate;PYRIDOXAL PHOSPHATE MONOHYDRATE;Pyridoxal 5-phosphate monohydrate(PLP);(4-ForMyl-5-hydroxy-6-Methylpyridin-3-yl)Methyl dihydrogen phosphate hydrate;Plp1;ACR1;B116;LIMT
- CBNumber
- CB6757175
- Molecular Formula
- C8H12NO7P
- Formula Weight
- 265.16
- MOL File
- 41468-25-1.mol
Pyridoxal 5'-phosphate monohydrate Property
- Melting point:
- 140-143 °C(lit.)
- storage temp.
- 2-8°C
- solubility
- Acetonitrile (Slightly), DMSO (Slightly)
- form
- Crystalline Powder
- color
- Pale yellow
- biological source
- synthetic
- Water Solubility
- 5 g/L (20 ºC)
- Sensitive
- Light Sensitive
- Merck
- 14,7979
- BRN
- 234749
- Stability:
- Air Sensitive, Moisture Sensitive
- InChI
- InChI=1S/C8H10NO6P.H2O/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14;/h2-3,11H,4H2,1H3,(H2,12,13,14);1H2
- InChIKey
- CEEQUQSGVRRXQI-UHFFFAOYSA-N
- SMILES
- C1(COP(=O)(O)O)=CN=C(C)C(O)=C1C=O.O
- CAS DataBase Reference
- 41468-25-1(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 24/25-36-26
- WGK Germany
- 2
- RTECS
- UV1208000
- F
- 8-10-23
- TSCA
- Yes
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 82870
- Product name
- Pyridoxal 5′-phosphate monohydrate
- Purity
- ≥97.0% (NT)
- Packaging
- 1g
- Price
- $76.2
- Updated
- 2025/07/31
- Product number
- 82870
- Product name
- Pyridoxal 5′-phosphate monohydrate
- Purity
- ≥97.0% (NT)
- Packaging
- 5g
- Price
- $265
- Updated
- 2025/07/31
- Product number
- SAB2501870
- Product name
- Anti-PDXP (C-terminal) antibody produced in goat
- Purity
- affinity isolated antibody, buffered aqueous solution
- Packaging
- 100μG
- Price
- $586
- Updated
- 2025/07/31
- Product number
- SRP6075
- Product name
- PRDX 5 human
- Purity
- recombinant, expressed in E. coli, ≥95% (SDS-PAGE)
- Packaging
- 100μG
- Price
- $483
- Updated
- 2023/06/20
- Product number
- C0377
- Product name
- Pyridoxal 5-Phosphate Monohydrate
- Purity
- >98.0%(HPLC)
- Packaging
- 1g
- Price
- $41
- Updated
- 2025/07/31
Pyridoxal 5'-phosphate monohydrate Chemical Properties,Usage,Production
Chemical Properties
Pyridoxal Phosphate Hydrate occurs as a pale yellow-white to light yellow crystalline powder.
It is slightly soluble in water, and practically insoluble in ethanol (99.5).
It dissolves in dilute hydrochloric acid and in sodium hydroxide TS.
The pH of a solution prepared by dissolving 0.1 g of Pyridoxal Phosphate Hydrate in 200 mL of water is between 3.0 and 3.5.
Pyridoxal Phosphate Hydrate is colored to light red by light.
Uses
Pyridoxal 5-phosphate (PLP) (active form of Vitamin B6) is an enzyme prosthetic group that acts as a coenzyme in transamination, decarboxylation and deamination reactions such as the conversion of dopa into dopamine; of glutamate into GABA; of histidine to histamine. PLP works mechanistically through formation of a Schiff-base.
Uses
Pyridoxal 5'-phosphate monohydrate is a water-soluble form of Pyridoxal 5′-phosphate (PLP), which can be used to synthesise the drug MC-1, a cardioprotective agent designed to reduce damage to the heart when arteries are blocked and subsequently reopened after bypass surgery. It is also widely used to cure the Parkinson's disease clinically.
Application
Pyridoxal 5′-phosphate (PLP), an active form of vitamin B6/ pyridoxine is the coenzyme of amino acid metabolism.
Pyridoxal 5′-phosphate monohydrate has been used:
as a component in the reaction mixture for ornithine decarboxylase (ODC) activity assay
as a standard to quantify the concentration of pyridoxal 5′-phosphate (PLP) in cerebrospinal fluid (CSF) of children
as a dietary supplement to study its effects on the lethal phenotype of mutant flies.
Definition
ChEBI: Pyridoxal 5-phosphate monohydrate is a pyridinecarbaldehyde.
Biosynthesis
Two distinct pathways for Pyridoxal 5′-phosphate (PLP) biosynthesis are known. 1.The 'DXP dependent' pathway is found in Escherichia coli and a few members of the γ subdivision of proteobacteria and has been extensively characterized. In this pathway deoxyxylulose 5-phosphate (DXP) is condensed with 3-hydroxy-1-aminoacetone phosphate to give PNP. PNP is oxidized to PLP by PdxH. The DXP dependent pathway is not widely distributed and is surprisingly complex requiring seven enzymes (GapB, PdxB, PdxF (SerC), PdxA, DXS, PdxJ and PdxH). This pathway was the first discovered and it has been extensively reviewed. 2. The second pathway uses Pdx1 and Pdx2 to catalyze the condensation of d-ribose 5-phosphate (R5P), glutamine and glyceraldehyde 3-phosphate to form PLP. The mechanistic and structural characterization of both pathways is at an advanced stage.
General Description
Pyridoxal 5'-phosphate (PLP, vitamin B6) is an essential cofactor in all living systems. It is one of the most versatile cofactors and participates in transamination, decarboxylation, racemization, Cα-Cβ cleavage and α-β elimination reactions. PLP plays an important role in amino acid and carbohydrate metabolism and has been implicated in singlet oxygen resistance. PLP can be used as a dietary supplement in cases of vitamin B6 deficiency. Reduced levels of PLP in the brain can cause neurological dysfunction. By inhibiting AGE formation and working as a coenzyme in chemical reactions, pyridoxal 5’-phosphate can support healthy nerve, eye, cardiovascular and kidney function.
Biological Activity
Pyridoxine participates in the production of lipid and neurotransmitters. Pyridoxal 5′-phosphate (PLP) serves as a cofactor to stabilize carbanions at Cα of amino acids. Pyridoxine deficiency results in peripheral neuropathy. Absence of PLP leads to neonatal epileptic encephalopathy. PLP acts as a coenzyme in transamination, decarboxylation and deamination reactions such as the conversion of dopa into dopamine; of glutamate into γ aminobutyric acid (GABA); of histidine to histamine. PLP works mechanistically through formation of a Schiff-base.
Solubility in water
The solubility of Pyridoxal 5'-phosphate monohydrate in binary mixed solvents of ethanol + water, isopropanol + water and acetone + water in the temperature range of 278.15K to 318.15K at normal atmospheric pressure increased with increasing temperature and molar fraction of water. It is exothermic in organic solvents and binary mixed solvents, where the mixing process is exothermic, whereas it is endothermic in water.
Description
PRDX5 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 162 amino acids (53-214 a.a.) and having a molecular mass of 17 kDa.
The PRDX5 is purified by proprietary chromatographic techniques.
Source
Escherichia Coli
Background
PRDX5 belongs to the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides with reducing equivalents supplied through the thioredoxin system. PRDX5 has an antioxidant protective function in different tissues under normal conditions and during inflammatory processes. Peroxiredoxin-5 interacts with peroxisome receptor 1 and is involved in intracellular redox signaling. PRDX5 is involved in intracellular redox signaling. Peroxiredoxin-5 is a significant antioxidant protein of lung epithelial cells for its expression in the human lung increases during inflammation. PRDX5 expression is upregulated in osteoarthritis. PRDX5 may be significant in mitochondrial genome stability. Peroxiredoxin-5 has a protective role in human tendon cells against oxidative stress by reducing apoptosis and upholding collagen synthesis.
Pyridoxal 5'-phosphate monohydrate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Pyridoxal 5'-phosphate monohydrate manufacturers
- Product
- Pyridoxal 5-phosphate Monohydrate(PLP) 41468-25-1
- Price
- US $1.00/KG
- Min. Order
- 10KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2025-10-14
- Product
- Pyridoxal 5'-phosphate monohydrate 41468-25-1
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 1000kg
- Release date
- 2025-08-22
- Product
- Pyridoxal 5-phosphate monohydrate(PLP) 41468-25-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- ≥98%(Excellent grade)
- Supply Ability
- 2tons
- Release date
- 2025-08-19