pyridoxal

Product Name: pyridoxal
CAS No.: 66-72-8
Chemical Name: pyridoxal
Synonyms: pyridoxal;PYRIDOXALE;PYRIDOXALDEHYDE;Pyridoxal Labeled d3;Metazachlor Impurity 8(Triflumizole);3-hydroxy-2-methyl-5-methylol-isonicotinaldehyde;3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde;3-Hydroxy-5-hydroxymethyl-2-methylpyridine-4-carbaldehyde;3-Hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarbaldehyde;3-(Hydroxymethyl)-5-hydroxy-6-methylpyridine-4-carbaldehyde
CBNumber: CB9917990
Molecular Formula: C8H9NO3
Formula Weight: 167.16
MOL File: 66-72-8.mol

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pyridoxal Property

Melting point:: 165 °C
Boiling point:: 412.8±40.0 °C(Predicted)
Density: 1.360±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: Solid
pka: pKa 4.20 (H2O t = 25 I = 0.1)(Approximate)
color: White to off-white
EPA Substance Registry System: 4-Pyridinecarboxaldehyde, 3-hydroxy-5-(hydroxymethyl)-2-methyl- (66-72-8)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: H955360
Product name: 3-hydroxy-5-(hydroxymethyl)-2-methylpyridine-4-carbaldehyde
Packaging: 5mg
Price: $45
Updated: 2021/12/16

TRC

Product number: H955360
Product name: 3-hydroxy-5-(hydroxymethyl)-2-methylpyridine-4-carbaldehyde
Packaging: 50mg
Price: $220
Updated: 2021/12/16

Activate Scientific

Product number: AS146640
Product name: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde
Purity: 95%
Packaging: 250mg
Price: $279
Updated: 2021/12/16

Activate Scientific

Product number: AS146640
Product name: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde
Purity: 95%
Packaging: 100mg
Price: $144
Updated: 2021/12/16

ChemScene

Product number: CS-0028583
Product name: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde
Packaging: 1g
Price: $489
Updated: 2021/12/16

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pyridoxal Chemical Properties,Usage,Production

Uses

Pyridoxal is a neuroprotectant. Pyridoxal is one of the main forms of vitamin B6. Pyridoxal is phosphorylated by pyridoxal kinase to pyridoxal phosphate (HY-B1744). Pyridoxal is oxidized by the liver to 4-pyridoxic acid (HY-113493) and excreted in the urine. Pyridoxal has shown promise in the study of carpal tunnel syndrome (CTS)[1][2][3].

Definition

ChEBI: A pyridinecarbaldehyde that is pyridine-5-carbaldehyde bearing methyl, hydroxy and hydroxymethyl substituents at positions 2, 3 and 4 respectively.

Enzyme inhibitor

This photosensitive aldehyde form of vitamin B6 (FW = 167.16 g/mol), systematically referred to as 3-hydroxy-5-(hydroxymethyl)-2-methyl-4- pyridinecarboxaldehyde, is the immediate precursor to the coenzyme pyridoxal 5’-phosphate (PLP) and is often a weaker competitive inhibitor of PLP binding to PLP-dependent enzymes). Pyridoxal is soluble in water (1 g/2 mL) and sensitive to heat, particularly at alkaline pH. The pKa values are 4.23 (phenol OH), 8.70 (pyridinium NH+), and 13.0. Pyridoxal has a lmax value of 252 nm at pH 7.0 (e = 8200 M–1cm–1). It is typically supplied as the hydrochloride. Target(s): O-acetylhomoserine aminocarboxypropyltransferase, or O-acetylhomoserine (thiol)-lyase; alanine racemase; aldehyde dehydrogenase; arginine decarboxylase; cystathionine b-lyase, or cystine lyase; cysteine synthase; dextransucrase; b-fructofuranosidase, or invertase; glutamate dehydrogenase; hemoglobin S polymerization; hydroxyacyl-glutathione hydrolase, or glyoxalase II; kynurenine 3- monooxygenase; lactoylglutathione lyase, or glyoxalase I; NMN nucleosidase; phosphopantothenoylcysteine decarboxylase; porphobilinogen synthase, or d-aminolevulinate dehydratase; pyridoxal kinase; pyridoxal phosphatase, weakly inhibited; starch phosphorylase; thiamin phosphatase; tyrosinase; and xanthine dehydrogenase.

IC 50

Human Endogenous Metabolite

References

[1] Vrolijk MF, et al. The vitamin B6 paradox: Supplementation with high concentrations of pyridoxine leads to decreased vitamin B6 function. Toxicol In Vitro. 2017 Oct;44:206-212. DOI:10.1016/j.tiv.2017.07.009
[2] Aufiero E, et al. Pyridoxine hydrochloride treatment of carpal tunnel syndrome: a review. Nutr Rev. 2004 Mar;62(3):96-104. DOI:10.1111/j.1753-4887.2004.tb00030.x
[3] Nagata, Yoshiko, Reiko Yoda, and Yoshikazu Matsushima. "Solvolysis of pyridoxal hydrochloride in alcohols." Chemical and pharmaceutical bulletin 41.6 (1993): 1019-1022.
[4] Vrolijk, Misha F., et al. "The vitamin B6 paradox: Supplementation with high concentrations of pyridoxine leads to decreased vitamin B6 function." Toxicology In Vitro 44 (2017): 206-212. DOI:10.1016/j.tiv.2017.07.009

pyridoxal Preparation Products And Raw materials

Raw materials

Preparation Products

Pyridoxal hydrochloride

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pyridoxal Suppliers

China 30 Finland 1 France 1 Germany 1 India 3 United Kingdom 2 United States 5 Global 43

China Langchem Inc.

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Shanghai Macklin Biochemical Co.,Ltd.

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Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

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Shenzhen SUNGENING Bio-Medical Co., Ltd.

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Alfa Chemistry

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Chemwill Asia Co.,Ltd.

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66-72-8, pyridoxal Related Search:

Cocarboxylase GSSG 3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridine-4-carbaldehyde, compound with 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxyisoquinoline (1:1) PPADS TETRASODIUM SALT PYRIDOXAL 5-PHOSPHATE, [14C] Pyridoxal 5'-phosphate monohydrate PYRIDOXAL-5'-PHOSPHATE-6-(2'-NAPHTHYLAZO-6'-NITRO-4',8'-DISULFONATE) TETRASODIUM SALT 6-fluoropyridoxal pyridoxal Pyridoxal hydrochloride PYRIDOXAL GALACTOSIDE 4-Pyridoxic acid MRS 2211

2-Methyl-3-hydroxy-5-(hydroxymethyl)pyridine-4-carbaldehyde

3-(Hydroxymethyl)-5-hydroxy-6-methylpyridine-4-carbaldehyde

3-Hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarbaldehyde

3-Hydroxy-5-hydroxymethyl-2-methylpyridine-4-carbaldehyde

3-hydroxy-2-methyl-5-methylol-isonicotinaldehyde

Pyridoxal Labeled d3

pyridoxal

PYRIDOXALDEHYDE

PYRIDOXALE

4-Pyridinecarboxaldehyde, 3-hydroxy-5-(hydroxymethyl)-2-methyl-

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde

Metazachlor Impurity 8(Triflumizole)

66-72-8