PPADS TETRASODIUM SALT

Product Name: PPADS TETRASODIUM SALT
CAS No.: 149017-66-3
Chemical Name: PPADS TETRASODIUM SALT
Synonyms: PPADS;C13745;PPADS tetrasodium sa;PPADS TETRASODIUM SALT;PPADS Tetrasodium Salt（149017-66-3）;PPADS, P2 purinergic receptor antagonist;pyridoxalphosphate-6-azophenyl-2’,4’-disulfonicacid;5'-phosphopyridoxal-6-azobenzene-2,4-disulfonic acid;PYRIDOXALPHOSPHATE-6-AZOPHENYL-2',4'-DISULPHONIC ACID 4NA;PYRIDOXAL-PHOSPHATE-6-AZOPHENYL-2',4'-DISULPHONIC ACID TETRASODIUM
CBNumber: CB9729515
Molecular Formula: C14H14N3O12PS2
Formula Weight: 511.38
MOL File: 149017-66-3.mol

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PPADS TETRASODIUM SALT Property

storage temp.: −20°C
solubility: H₂O: >10 mg/mL
form: solid
color: red to orange

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Safety

Safety Statements: 22-24/25
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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PPADS TETRASODIUM SALT Chemical Properties,Usage,Production

Uses

PPADS is a P2 receptor antagonist, with IC50s of 68 nM (P2X1) and 214 nM (P2X3). PPADS acts as an ATP (nucleotide) mimetic and competes with ATP for its binding site on P2 receptors. PPADS is also a reversible competitive antagonist of the NAADP receptor. PPADS reverses nociceptive hypersensitivity and reduces the increased NO/NOS system and IL-1β in both peripheral and central steps of nervous system[1][2][3].

Definition

ChEBI: An arenesulfonic acid that is pyridoxal 5'-phosphate carrying an additional 2,4-disulfophenylazo substituent at position 6.

Biological Activity

A non-selective P2 purinergic antagonist. Blocks recombinant P2X 1 , P2X 2 , P2X 3 , P2X 5 (IC 50 = 1 - 2.6 μ M), native P2Y 2 -like (IC 50 ~ 0.9 mM), and recombinant P2Y 4 (IC 50 ~ 15 mM) receptors.

IC 50

p2x1 Receptor: 68 nM (IC₅₀); P2X2 Receptor: 214 nM (IC₅₀)

References

[1] Billington RA, et al. PPADS is a reversible competitive antagonist of the NAADP receptor. Cell Calcium. 2007 Jun;41(6):505-11. DOI:10.1016/j.ceca.2006.10.002
[2] Brown SG, et al. Actions of a Series of PPADS Analogs at P2X1 and P2X3 Receptors. Drug Dev Res. 2001 Aug;53(4):281-291. DOI:10.1002/ddr.1197
[3] Martucci C, et al. The purinergic antagonist PPADS reduces pain related behaviours and interleukin-1 beta, interleukin-6, iNOS and nNOS overproduction in central and peripheral nervous system after peripheral neuropathy in mice. Pain. 2008 Jul;137(1):81-95. DOI:10.1016/j.pain.2007.08.017

PPADS TETRASODIUM SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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PPADS TETRASODIUM SALT Suppliers

China 34 Germany 3 United Kingdom 4 United States 3 Global 44

3B Pharmachem (Wuhan) International Co.,Ltd.

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TargetMol Chemicals Inc.

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149017-66-3, PPADS TETRASODIUM SALTRelated Search:

2-Amino-5-hydroxypyridine (2-Aminopyridin-3-yl)methanol 4-Amino-1,3-benzenedisulfonic acid 3-Hydroxypyridine-4-carboxaldehyde Sodium 2-amino-1,4-benzenedisulfonate 2-Amino-1,4-benzenedisulfonic acid Pyridoxal 5'-phosphate monohydrate 3-HYDROXY-5-METHYLPYRIDINE pyridoxal 3-HYDROXY-2,5-DIMETHYLPYRIDINE-4-CARBOXALDEHYDE Pyridoxal phosphate ISO-PPADS TETRASODIUM SALT PPADS TETRASODIUM SALT 4-deoxypyridoxine 6-AMINO-4-METHYLPYRIDIN-3-OL 3-HYDROXY-2-METHYLPYRIDINE-4-CARBOXALDEHYDE PPADS TETRASODIUM SALT 2-AMINOPYRIDINE-4-CARBALDEHYDE

4-[[4-FORMYL-5-HYDROXY-6-METHYL-3-[(PHOSPHONOOXY)METHYL]-2-PYRIDINYL]AZO]-1,3-BENZENEDISULFONIC ACID TETRASODIUM

PYRIDOXALPHOSPHATE-6-AZOPHENYL-2',4'-DISULFONIC ACID TETRASODIUM SALT

PYRIDOXALPHOSPHATE-6-AZOPHENYL-2',4'-DISULPHONIC ACID 4NA

PYRIDOXAL-PHOSPHATE-6-AZOPHENYL-2',4'-DISULPHONIC ACID TETRASODIUM

PPADS

PPADS TETRASODIUM SALT

pyridoxalphosphate-6-azophenyl-2’,4’-disulfonicacid

4-[[4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]-2-pyridinyl]azo]-1,3-benzenedisulfonic acid tetrasodium salt

pyridoxal phosphate-6-azo(benzene-2,4-disulfonic acid) tetrasodium salt

C13745

5'-phosphopyridoxal-6-azobenzene-2,4-disulfonic acid

1,3-Benzenedisulfonic acid, 4-[2-[4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]-2-pyridinyl]diazenyl]-

4-[(2E)-2-[4-formyl-6-methyl-5-oxo-3-(phosphonooxymethyl)pyridin-2-ylidene]hydrazinyl]benzene-1,3-disulfonicaci

PPADS tetrasodium sa

PPADS, P2 purinergic receptor antagonist

PPADS Tetrasodium Salt（149017-66-3）

149017-66-3

C14H10N3Na4O12PS

C14H14N3O12PS2

Purinergics

Purinergics P2 receptor