3-Hydroxypyridine-4-carboxaldehyde
Uses Application- Product Name
- 3-Hydroxypyridine-4-carboxaldehyde
- CAS No.
- 1849-54-3
- Chemical Name
- 3-Hydroxypyridine-4-carboxaldehyde
- Synonyms
- 4-FORMYL-3-HYDROXYPYRIDINE;3-HYDROXY-ISONICOTINALDEHYDE;3-Hydroxypyridin-4-carbaldehyde;3-HYDROXY-PYRIDINE-4-CARBALDEHYDE;3-HYDROXYPYRIDINE-4-CARBOXALDEHYDE;3-Hydroxy-4-pyridinecarboxaldehyde;4-Pyridinecarboxaldehyde, 3-hydroxy-;3-Hydroxypyridine-4-carboxaldehyde ISO 9001：2015 REACH;4-Formyl-3-hydroxypyridine 3-Hydroxy-isonicotinaldehyde
- CBNumber
- CB0108328
- Molecular Formula
- C6H5NO2
- Formula Weight
- 123.11
- MOL File
- 1849-54-3.mol
3-Hydroxypyridine-4-carboxaldehyde Property
- Melting point:
- 126-128 °C
- Boiling point:
- 323.8±22.0 °C(Predicted)
- Density
- 1.327±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- pka
- pK1:4.05(＋1);pK2:6.77(OH) (25°C)
- color
- Cream
- InChI
- InChI=1S/C6H5NO2/c8-4-5-1-2-7-3-6(5)9/h1-4,9H
- InChIKey
- NVLPDIRQWJSXLZ-UHFFFAOYSA-N
- SMILES
- C1=NC=CC(C=O)=C1O
- CAS DataBase Reference
- 1849-54-3
Safety
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39-24/25
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P233Keep container tightly closed.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304IF INHALED:
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P340Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362Take off contaminated clothing and wash before reuse.
P403Store in a well-ventilated place.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- H947165
- Product name
- 3-Hydroxypyridine-4-carboxaldehyde
- Packaging
- 1g
- Price
- $250
- Updated
- 2021/12/16
- Product number
- CS-W005203
- Product name
- 3-Hydroxypyridine-4-carboxaldehyde
- Purity
- >98.0%
- Packaging
- 1g
- Price
- $145
- Updated
- 2021/12/16
- Product number
- 072073
- Product name
- 3-Hydroxypyridine-4-carboxaldehyde
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $167
- Updated
- 2021/12/16
- Product number
- W3998
- Product name
- 3-Hydroxypyridine-4-carboxaldehyde
- Packaging
- 1g
- Price
- $231
- Updated
- 2021/12/16
- Product number
- 072073
- Product name
- 3-Hydroxypyridine-4-carboxaldehyde
- Purity
- 95+%
- Packaging
- 1g
- Price
- $333
- Updated
- 2021/12/16
3-Hydroxypyridine-4-carboxaldehyde Chemical Properties,Usage,Production
Uses
3-Hydroxypyridine-4-aldehyde is an aldehyde organic compound, mainly used as a pharmaceutical intermediate.
Application
In basic organic chemistry research, 3-hydroxypyridine-4-aldehyde can be used as a synthetic raw material for organic ligands for the structural modification and synthesis of pyridine ligands. By modifying the compound with different functional groups, its electronic properties, stereochemical properties, etc. can be changed, thus modulating the properties of the synthesized organic ligands. In addition, 3-hydroxypyridine-4-aldehyde can be used as a pyridine-like substrate for evaluating the applicability of newly developed synthetic methods and optimization of reaction conditions.
Synthesis
666234-13-5
1849-54-3
To a stirred solution of 3-methoxymethoxypyridine-4-carboxaldehyde (11.0 g, 65.83 mmol) in tetrahydrofuran (THF, 50 mL) was added 3 N hydrochloric acid (HCl, 100 mL) and the reaction mixture was stirred for 1 h at 60 °C. The reaction was carried out in an ice bath. Upon completion of the reaction, the mixture was cooled in an ice bath and the pH was adjusted with solid potassium carbonate (K2CO3) to 7. Subsequently, the mixture was extracted with ethyl acetate (EtOAc, 5 × 250 mL). The organic layers were combined, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography (100-200 mesh) with 23% ethyl acetate/hexane as eluent to give 3-hydroxypyridine-4-carboxaldehyde (4.0 g, 32.496 mmol, 49.4% yield) as a light yellow solid. The product was analyzed by GC-MS showing a molecular ion peak of 123 (m/z), and the 1H-NMR (DMSO-d6, 400 MHz) data were as follows: δ 11.04 (broad single peak, 1H), 10.37 (single peak, 1H), 8.46 (single peak, 1H), 8.20 (double peak, 1H, J = 4.88 Hz), and 7.46 (double peak, 1H, J = 4.88 Hz).The purity of GC-FID analysis was 99.51%.
References
[1] Patent: WO2016/27241, 2016, A1. Location in patent: Page/Page column 30; 43
[2] Patent: WO2014/186035, 2014, A1. Location in patent: Page/Page column 146
3-Hydroxypyridine-4-carboxaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Hydroxypyridine-4-carboxaldehyde manufacturers
- Product
- 3-Hydroxypyridine-4-carboxaldehyde 1849-54-3
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-09-26
- Product
- 3-Hydroxypyridine-4-carboxaldehyde 1849-54-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%
- Supply Ability
- 500KG
- Release date
- 2018-08-19