PPADS TETRASODIUM SALT

Product Name: PPADS TETRASODIUM SALT
CAS No.: 149017-66-3
Chemical Name: PPADS TETRASODIUM SALT
Synonyms: PPADS;C13745;PPADS tetrasodium sa;PPADS TETRASODIUM SALT;PPADS Tetrasodium Salt（149017-66-3）;PPADS, P2 purinergic receptor antagonist;pyridoxalphosphate-6-azophenyl-2’,4’-disulfonicacid;5'-phosphopyridoxal-6-azobenzene-2,4-disulfonic acid;PYRIDOXALPHOSPHATE-6-AZOPHENYL-2',4'-DISULPHONIC ACID 4NA;PYRIDOXAL-PHOSPHATE-6-AZOPHENYL-2',4'-DISULPHONIC ACID TETRASODIUM
CBNumber: CB9729515
Molecular Formula: C14H14N3O12PS2
Formula Weight: 511.38
MOL File: 149017-66-3.mol

More

Less

PPADS TETRASODIUM SALT Property

storage temp.: −20°C
solubility: H₂O: >10 mg/mL
form: solid
color: red to orange

More

Less

Safety

Safety Statements: 22-24/25
WGK Germany: 3

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

PPADS TETRASODIUM SALT Chemical Properties,Usage,Production

Uses

PPADS is a P2 receptor antagonist, with IC50s of 68 nM (P2X1) and 214 nM (P2X3). PPADS acts as an ATP (nucleotide) mimetic and competes with ATP for its binding site on P2 receptors. PPADS is also a reversible competitive antagonist of the NAADP receptor. PPADS reverses nociceptive hypersensitivity and reduces the increased NO/NOS system and IL-1β in both peripheral and central steps of nervous system[1][2][3].

Definition

ChEBI: An arenesulfonic acid that is pyridoxal 5'-phosphate carrying an additional 2,4-disulfophenylazo substituent at position 6.

Biological Activity

A non-selective P2 purinergic antagonist. Blocks recombinant P2X 1 , P2X 2 , P2X 3 , P2X 5 (IC 50 = 1 - 2.6 μ M), native P2Y 2 -like (IC 50 ~ 0.9 mM), and recombinant P2Y 4 (IC 50 ~ 15 mM) receptors.

IC 50

p2x1 Receptor: 68 nM (IC₅₀); P2X2 Receptor: 214 nM (IC₅₀)

References

[1] Billington RA, et al. PPADS is a reversible competitive antagonist of the NAADP receptor. Cell Calcium. 2007 Jun;41(6):505-11. DOI:10.1016/j.ceca.2006.10.002
[2] Brown SG, et al. Actions of a Series of PPADS Analogs at P2X1 and P2X3 Receptors. Drug Dev Res. 2001 Aug;53(4):281-291. DOI:10.1002/ddr.1197
[3] Martucci C, et al. The purinergic antagonist PPADS reduces pain related behaviours and interleukin-1 beta, interleukin-6, iNOS and nNOS overproduction in central and peripheral nervous system after peripheral neuropathy in mice. Pain. 2008 Jul;137(1):81-95. DOI:10.1016/j.pain.2007.08.017

PPADS TETRASODIUM SALT Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

PPADS TETRASODIUM SALT Suppliers

China 34 Germany 3 United Kingdom 4 United States 3 Global 44

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Jinan Yaoyan Pharmaceutical Co., Ltd.

Tel
Fax: -
Email: jnyaoyan@163.com
Country: China
ProdList: 3069
Advantage: 58

Nanjing Meihao Pharmaceutical Technology Co., Ltd.

Tel: meitaochem@126.com
Email: meitaochem@126.com
Country: China
ProdList: 19103
Advantage: 58

Abmole Bioscience Inc.

Tel: 021-50967598 02150967598
Email: sales@abmole.cn
Country: China
ProdList: 4494
Advantage: 58

JinOu Biomedical (Nanjing) Co., Ltd.

Tel: 13000000000
Fax: jinoupharma@163
Email: jinoupharma@163.com
Country: China
ProdList: 11721
Advantage: 58

Shanghai Universal Biotech Co.,Ltd

Tel: 15921930842 15921930842
Email: yh-wang@univ-bio.com
Country: China
ProdList: 25004
Advantage: 58

Shanghai Aladdin Biochemical Technology Co.,Ltd.

Tel: 400-6206333 13167063860
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 48457
Advantage: 58

TargetMol Chemicals Inc.

Tel: 15002134094
Email: marketing@targetmol.cn
Country: China
ProdList: 29423
Advantage: 58

Wuhan Topule Biopharmaceutical Co., Ltd

Tel: +8618327326525
Email: masar@topule.com
Country: China
ProdList: 8467
Advantage: 58

Hangzhou Haofeng Biotechnology Co., Ltd.

Tel: 057186405477
Country: CHINA
ProdList: 184
Advantage: 58

Guangzhou Squirrel Biotechnology Co., Ltd.

Tel: 17765276361
Country: CHINA
ProdList: 109
Advantage: 58

Guangzhou Weisheng Biotechnology Co., Ltd.

Tel: 17765667235
Country: CHINA
ProdList: 129
Advantage: 58

Boppard-China

Tel: --
Fax: --
Email: info@boppard.cn
Country: China
ProdList: 687
Advantage: 58

Wuhan Kehaojia Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 2248475041@qq.com
Country: CHINA
ProdList: 3048
Advantage: 58

Beijing Xiangsheng Xingye Technology Co., Ltd.

Tel: --
Fax: --
Email: xs_bio@163.com
Country: CHINA
ProdList: 5130
Advantage: 58

Beijing Huaxia Ocean Technology Co., Ltd.

Tel: --
Fax: --
Email: huaxiabio@163.com
Country: CHINA
ProdList: 6122
Advantage: 58

Beijing Fubo Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: info@f-biology.com
Country: CHINA
ProdList: 6170
Advantage: 58

Beijing Baiao Innovation Technology Co., Ltd.

Tel: --
Fax: --
Email: 3007606172@qq.com
Country: CHINA
ProdList: 6002
Advantage: 58

Shanghai Yupu Chemical Technology Co., Ltd.

Tel: --
Fax: --
Email: 2439781853@qq.com
Country: CHINA
ProdList: 1328
Advantage: 58

Shanghai Weiwei Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: sales@wheybio.com
Country: CHINA
ProdList: 4398
Advantage: 58

Beijing Bolide Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 1985563437@qq.com
Country: CHINA
ProdList: 6525
Advantage: 58

Beijing Bai Ao Si Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: yangmei@bioneeds.net
Country: CHINA
ProdList: 6999
Advantage: 58

Shanghai Haoyang Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: 596799915@QQ.COM
Country: CHINA
ProdList: 2905
Advantage: 58

Guangzhou Weijia Technology Co., Ltd.

Tel: --
Fax: --
Email: WHIGA22@126.COM
Country: CHINA
ProdList: 6757
Advantage: 58

Beijing Taize Ruida Technology Co., Ltd.

Tel: --
Fax: --
Email: taizeorder@163.com
Country: CHINA
ProdList: 6536
Advantage: 58

Shanghai Chaoyan Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 471161314@qq.com
Country: CHINA
ProdList: 6210
Advantage: 58

Qingdao Jieshikang Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: jskangchina@163.com
Country: CHINA
ProdList: 4980
Advantage: 58

Beijing Sizhengbai Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: marketing@4abio.com
Country: CHINA
ProdList: 6401
Advantage: 58

Fujifilm Wako (Guangzhou) Trading Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 1409
Advantage: 58

Dongguan Biaobiao Experimental Equipment Technology Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6672
Advantage: 58

Beijing Dongge Boye Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 1861586486@qq.com
Country: CHINA
ProdList: 6648
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6650
Advantage: 58

Guangzhou WeiBo Chemical Co., Ltd.

Tel: --
Fax: --
Email: weibochem@163.com
Country: China
ProdList: 6187
Advantage: 67

149017-66-3, PPADS TETRASODIUM SALTRelated Search:

2-Amino-5-hydroxypyridine (2-Aminopyridin-3-yl)methanol 4-Amino-1,3-benzenedisulfonic acid 3-Hydroxypyridine-4-carboxaldehyde Sodium 2-amino-1,4-benzenedisulfonate 2-Amino-1,4-benzenedisulfonic acid Pyridoxal 5'-phosphate monohydrate 3-HYDROXY-5-METHYLPYRIDINE pyridoxal 3-HYDROXY-2,5-DIMETHYLPYRIDINE-4-CARBOXALDEHYDE Pyridoxal phosphate ISO-PPADS TETRASODIUM SALT PPADS TETRASODIUM SALT 4-deoxypyridoxine 6-AMINO-4-METHYLPYRIDIN-3-OL 3-HYDROXY-2-METHYLPYRIDINE-4-CARBOXALDEHYDE PPADS TETRASODIUM SALT 2-AMINOPYRIDINE-4-CARBALDEHYDE

4-[[4-FORMYL-5-HYDROXY-6-METHYL-3-[(PHOSPHONOOXY)METHYL]-2-PYRIDINYL]AZO]-1,3-BENZENEDISULFONIC ACID TETRASODIUM

PYRIDOXALPHOSPHATE-6-AZOPHENYL-2',4'-DISULFONIC ACID TETRASODIUM SALT

PYRIDOXALPHOSPHATE-6-AZOPHENYL-2',4'-DISULPHONIC ACID 4NA

PYRIDOXAL-PHOSPHATE-6-AZOPHENYL-2',4'-DISULPHONIC ACID TETRASODIUM

PPADS

PPADS TETRASODIUM SALT

pyridoxalphosphate-6-azophenyl-2’,4’-disulfonicacid

4-[[4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]-2-pyridinyl]azo]-1,3-benzenedisulfonic acid tetrasodium salt

pyridoxal phosphate-6-azo(benzene-2,4-disulfonic acid) tetrasodium salt

C13745

5'-phosphopyridoxal-6-azobenzene-2,4-disulfonic acid

1,3-Benzenedisulfonic acid, 4-[2-[4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]-2-pyridinyl]diazenyl]-

4-[(2E)-2-[4-formyl-6-methyl-5-oxo-3-(phosphonooxymethyl)pyridin-2-ylidene]hydrazinyl]benzene-1,3-disulfonicaci

PPADS tetrasodium sa

PPADS, P2 purinergic receptor antagonist

PPADS Tetrasodium Salt（149017-66-3）

149017-66-3

C14H10N3Na4O12PS

C14H14N3O12PS2

Purinergics

Purinergics P2 receptor