Pyridoxal 5'-phosphate monohydrate

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Pyridoxal 5'-phosphate monohydrate

Product Name: Pyridoxal 5'-phosphate monohydrate
CAS No.: 41468-25-1
Chemical Name: Pyridoxal 5'-phosphate monohydrate
Synonyms: PLP;PYRIDOXAL 5-PHOSPHATE MONOHYDRATE;5-Phosphate Monohydrate;PYRIDOXAL PHOSPHATE MONOHYDRATE;Pyridoxal 5-phosphate monohydrate(PLP);(4-ForMyl-5-hydroxy-6-Methylpyridin-3-yl)Methyl dihydrogen phosphate hydrate;Plp1;ACR1;B116;AOEB116
CBNumber: CB6757175
Molecular Formula: C8H12NO7P
Formula Weight: 265.16
MOL File: 41468-25-1.mol

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Pyridoxal 5'-phosphate monohydrate Property

Melting point:: 140-143 °C(lit.)
storage temp.: 2-8°C
solubility: Acetonitrile (Slightly), DMSO (Slightly)
form: Crystalline Powder
color: Pale yellow
Water Solubility: 5 g/L (20 ºC)
Sensitive: Light Sensitive
Merck: 14,7979
BRN: 234749
Stability:: Air Sensitive, Moisture Sensitive
InChI: InChI=1S/C8H10NO6P.H2O/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14;/h2-3,11H,4H2,1H3,(H2,12,13,14);1H2
InChIKey: CEEQUQSGVRRXQI-UHFFFAOYSA-N
SMILES: C1(COP(=O)(O)O)=CN=C(C)C(O)=C1C=O.O
CAS DataBase Reference: 41468-25-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 24/25-36-26
WGK Germany: 2
RTECS: UV1208000
F: 8-10-23
TSCA: Yes
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 82870
Product name: Pyridoxal 5′-phosphate monohydrate
Purity: ≥97.0% (NT)
Packaging: 1g
Price: $71.3
Updated: 2024/03/01

Sigma-Aldrich

Product number: 82870
Product name: Pyridoxal 5′-phosphate monohydrate
Purity: ≥97.0% (NT)
Packaging: 5g
Price: $248
Updated: 2024/03/01

Sigma-Aldrich

Product number: SAB2501870
Product name: Anti-PDXP (C-terminal) antibody produced in goat
Purity: affinity isolated antibody, buffered aqueous solution
Packaging: 100μG
Price: $568
Updated: 2024/03/01

Sigma-Aldrich

Product number: SRP6075
Product name: PRDX 5 human
Purity: recombinant, expressed in E. coli, ≥95% (SDS-PAGE)
Packaging: 100μG
Price: $483
Updated: 2023/06/20

TCI Chemical

Product number: C0377
Product name: Pyridoxal 5-Phosphate Monohydrate
Purity: >98.0%(HPLC)
Packaging: 1g
Price: $43
Updated: 2024/03/01

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Pyridoxal 5'-phosphate monohydrate Chemical Properties,Usage,Production

Chemical Properties

Pyridoxal Phosphate Hydrate occurs as a pale yellow-white to light yellow crystalline powder.
It is slightly soluble in water, and practically insoluble in ethanol (99.5).
It dissolves in dilute hydrochloric acid and in sodium hydroxide TS.
The pH of a solution prepared by dissolving 0.1 g of Pyridoxal Phosphate Hydrate in 200 mL of water is between 3.0 and 3.5.
Pyridoxal Phosphate Hydrate is colored to light red by light.

Uses

Pyridoxal 5-phosphate (PLP) (active form of Vitamin B6) is an enzyme prosthetic group that acts as a coenzyme in transamination, decarboxylation and deamination reactions such as the conversion of dopa into dopamine; of glutamate into GABA; of histidine to histamine. PLP works mechanistically through formation of a Schiff-base.

Application

Pyridoxal 5′-phosphate (PLP), an active form of vitamin B6/ pyridoxine is the coenzyme of amino acid metabolism.
Pyridoxal 5′-phosphate monohydrate has been used:
as a component in the reaction mixture for ornithine decarboxylase (ODC) activity assay
as a standard to quantify the concentration of pyridoxal 5′-phosphate (PLP) in cerebrospinal fluid (CSF) of children
as a dietary supplement to study its effects on the lethal phenotype of mutant flies.

Definition

ChEBI: Pyridoxal 5-phosphate monohydrate is a pyridinecarbaldehyde.

Biosynthesis

Two distinct pathways for Pyridoxal 5′-phosphate (PLP) biosynthesis are known. 1.The 'DXP dependent' pathway is found in Escherichia coli and a few members of the γ subdivision of proteobacteria and has been extensively characterized. In this pathway deoxyxylulose 5-phosphate (DXP) is condensed with 3-hydroxy-1-aminoacetone phosphate to give PNP. PNP is oxidized to PLP by PdxH. The DXP dependent pathway is not widely distributed and is surprisingly complex requiring seven enzymes (GapB, PdxB, PdxF (SerC), PdxA, DXS, PdxJ and PdxH). This pathway was the first discovered and it has been extensively reviewed. 2. The second pathway uses Pdx1 and Pdx2 to catalyze the condensation of d-ribose 5-phosphate (R5P), glutamine and glyceraldehyde 3-phosphate to form PLP. The mechanistic and structural characterization of both pathways is at an advanced stage.

General Description

Pyridoxal 5'-phosphate (PLP, vitamin B6) is an essential cofactor in all living systems. It is one of the most versatile cofactors and participates in transamination, decarboxylation, racemization, Cα-Cβ cleavage and α-β elimination reactions. PLP plays an important role in amino acid and carbohydrate metabolism and has been implicated in singlet oxygen resistance. PLP can be used as a dietary supplement in cases of vitamin B6 deficiency. Reduced levels of PLP in the brain can cause neurological dysfunction. By inhibiting AGE formation and working as a coenzyme in chemical reactions, pyridoxal 5’-phosphate can support healthy nerve, eye, cardiovascular and kidney function.

Biological Activity

Pyridoxine participates in the production of lipid and neurotransmitters. Pyridoxal 5′-phosphate (PLP) serves as a cofactor to stabilize carbanions at Cα of amino acids. Pyridoxine deficiency results in peripheral neuropathy. Absence of PLP leads to neonatal epileptic encephalopathy. PLP acts as a coenzyme in transamination, decarboxylation and deamination reactions such as the conversion of dopa into dopamine; of glutamate into γ aminobutyric acid (GABA); of histidine to histamine. PLP works mechanistically through formation of a Schiff-base.

Pyridoxal 5'-phosphate monohydrate Preparation Products And Raw materials

Raw materials

Preparation Products

DL-Tryptophan

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View Lastest Price from Pyridoxal 5'-phosphate monohydrate manufacturers

Baoji Guokang Bio-Technology Co., Ltd.

Product: Pyridoxal 5'-phosphate monohydrate 41468-25-1
Price: US $318.00/Kg/Bag
Min. Order: 1KG
Purity: 98%
Supply Ability: 1T
Release date: 2021-06-04

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Pyridoxal 5'-phosphate monohydrate 41468-25-1
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.0%~102.0%
Supply Ability: 1000kg/month
Release date: 2021-06-23

airuikechemical co., ltd.

Product: pyridoxal 5′-phosphate 41468-25-1
Price: US $0.00-0.00/Kg
Min. Order: 1Kg
Purity: 99.9%
Supply Ability: 200tons
Release date: 2024-04-08

41468-25-1, Pyridoxal 5'-phosphate monohydrateRelated Search:

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