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Pyridoxal 5’-Phosphate

Product Name
Pyridoxal 5’-Phosphate
CAS No.
853645-22-4
Chemical Name
Pyridoxal 5’-Phosphate
Synonyms
Pyridoxal 5’3-Hydroxy-2-methyl-5;-phosphate (hydrate);PYRIDOXAL-5-PHOSPHATE;PYRIDOXAL-5'-PHOSPHATE;Pyridoxaol-5-phosphate;Pyridoxal-[d3] Phosphate;PYRIDOXAL 5'-PHOSPHATE HYDRATE, >=98;PYRIDOXAL 5'-PHOSPHATE HYDRATE POWDE;Pyridoxal-[d3] Phosphate(Vitamin B6-[d3])
CBNumber
CB22131140
Molecular Formula
C8H10NO6P
Formula Weight
247.14
MOL File
853645-22-4.mol
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Pyridoxal 5’-Phosphate Property

Melting point:
140-143 ºC
storage temp. 
?20°C
pka
pKa 8.69(H2O t = 25 I = 0.15)(Approximate)
form 
powder
BRN 
234749
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P9255
Product name
Pyridoxal 5′-phosphate hydrate
Purity
≥98%
Packaging
1g
Price
$64
Updated
2020/08/18
Sigma-Aldrich
Product number
P3657
Product name
Pyridoxal 5′-phosphate hydrate
Purity
powder, BioReagent, suitable for cell culture
Packaging
1g
Price
$64
Updated
2020/08/18
Cayman Chemical
Product number
20352
Product name
Pyridoxal 5'-phosphate (hydrate)
Purity
≥95%
Packaging
5g
Price
$123
Updated
2021/03/22
Cayman Chemical
Product number
20352
Product name
Pyridoxal 5'-phosphate (hydrate)
Purity
≥95%
Packaging
1g
Price
$35
Updated
2021/03/22
Sigma-Aldrich
Product number
P9255
Product name
Pyridoxal 5′-phosphate hydrate
Purity
≥98%
Packaging
25g
Price
$556
Updated
2020/08/18
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Pyridoxal 5’-Phosphate Chemical Properties,Usage,Production

Uses

Enzyme cofactor.Normal coenzyme form of Vitamin B6

Enzyme inhibitor

This vitamin B6-derived coenzyme (FWfree-acid = 247.14 g/mol; CAS 853645-22-4), often abbreviated PLP, plays a central role in metabolism. In addition to facilitating aminotransfer reactions, PLP is a coenzyme in reactions involving: (a) loss of the a-proton, resulting in racemization, cyclization, or b-elimination/replacement (e.g., alanine racemase, 1- aminocyclopropane-1-carboxylate synthase, and serine dehydratase, respectively); (b) loss of the a-carboxylate as carbon dioxide (e.g., glutamate decarboxylase); (c) removal/replacement of a group by aldol cleavage (e.g., threonine aldolase); and (d) catalysis via ketimine intermediates (e.g., selenocysteine lyase). PLP is also often employed as an inhibitor and site-directed, conformationally sensitive reporter group for studying the environment of reactive amino groups within proteins. PLP forms aldimine adducts that can be reduced with nucleophilic reducing reagents such as sodium borohydride or sodium cyanoborohydride. Solid PLP is light-sensitive, and solutions should be prepared fresh. There are four pKa values associated with this coenzyme: a pKa < 2.5 and another at 6.20 for the phosphate group, a pKa of 4.14 for the hydroxyl group, and a pKa of 8.69 for the pyridinium group. The coenzyme has an ultraviolet/visible spectrum: lmax = 330 nm and 388 nm (e = 2500 and 4900 M–1cm–1, respectively) in 50 mM phosphate buffer at pH 7.0; lmax = 305 nm and 388 nm (e = 1100 and 6550 M–1cm–1, respectively) in 100 mM NaOH. Pyridoxal 5’-phosphate may also be used as a photosensitizing agent to modify nearby aminoacyl residues (e.g., histidyl residues in 6- phosphogluconate dehydrogenase and tryptophanase). Target(s): acetylcholinesterase; acetyl-CoA carboxylase; acetyl-CoA synthetase, or acetate:CoA ligase; N-acetylneuraminate 4-Oacetyltransferase; acyl-[acyl-carrier-protein]:UDP-Nacetylglucosamine O-acyltransferase, followed by NaBH4 reduction; acylphosphatase; adenylate cyclase; [b-adrenergic-receptor] kinase; alanine racemase; alcohol dehydrogenase, followed by NaBH4 reduction; alcohol sulfotransferase (170; aldose reductase; allantoate deiminase; N-(5-amino-5-carboxypentanoyl)-Lcysteinyl- D-valine synthetase; 5-aminoleulinate synthase, in the presence of borohydride; aryl-acylamidase; aspartate carbamoyltransferase; aspartyl aminopeptidase; ATPdependent deoxyribonuclease; BglI restriction endonuclease, type II site-specific deoxyribonuclease; biliverdin reductase; carbonic anhydrase, or carbonate dehydratase; casein kinase II; catechol O-methyltransferase; cathepsin B; cathepsin K; cathepsin L; cathepsin S; Ca2+-transporting ATPase; cerebroside sulfotransferase; cholesterol monooxygenase, side-chain cleaving, or cytochrome P450scc; zcrystallin/ NADPH:quinone oxidoreductase; cytosine deaminase; dextransucrase; dipeptidyl-peptidase I, or cathepsin C; DNA-directed DNA polymerase; f29 DNA polymerase; DNA topoisomerase I; DNA topoisomerase II; dopa decarboxylase; estrone sulfotransferase; exodeoxyribonuclease V; F1 ATPase, or H+-transporting two-sector ATPase; fatty-acid synthase, at enoyl-[acyl-carrier protein] reductase; fatty-acyl-CoA synthase, yeast, at 3-ketoacyl-[acyl-carrier protein] reductase step; flavin-containing monooxygenase; bfructofuranosidase, or invertase; fructose-1,6-bisphosphate aldolase; fructose-6-phosphate 2-kinase/fructose-2,6- bisphosphatase; a1?3 fucosyltransferase; galactosylceramide sulfotransferase; glucan 1,4-a-glucosidase, or glucoamylase, weakly inhibited; glucose-6-phosphatase; glucose-1-phosphate adenylyltransferase; glucose-6-phosphate dehydrogenase; aglucosidase; glucuronate reductase; glutamate decarboxylase; glutamate dehydrogenase; glutathione-disulfide reductase; glutathione synthetase, slowly inhibited; glyceraldehyde-3- phosphate dehydrogenase; glycerol-1,2-cyclic-phosphate phosphodiesterase; glycerol dehydrogenase; glycogen phosphorylase; glycolipid sulfotransferase; glycoprotein Nacetylglucosaminyltransferase; glycoprotein 6-a-L-fucosyltransferase; glycoprotein galactosyltransferase; glycoprotein sialyltransferase; hemoglobin S polymerization; hexokinase; HIV (human immunodeficiency virus) reverse transcriptase; H+/K+- exchanging ATPase; homoserine kinase; H+-transporting ATPase, chloroplast; 2’-hydroxybiphenyl-2-sulfinate desulfinase; w-hydroxy-fatty-acid:NADP+ oxidoreductase; hydroxyindole-Omethyltransferase (acetylserotonin O-methyltransferase; hydroxymethylbilane synthase; 4-hydroxyphenylpyruvate dioxygenase; inositol-phosphate phosphatase; inositol-3- phosphate synthase, or inositol-1-phosphate synthase; integrase, HIV; a-ketoglutarate carrier; a-ketoglutarate dehydrogenase; kynurenine 3-monooxygenase; lactate dehydrogenase; lactoylglutathione lyase, or glyoxalase I; malate dehydrogenase; malate synthase; methanol:5-hydroxybenzimidazolylcobamide Comethyltransferase; mevalonate kinase; murine leukemia virus reverse transcriptase; myosin ATPase; NAD(P)+ transhydrogenase; Na+/K+-exchanging ATPase; neuraminidase; NMN nucleosidase, weakly inhibited; nucleoside-diphosphatase; pancreatic ribonuclease, or ribonuclease A; phenol 2- monooxygenase; phenol sulfotransferase, or aryl sulfotransferase; phenylalanyl-tRNA synthetase; phosphoenolpyruvate carboxylase; phosphofructokinase; phosphogluconate dehydrogenase; phosphoglucose isomerase; 3- phosphoglycerate kinase; phospholipase C; phosphomevalonate kinase; phosphopantothenoylcysteine decarboxylase (117,118,153- 155); phosphoribulokinase; porphobilinogen synthase, or daminolevulinate dehydratase; pyridoxamine:oxaloacetate aminotransferase; pyridoxine 4-oxidase; pyruvate dehydrogenase; pyruvate kinase; pyruvate,orthophosphate dikinase (123.124); retinal oxidase; ribonuclease A; ribonucleoside-diphosphate reductase; ribosomal proteins; ribulose-1,5-bisphosphate carboxylase; RNA-directed DNA polymerase, or reverse transcriptase; RNA polymerase; serine-sulfate ammonia-lyase; starch phosphorylase; starch synthase; succinic-semialdehyde dehydrogenase; thiamin-phosphate pyrophosphorylase; thymidylate synthase; tissue-specific transcription factor HNF1; tryptophanase; tryptophan synthase; uracilylalanine synthase; urocanase; uroporphyrinogen-III synthase; xanthine dehydrogenase, Drosophila melanogaster.

Pyridoxal 5’-Phosphate Preparation Products And Raw materials

Raw materials

Preparation Products

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Pyridoxal 5’-Phosphate Suppliers

Chengdu XiYa Chemical Technology Co., Ltd.
Tel
;
Fax
0539-6365991
Email
sale@xiyashiji.com;3007716753@qq.com
Country
China
ProdList
10578
Advantage
57
Syntechem Co.,Ltd
Tel
Please Email
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
13009
Advantage
57
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85561039- ;0731-85561020- ;0731-85561039-
Email
3002732518@qq.com;3002708854@qq.com;3002778010@qq.com
Country
China
ProdList
3388
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62
S.Z. PhyStandard Bio-Tech. Co., Ltd.
Tel
;
Fax
0755 28094224
Email
3001280422@qq.com;marketing@phystandard.com
Country
China
ProdList
5090
Advantage
50
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725;010-86181995
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12341
Advantage
58
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9914
Advantage
58
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
021-20337333-801
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
24981
Advantage
65
Shanghai Yolne Chemical Co., Ltd.
Tel
021-62960152;021-62960152
Fax
021-52212593
Email
sales@yolne.com;sales@yolne.com
Country
China
ProdList
9919
Advantage
55
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399-
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4575
Advantage
55
Shanghai TaoShu Biochemical Technology Co., Ltd.
Tel
021-33632979-
Fax
021-33632979
Email
service1@targetmol.com
Country
China
ProdList
4995
Advantage
58
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View Lastest Price from Pyridoxal 5’-Phosphate manufacturers

Career Henan Chemical Co
Product
Pyridoxal 5’-Phosphate 853645-22-4
Price
US $6.68/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
1kg-1000kg
Release date
2020-01-08

853645-22-4, Pyridoxal 5’-PhosphateRelated Search:


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