ChemicalBook > CAS DataBase List > 2-FORMYL-5-PICOLINE

2-FORMYL-5-PICOLINE

Product Name
2-FORMYL-5-PICOLINE
CAS No.
4985-92-6
Chemical Name
2-FORMYL-5-PICOLINE
Synonyms
2-FORMYL-5-PICOLINE;5-Methylpicolinaldehyde;5-METHYL-2-PYRIDINALDEHYDE;5-Methylpyridine-2-carboxaldehyde;5-methyl-2-pyridinecarboxaldehyde;2-Pyridinecarboxaldehyde,5-Methyl-;5-Methylpyridine-2-carboxaldehydet;2-FORMYL-5-PICOLINE ISO 9001：2015 REACH
CBNumber
CB6432768
Molecular Formula
C7H7NO
Formula Weight
121.14
MOL File
4985-92-6.mol
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2-FORMYL-5-PICOLINE Property

Melting point:
41.5 °C
Boiling point:
70-72 °C(Press: 0.7 Torr)
Density 
1.095±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
form 
solid
pka
4.01±0.10(Predicted)
Appearance
Off-white to light yellow <41.5°C Solid,>41.5°C Liquid
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Safety

Hazard Codes 
Xn
Risk Statements 
22
HazardClass 
IRRITANT
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SYX00325
Product name
5-Methylpyridine-2-carboxaldehyde
Packaging
1g
Price
$179
Updated
2025/07/31
TRC
Product number
M321390
Product name
5-Methylpicolinaldehyde
Packaging
100mg
Price
$75
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
Y14231
Product name
5-Methylpyridine-2-carboxaldehyde
Purity
98%
Packaging
1g
Price
$20
Updated
2021/12/16
AK Scientific
Product number
W6532
Product name
5-Methylpyridine-2-carbaldehyde
Packaging
5g
Price
$101
Updated
2021/12/16
Matrix Scientific
Product number
063862
Product name
5-Methylpyridine-2-carbaldehyde
Packaging
25g
Price
$259
Updated
2021/12/16
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2-FORMYL-5-PICOLINE Chemical Properties,Usage,Production

Synthesis

3510-66-5

68-12-2

4985-92-6

General procedure for the synthesis of 5-methylpyridine-2-aldehyde from 2-bromo-5-methylpyridine and N,N-dimethylformamide: 50 g (290 mmol) of 2-bromo-5-methylpyridine was dissolved in 2500 mL of diethyl ether and cooled to -78 °C. Subsequently, 150 mL (380 mmol) of n-butyllithium (nBuLi) was slowly added dropwise and the reaction mixture was stirred at -78 °C for 2 hours. Next, 31.5 mL (407 mmol) of N,N-dimethylformamide (DMF) was slowly added and the reaction mixture was allowed to gradually warm up to room temperature. Upon completion of the reaction, water was added to the mixture for quenching. The organic and aqueous layers were separated and the aqueous layer was extracted three times with ethyl acetate. All organic layers were combined, washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to remove the solvent to give a brown oil. The residue was purified by fast column chromatography (eluent: heptane/ethyl acetate, gradient 0 to 25% ethyl acetate) to give 19 g (39% yield) of brown solid product. Mass spectrum (APCI): m/z 122 ([M+H]+). 1H NMR (CDCl3, 360 MHz) δ (ppm): 2.48 (s, 3H, CH3); 7.70 (dd, J = 7.9, 2.0 Hz, 1H, pyridine H4); 7.91 (d, J = 7.7 Hz, 1H, pyridine H3); 8.68 (s, 1H, pyridine H6); 10.10 (s, 1H, aldehyde group).

References

[1] Angewandte Chemie - International Edition, 2018, vol. 57, # 8, p. 2238 - 2243
[2] Angew. Chem., 2018, vol. 130, # 8, p. 2260 - 2265,6
[3] Patent: WO2009/60030, 2009, A1. Location in patent: Page/Page column 38-39
[4] Chemistry - A European Journal, 2008, vol. 14, # 17, p. 5313 - 5328
[5] Bioorganic and Medicinal Chemistry, 2005, vol. 13, # 24, p. 6763 - 6770

2-FORMYL-5-PICOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-FORMYL-5-PICOLINE Suppliers

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View Lastest Price from 2-FORMYL-5-PICOLINE manufacturers

Dideu Industries Group Limited
Product
2-FORMYL-5-PICOLINE 4985-92-6
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons min
Release date
2021-08-27
Career Henan Chemical Co
Product
2-FORMYL-5-PICOLINE 4985-92-6
Price
US $1.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
200kg
Release date
2018-12-19

4985-92-6, 2-FORMYL-5-PICOLINERelated Search:

PYRIDINE-3,4-DICARBOXYLIC ANHYDRIDE 2,5-PYRIDINEDICARBOXYLIC ACID 4-(METHOXYCARBONYL)NICOTINIC ACID DIETHYL 3 4-PYRIDINEDICARBOXYLATE 97 Pyridoxal hydrochloride DIMETHYL PYRIDINE-2,5-DICARBOXYLATE 4-Pyridoxic acid THIOSTREPTON Pyrroloquinoline quinone 5-(Methoxycarbonyl)pyridine-2-carboxylic acid 2,5-PYRIDINEDICARBOXYLIC ACID DI-N-PROPYL ESTER Pyridoxal 5'-phosphate monohydrate 3,4-PYRIDINEDICARBOXIMIDE 3,4-Pyridinedicarboxylic acid ETHYL 2-CHLORO-3-CYANO-6-METHYLISONICOTINATE 5-ETHYLPYRIDINE-2,3-DICARBOXYLIC ACID FUSARIC ACID Ethyl 3-cyano-2-mercapto-6-methylisonicotinate

  • 5-METHYL-2-PYRIDINALDEHYDE
  • 2-FORMYL-5-PICOLINE
  • 5-Methylpyridine-2-carboxaldehyde
  • 5-Methylpicolinaldehyde
  • 5-Methylpyridine-2-carboxaldehydet
  • 2-Pyridinecarboxaldehyde,5-Methyl-
  • 5-methyl-2-pyridinecarboxaldehyde
  • 2-FORMYL-5-PICOLINE ISO 9001：2015 REACH
  • 4985-92-6
  • Pyridines
  • Pyridine
  • Heterocycle-Pyridine series