ChemicalBook > CAS DataBase List > 2-METHYL-4-HYDROXYMETHYLPYRIDINE

2-METHYL-4-HYDROXYMETHYLPYRIDINE

Product Name: 2-METHYL-4-HYDROXYMETHYLPYRIDINE
CAS No.: 105250-16-6
Chemical Name: 2-METHYL-4-HYDROXYMETHYLPYRIDINE
Synonyms: 2-Methyl-4-pyridinemethanol;(2-Methyl-4-pyridyl)methanol;4-Pyridinemethanol, 2-methyl-;(2-Methylpyridin-4-yl)methanol;(2-methyl-4-pyridinyl)methanol;(2-Methylpyridine-4-yl)methanol;2-METHYL-4-HYDROXYMETHYLPYRIDINE;4-Pyridinemethanol,2-methyl-(9CI);4-(Hydroxymethyl)-2-methylpyridine;2-METHYL-4-HYDROXYMETHYLPYRIDINE ISO 9001：2015 REACH
CBNumber: CB9363544
Molecular Formula: C7H9NO
Formula Weight: 123.15
MOL File: 105250-16-6.mol

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2-METHYL-4-HYDROXYMETHYLPYRIDINE Property

Boiling point:: 131-140 °C(Press: 4 Torr)
Density: 1.092±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
pka: 13.46±0.10(Predicted)
form: powder
color: Pale yellow

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22-36/37/38
Safety Statements: 26-36
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: L499730
Product name: 2-Methyl-4-hydroxymethylpyridine
Purity: Aldrich<sup>CPR</sup>
Packaging: 1 unit
Price: $113
Updated: 2025/07/31

Sigma-Aldrich

Product number: L499730
Product name: 2-Methyl-4-hydroxymethylpyridine
Purity: Aldrich
Packaging: 250mg
Price: $110
Updated: 2024/03/01

TRC

Product number: M322180
Product name: (2-Methylpyridin-4-yl)methanol
Packaging: 50mg
Price: $45
Updated: 2021/12/16

TRC

Product number: M322180
Product name: (2-Methylpyridin-4-yl)methanol
Packaging: 500mg
Price: $200
Updated: 2021/12/16

Matrix Scientific

Product number: 069912
Product name: 2-Methyl-4-hydroxymethylpyridine
Purity: 98%
Packaging: 500mg
Price: $150
Updated: 2021/12/16

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2-METHYL-4-HYDROXYMETHYLPYRIDINE Chemical Properties,Usage,Production

Synthesis Reference(s)

Synthesis, p. 483, 2002 DOI: 10.1055/s-2002-20960

Synthesis

152815-18-4

105250-16-6

General procedure for the synthesis of 2-methyl-4-hydroxymethylpyridine from (2-chloro-6-methylpyridin-4-yl)methanol: In a variant of the method described above, 2-chloro-6-methylpyridine-4-carboxylic acid, palladium catalyst (0.20 g, 10 mol% loaded on carbon), ethyl acetate (45 mL) and triethylamine (2.8 mL, 20 mmol) were mixed. The reaction mixture was placed under a hydrogen atmosphere at 1 atmosphere for 21 hours. Subsequently, additional Pearlman catalyst (0.2 g) was added and the reaction continued to be stirred for 5 hours under a hydrogen atmosphere to achieve dechlorination. Upon completion of the reaction, the mixture was filtered through a diatomaceous earth pad and the filtrate was concentrated. Purification by column chromatography (eluent ratio 5:95 methanol:dichloromethane) afforded (2-methylpyridin-4-yl)methanol (1.48 g, 88% yield). The obtained (2-methylpyridin-4-yl)methanol can be used to prepare 2-amino-3-(2-methylpyridin-4-yl)propionitrile, and 1-methyl-1H-indol-2-one carboxylic acid ((1S,2R)-2-{[cyano -(2-methylpyridin-4-ylmethyl)-methyl]-carbamoyl}-cyclohexyl)amide obtained by the method described above (186 mg, yield 62%). Results of mass spectrometry analysis: m/z 444 (M+H).

References

[1] Patent: US2004/77646, 2004, A1. Location in patent: Page 116

2-METHYL-4-HYDROXYMETHYLPYRIDINE Preparation Products And Raw materials

Raw materials

Nitrogen Ethanol 2,4-Lutidine Sodium chloride Sodium borohydride Diethylamine DIMETHYLFORMAMIDE HYDROGEN CHLORIDE COMPLEX Tetrahydrofuran Ammonium chloride Dichloromethane Methanol Sodium periodate Magnesium sulfate n-Butyllithium

Preparation Products

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View Lastest Price from 2-METHYL-4-HYDROXYMETHYLPYRIDINE manufacturers

Dideu Industries Group Limited

Product: 2-METHYL-4-HYDROXYMETHYLPYRIDINE 105250-16-6
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-09-27

105250-16-6, 2-METHYL-4-HYDROXYMETHYLPYRIDINERelated Search:

2,2'-BIQUINOLINE-4,4'-DICARBOXYLIC ACID DIPOTASSIUM SALT TRIHYDRATE 3-Hydroxy-2-methyl-4-quinolinecarboxylic acid 4-Pyridoxic acid Pyridoxine hydrochloride CINCHOPHEN Bicinchoninic Acid Disodium Salt 2,4-Pyridinedicarboxylic acid ETHYL 2-CHLORO-3-CYANO-6-METHYLISONICOTINATE 2,2'-Bipyridine-4,4'-dicarboxylic acid oxycinchophen Pyridoxine Pyrroloquinoline quinone 6-CHLORO-2-(4-CHLOROPHENYL)-4-QUINOLINE CARBOXYLIC ACID Dimethyl 2,4-pyridinedicarboxylate 2-PHENYL-QUINOLINE-4-CARBOXYLIC ACID METHYL ESTER 6-METHOXY-2-PHENYL-4-QUINOLINECARBOXYLIC ACID NEOCINCHOPHEN 2-(3-CARBOXY-4-HYDROXYPHENYL) QUINOLINE-4-CARBOXYLIC ACID

(2-methyl-4-pyridinyl)methanol

2-METHYL-4-HYDROXYMETHYLPYRIDINE

4-Pyridinemethanol,2-methyl-(9CI)

(2-Methylpyridin-4-yl)methanol

4-(Hydroxymethyl)-2-methylpyridine

(2-Methylpyridin-4-yl)methanol, 4-(Hydroxymethyl)-2-picoline

(2-Methyl-4-pyridyl)methanol

4-Pyridinemethanol, 2-methyl-

2-METHYL-4-HYDROXYMETHYLPYRIDINE ISO 9001：2015 REACH

2-Methyl-4-pyridinemethanol

(2-Methylpyridine-4-yl)methanol

105250-16-6

PYRIDINE