Cysteamine bitartrate Chemical Properties

storage temp. 

Store at -20°C

solubility 

DMSO: 45 mg/mL (198.03 mM);Ethanol: Insoluble

Water Solubility 

Water: 45 mg/mL (198.03 mM)

InChI

InChI=1/C4H6O6.C2H7NS/c5-1(3(7)8)2(6)4(9)10;3-1-2-4/h1-2,5-6H,(H,7,8)(H,9,10);4H,1-3H2/t1-,2-;/s3

InChIKey

NSKJTUFFDRENDM-RZHFEHKBNA-N

SMILES

C(N)CS.[C@H](O)(C(=O)O)[C@@H](O)C(=O)O |&1:4,9,r|

Cysteamine bitartrate Usage And Synthesis

Description

Cysteamine bitartrate is an amino thiol and a byproduct of the cysteine degradation pathway that is an FDA-approved therapy for the treatment of nephropathic cystinosis to decrease the accumulation of lysosomal cystine (the disulfide-linked form of cysteine) by engaging in disulfide exchange. In addition, cysteamine bitartrate has been postulated to have broader antioxidant properties potentially related to a distinct role in increasing cysteine availability to support the biosynthesis of the potent antioxidant molecule glutathione[1].

References

[1] Sujay Guha. “Pre-clinical evaluation of cysteamine bitartrate as a therapeutic agent for mitochondrial respiratory chain disease.” Human molecular genetics (2019): 1837–1852.

Uses

Cysteamine bitartrate (CAS# 27761-19-9) treatment of cystinosis and other metabolic and neurodegenerative diseases.

Cysteamine bitartrate(27761-19-9)Related Product Information

• AMMONIUM HYDROGEN TARTRATE