2-bromo-3-methylacetophenone Chemical Properties

Boiling point:

120-122 °C(Press: 1.5 Torr)

Density 

1.416±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

Appearance

Colorless to light yellow ＜47℃ Solid,＞48℃ Liquid

InChI

InChI=1S/C9H9BrO/c1-7-3-2-4-8(5-7)9(11)6-10/h2-5H,6H2,1H3

InChIKey

BANFRNTVKCHZDE-UHFFFAOYSA-N

SMILES

C(=O)(C1=CC=CC(C)=C1)CBr

2-bromo-3-methylacetophenone Usage And Synthesis

Synthesis

General procedure for the synthesis of 2-bromo-1-(3-methylphenyl)ethyl-1-one from 1-(bromoethynyl)-3-methylbenzene: A mixed solution of 1-(bromoethynyl)-3-methylbenzene (0.5 mmol), AgF (5 mol%), and water (1 eq.) in TFA (1 mL) was stirred and reacted for 6 hours at 40 °C. Upon completion of the reaction, the TFA was recovered by distillation for reuse. The reaction mixture was purified by column chromatography to afford the target product 2-bromo-1-(3-methylphenyl)ethyl-1-one.

References

[1] European Journal of Organic Chemistry, 2016, vol. 2016, # 1, p. 116 - 121
[2] Tetrahedron Letters, 2014, vol. 55, # 7, p. 1373 - 1375
[3] Journal of Organic Chemistry, 2013, vol. 78, # 18, p. 9190 - 9195
[4] Tetrahedron Letters, 2016, vol. 57, # 45, p. 4983 - 4986
[5] Tetrahedron, 2016, vol. 72, # 27-28, p. 3818 - 3822

2-bromo-3-methylacetophenone (51012-64-7)Related Product Information

• 2-bromo-2-methylacetophenone
• 2,2-DIBROMO-1-P-TOLYLETHANONE
• Zolpidem Impurity 29
• Zolpidem Impurity 18
• Methyl 6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-acetate
• Tolyloyl propionamide
• 8-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine
• Zolpidem Impurity 31
• Zolpidem Impurity 35
• 6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]-pyridine-3-acetic acid
• Benzenebutanamide, β-bromo-N,N,4-trimethyl-γ-oxo-
• Zolpidem Impurity 46
• Hydroxy[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetic acid
• Zolpidem Impurity 38
• 7-methyl-2-(p-tolyl)imidazo[1,2-a]pyridine
• 6-Methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine
• Zolpidem tartrate
• 6-Methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-acetamide