2-Thiohydantoin Chemical Properties

Melting point:

229-231 °C (dec.)(lit.)

Density 

1.346 (estimate)

vapor density 

4 (vs air)

refractive index 

1.6550 (estimate)

storage temp. 

Room Temperature

solubility 

DMSO (Slightly), Methanol (Slightly)

pka

8.50±0.10(Predicted)

form 

Crystalline Powder

color 

White

CAS DataBase Reference

503-87-7(CAS DataBase Reference)

NIST Chemistry Reference

4-Imidazolidinone, 2-thioxo-(503-87-7)

EPA Substance Registry System

4-Imidazolidinone, 2-thioxo- (503-87-7)

Safety Information

Hazard Codes 

Xn

Risk Statements 

20/21/22-22

Safety Statements 

36

WGK Germany 

3

RTECS 

MU4200000

TSCA 

Yes

HS Code 

2934999090

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2-Thiohydantoin Usage And Synthesis

Chemical Properties

BROWN CRYSTALLINE POWDER

Uses

Reactant for synthesis of:• ;Drugs with antidiabetic activity1• ;Barbituric acid and thiohydantoin derivatives with antimicrobial activity2• ;Possible anticancer agents3• ;Fibroblast growth factor receptor 1 kinase inhibitors4• ;HIV-1 integrase inhibitors5Reactant for persilylation6

Uses

2-Thiohydantoin is a useful synthetic intermediate. It is a reactant for synthesis of drugs with antidiabetic activity, barbituric acid and thiohydantoin derivatives with antimicrobial activity, and possible anticancer agents.

Uses

Reactant for synthesis of:

• Drugs with antidiabetic activity
• Barbituric acid and thiohydantoin derivatives with antimicrobial activity
• Possible anticancer agents
• Fibroblast growth factor receptor 1 kinase inhibitors
• HIV-1 integrase inhibitors

2-Thiohydantoin(503-87-7)Related Product Information

• Sodium thiosulfate
• BCDMH
• Iprodione
• Thioacetamide
• Phenytoin sodium
• Thioacetic acid
• 1,3-Dibromo-5,5-dimethylhydantoin
• 2-Thiobarbituric acid
• Dimethyloldimethyl hydantoin
• Hydantoin
• 3-PHENYL-2-THIOHYDANTOIN-5-ACETIC ACID
• Pseudothiohydantoin
• 1,3-DIMETHYL-2-THIOHYDANTOIN 98+%,1,3-DIMETHYL-2-THIOHYDANTOIN
• Allantoin
• 1-ACETYL-2-THIOHYDANTOIN
• PTH-SERINE
• 5-(3-INDOLYLMETHYL)-3-PHENYL-2-THIOHYDANTOIN
• 5-ISOBUTYL-3-PHENYL-2-THIOHYDANTOIN