5-(2,2,3-Trimethyl-3-cyclopentenyl)-3-methyl-pentan-2-ol Chemical Properties

Boiling point:

275.8±9.0 °C(Predicted)

Density 

0.895-0.904

refractive index 

1.4700-1.4760

Flash point:

>100°C

storage temp. 

Refrigerator

solubility 

DMSO, Methanol, Pyridine

form 

Oil

pka

15.09±0.20(Predicted)

color 

Clear Colourless

Odor

at 100.00 %. sweet sandalwood woody waxy greasy creamy amyris

Odor Type

woody

LogP

4.587 (est)

EPA Substance Registry System

3-Cyclopentene-1-butanol, .alpha.,.beta.,2,2,3-pentamethyl- (65113-99-7)

5-(2,2,3-Trimethyl-3-cyclopentenyl)-3-methyl-pentan-2-ol Usage And Synthesis

Chemical Properties

5-(2,2,3-Trimethyl-3-cyclopentenyl)-3-methyl-pentan-2-ol is prepared by condensation of α-campholenaldehyde with methyl ethyl ketone, followed by selective hydrogenation of the resulting unsaturated ketone.
The title compound can be used either in a pure state or as a mixture with its isomeric by-product in perfume compositions and soap perfumes.

Uses

Sandalore is a property in structure in relation to sandalwood odor. It has been found that hair follicles treated with sandalore increases the expression of the olfactory receptor OR2AT4 resulting in prolongation of the follicles’ growth phase. Sandalore also promotes skin-cell proliferation and wound healing.

Trade name

Sandalore® (Givaudan)

Biological Activity

Sandalore is an agonist of olfactory receptor OR2AT4, a G-protein-coupled receptor (GPCR) also expressed in human primary keratinocytes. Sandalore was shown to enhance hair growth in human scalp hair follicles by stimulating OR2AT4, resulting in decreased apoptosis and increased production of the anagen-prolonging growth factor IGF-1. Sandalore had previously been shown to increase wound healing. Sandalore was also recently used to study OR2AT4 found in the human chronic myelogenous leukemia (CML) cell line K562 and in white blood cells of clinically diagnosed acute myeloid leukemia (AML) patients.

5-(2,2,3-Trimethyl-3-cyclopentenyl)-3-methyl-pentan-2-ol (65113-99-7)Related Product Information

• METSULFURON METHYL
• Methyl cyclopentenolone
• Norandrostenedione
• Methylparaben
• METHYLCYCLOPENTADIENE DIMER
• Diniconazole
• Methyl cellulose
• Methanol
• Methyl acrylate
• Allyl methacrylate
• Kresoxim-methyl
• Dicyclopentadiene
• 6-Methyl-5-hepten-2-one
• FEMA 3005
• Bensulfuron methyl
• Sandenol
• Sandalmysore Core
• Methyl