H-TRP-PHE-TYR-SER(PO3H2)-PRO-ARG-PNA Chemical Properties

Density 

1.53±0.1 g/cm3(Predicted)

storage temp. 

-15°C

pka

1.80±0.10(Predicted)

Sequence

Trp-Phe-Tyr-{PO2}-Ser-Pro-Arg

H-TRP-PHE-TYR-SER(PO3H2)-PRO-ARG-PNA Usage And Synthesis

Uses

H-Trp-Phe-Tyr-Ser(PO3H2)-Pro-Arg-pNA is a chromogenic substrate for Pin1. Pin1 is an essential and conserved mitotic peptidyl-prolyl isomerase, and can recognize the phosphoserine-proline bonds present in mitotic phosphoproteins[1][2].

References

[1] M B Yaffe, et al. Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism. Science. 1997 Dec 12;278(5345):1957-60. DOI:10.1126/science.278.5345.1957
[2] Kelly E Duncan, et al. Discovery and characterization of a nonphosphorylated cyclic peptide inhibitor of the peptidylprolyl isomerase, Pin1. J Med Chem. 2011 Jun 9;54(11):3854-65. DOI:10.1021/jm200156c

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