Dopropidil
Dopropidil Basic information
- Product Name:
- Dopropidil
- Synonyms:
-
- Dopropidil
- 4205CERM
- Pyrrolidine, 1-[1-[(2-methylpropoxy)methyl]-2-[[1-(1-propyn-1-yl)cyclohexyl]oxy]ethyl]-
- CAS:
- 79700-61-1
- MF:
- C20H35NO2
- MW:
- 321.501
- Mol File:
- 79700-61-1.mol
Dopropidil Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
Dopropidil Usage And Synthesis
Uses
Dopropidil is a novel anti-anginal calcium ion modulating agent, possessing intracellular calcium antagonist activity and anti-ischemic effects in several predictive animal models.
in vivo
Dopropidil (1 and 2.5 mg/kg) dose-dependently reduces the electrical (ST segment elevation), biochemical (lactate production and potassium release), and mechanical (loss in myocardial segment contractility) perturbations induced by ischemia in the anesthetized dog. Intraduodenal administration of Dopropidil (50 mg/kg) significantly reduces isoproterenol-induced tachycardia. This effect is manifest at 15-120 min following administration of the compound which indicates a rapid absorption and a long duration of action. In conscious dogs Dopropidil (12-14 mg/kg p.o.) reduces resting heart rate by approximately10 beats/min[1].
References
[1] J. Planellas, et al. Dopropidil, A Novel Antianginal Calcium Modulating Agent. Cardiovascular Drug Reviews. Vol.12, No.3, pp. 208-224.
DopropidilSupplier
- Tel
- 021-58955995
- sales@medchemexpress.cn
- Tel
- 15911056312
- liming@bio-fount.com
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Tel
- info@bocsci.com
- Tel
- 010-60605840 15801484223;
- psaitong@jm-bio.com