Pomisartan
Pomisartan Basic information
- Product Name:
- Pomisartan
- Synonyms:
-
- Pomisartan
- 4'-((2-Ethyl-4-methyl-6-(5,6,7,8-tetrahydroimidazo(1,2-A)pyridin-2-yl)-1-benzimidazolyl)methyl)-2-biphenylcarboxylic acid
- Pomisartan [inn]
- Unii-7539319jyi
- [1,1'-Biphenyl]-2-carboxylic acid, 4'-[[2-ethyl-4-methyl-6-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)-1H-benzimidazol-1-yl]methyl]-
- BIBR 363
- BIBR363
- BIBR-363
- CAS:
- 144702-17-0
- MF:
- C31H30N4O2
- MW:
- 490.6
- Mol File:
- 144702-17-0.mol
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Pomisartan Chemical Properties
- Boiling point:
- 779.5±60.0 °C(Predicted)
- Density
- 1.27±0.1 g/cm3(Predicted)
- pka
- 3.86±0.36(Predicted)
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Pomisartan Usage And Synthesis
Uses
Pomisartan is an orally active angiotensin II receptor type AT1 antagonist (IC50=0.26 μM). Pomisartan works by inhibiting the binding of angiotensin II to the AT1 receptor, thereby blocking the vasoconstriction and aldosterone release caused by this interaction. Pomisartan results in a blood pressure-lowering effect[1].
References
[1] Krovat EM, et al. Non-peptide angiotensin II receptor antagonists: chemical feature based pharmacophore identification. J Med Chem. 2003 Feb 27;46(5):716-26. DOI:10.1021/jm021032v
PomisartanSupplier
TargetMol Chemicals Inc.
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Suzhou Meishi Biotechnology Co., Ltd.
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Shanghai Yifei Biotechnology Co. , Ltd.
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- 021-65675885 18964387627
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TargetMol Chemicals Inc.
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- 15002134094
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Sangon Biotech (Shanghai) Co.,Ltd.
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- 400-821-026
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