2,2,2-TRIFLUOROETHANETHIOL Chemical Properties

Melting point:

51.3-52.3 °C

Boiling point:

34-35 °C (lit.)

Density 

1.305 g/mL at 25 °C (lit.)

vapor pressure 

7.85 psi ( 20 °C)

refractive index 

n20/D 1.352(lit.)

Flash point:

−11 °F

pka

7.60±0.10(Predicted)

form 

liquid

InChI

1S/C2H3F3S/c3-2(4,5)1-6/h6H,1H2

InChIKey

RYRLLAOLJVDVNN-UHFFFAOYSA-N

SMILES

FC(F)(F)CS

Safety Information

Hazard Codes 

F+,Xn

Risk Statements 

12-20/21/22-36/37/38

Safety Statements 

16-33-38

RIDADR 

UN 3336 3/PG 1

WGK Germany 

3

HazardClass 

3.1

PackingGroup 

I

Storage Class

3 - Flammable liquids

Hazard Classifications

Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Eye Irrit. 2
Flam. Liq. 1
Skin Irrit. 2
STOT SE 3

MSDS

• Language:English Provider:SigmaAldrich

2,2,2-TRIFLUOROETHANETHIOL Usage And Synthesis

Uses

• Advancements in Peptide Synthesis: A novel synthesis of β-thiol phenylalanine showcases the use of 2,2,2-Trifluoroethanethiol in facilitating one-pot ligation-desulfurization chemistry. This technique is pivotal for developing new peptide-based pharmaceuticals, enhancing both the efficiency and versatility of peptide synthesis (Malins et al., 2015).

General Description

2,2,2-Trifluoroethanethiol is basic in nature and forms charge transfer complexes with molecular iodine.

2,2,2-TRIFLUOROETHANETHIOL(1544-53-2)Related Product Information

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