Basic information Safety Supplier Related

Defosfamide

Basic information Safety Supplier Related

Defosfamide Basic information

Product Name:
Defosfamide
Synonyms:
  • Defosfamide
  • B 612
  • B-612
  • Desmofosfamide
  • Desmophosphamidum
  • Mitarson
  • 3-[[bis(2-chloroethyl)amino-(2-chloroethoxy)phosphoryl]amino]propan-1-ol
  • Phosphorodiamidic acid, N,N-bis(2-chloroethyl)-N'-(3-hydroxypropyl)-, 2-chloroethyl ester
CAS:
3733-81-1
MF:
C9H20Cl3N2O3P
MW:
341.6
Mol File:
3733-81-1.mol
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Defosfamide Chemical Properties

Boiling point:
442.8±55.0 °C(Predicted)
Density 
1.337±0.06 g/cm3(Predicted)
pka
14.92±0.10(Predicted)
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Defosfamide Usage And Synthesis

Originator

Mitarson,Asta-Werke,W. Germany,1961

Manufacturing Process

A solution of 8 g of ethylene chlorohydrin and 10.2 g of triethylamine in 50 cc of absolute dioxane is slowly added dropwise to a solution of 25.9 g of N,Nbis-(β-chloroethyl)-phosphoric acid amide dichloride in 100 cc of absolute dioxane. The mixture is then heated for 2 hours at 60°C. After cooling, a solution of 7.5 g of 1,3-propanolamine and 10.2 g of triethylamine in 50 cc of absolute dioxane is added dropwise while stirring well and at a temperature up to 30°C. The mixture is left to stand for another 12 hours. The liquid is filtered off with suction from the precipitated triethyamine hydrochloride. The filtrate is filtered through carbon and concentrated by evaporation in water-jet vacuum at 40°C. The residue is dissolved in a little alcohol. Copious amounts of ether are added and the solution is left overnight in a refrigerator. It is then again filtered through carbon, the ether is evaporated and the residual volatile fractions are removed under high vacuum at 55°C. The result is a yellowish, fairly viscous oil, which is insoluble in water.

Therapeutic Function

Antineoplastic

DefosfamideSupplier

Career Henan Chemica Co
Tel
+86-0371-86658258 15093356674;
Email
laboratory@coreychem.com
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Defosfamide(3733-81-1)Related Product Information