Imipenem-Cilastatin sodium hydrate
Imipenem-Cilastatin sodium hydrate Basic information
- Product Name:
- Imipenem-Cilastatin sodium hydrate
- Synonyms:
-
- Primaxin
- Thienam
- Tienam 500
- IMipeneM and Cilastatin SodiuM with SodiuM Bicarbonate
- 7-[(2S)-2-amino-2-carboxy-ethyl]sulfanyl-2-[[(1S)-2,2-dimethylcyclopro panecarbonyl]amino]hept-2-enoic acid: (5R)-3-[2-(aminomethylideneamino )ethylsulfanyl]-6-(1-hydroxyethyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene -2-carboxylic acid
- Imipenem-Cilastatin sodium hydrate
- Sodium (Z)-7-[(2R)-2-amino-3-hydroxy-3-oxopropyl]sulfanyl-2-[[(1S)-2,2-dimethylcyclopropanecarbonyl]amino]hept-2-enoate (5R,6S)-3-[2-(aminomethylideneamino)ethylsulfanyl]-6-(1-hydroxyethyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid hydrate
- 1-Azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 6-((1R)-1-hydroxyethyl)-3-((2-((iminomethyl)amino)ethyl)thio)-7-oxo-, (5R,6S)-, mixt. with (2Z)-7-(((2R)-2-amino-2-carboxyethyl)thio)-2-((((1S)-2,2-dimethylcyclopropyl)carbonyl)amino)-2-heptenoic acid
- CAS:
- 92309-29-0
- MF:
- C28H43N5O9S2
- MW:
- 657.8
- EINECS:
- 1592732-453-0
- Mol File:
- 92309-29-0.mol
Imipenem-Cilastatin sodium hydrate Usage And Synthesis
Clinical Use
Antibacterial agent
Drug interactions
Potentially hazardous interactions with other drugs
Antiepileptics: reduced valproate concentration -
avoid.
Antivirals: convulsions reported with concomitant
administration of ganciclovir and valganciclovir.
Ciclosporin: variable reports of increase / no change
in ciclosporin levels, and of neurotoxicity.
Metabolism
When administered alone, imipenem is metabolised in the kidneys by dehydropeptidase-I, an enzyme in the brush border of the renal tubules, to inactive, nephrotoxic metabolites, with only about 5 to 40 or 45% of a dose excreted in the urine as unchanged active drug. Cilastin inhibits the metabolism of imipenem. When given with cilastatin about 70% of an intravenous dose of imipenem is recovered unchanged in the urine within 10 hours. Cilastatin is also excreted mainly in the urine, the majority as unchanged drug and about 12% as N-acetyl cilastatin. Less than 1% of imipenem is excreted via the bile in the faeces.
Imipenem-Cilastatin sodium hydrateSupplier
- Tel
- 0411-62910999 13889544652
- meilunui@163.com
- Tel
- 021-61552785
- sales@shshiji.com
- Tel
- 020-39119399 18927568969
- isunpharm@qq.com
- Tel
- 400-0066400 13621662912
- 422131432@qq.com
- Tel
- 021-64609169 18901607656
- greensnown@163.com
Imipenem-Cilastatin sodium hydrate(92309-29-0)Related Product Information
- Sodium hydroxide
- Imipenem
- Sodium acetate
- Cilastatin
- Cilastatin sodium
- CHLOROPHOSPHONAZO III
- Sodium formate
- (5R,6S)-3-[(Diphenoxyphosphinyl)oxy]-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid (4-nitrophenyl)methyl ester
- Chloral hydrate
- Diclofenac sodium
- Sodium bicarbonate
- Imipenem
- Sodium gluconate
- Sodium benzoate
- Moxifloxacin hydrochloride
- hydrazine hydrate
- hydrate
- Imipenem-Cilastatin sodium hydrate