β-Lactamase inhibitors
The β-lactamase inhibitor is a class of agents that can inhibit the activity of β-lactamase and hence avert or reduce the hydrolysis of inner β-lactam. Used in combination with β-lactam antibiotics, it can inhibit drug resistant bacteria, extended their antibacterial spectrum and enhance their antibacterial activity. According to their acting mechanism, β-lactamase inhibitors are divided into competitive inhibitor and noncompetitive inhibitor.
Competitive inhibitors
① Reversible competitive inhibitors such as cl- oxacillin and dicloxacillin, etc.:They compete with inner β-lactam for the active site within the β-lactamase without chemical interactions. Once removed, β-lactamase will regain its activity.
② Irreversible competitive inhibitors such as clavulanic acid and penicillanic sulfone: they will cause irreversible chemical reactions with β-lactamase and inactivate the enzyme. Even after the remained irreversible competitive inhibitors removed, the enzyme cannot be reproduced.
Noncompetitive inhibitors
they don’t compete with the substrate for the binding sites within the enzyme, but bind themselves onto the sites far from the catalytic sites and metamorphosize the enzyme and hence inactivate it. Methicillin, one of inhibitors above, is a competitive inhibitor at low concentrations, but a noncompetitive inhibitor at high concentrations.
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- Structure:
- Chemical Name:
- Side chain for meropenem
- CAS:
- 96034-64-9
- MF:
- C15H19N3O5S
- Structure:
- Chemical Name:
- Cefaclor monohydrate
- CAS:
- 70356-03-5
- MF:
- C15H16ClN3O5S
- Structure:
- Chemical Name:
- Faropenem sodium hemipentahydrate
- CAS:
- 106560-14-9
- MF:
- C12H15NO5S
- Structure:
- Chemical Name:
- Sulbactam
- CAS:
- 68373-14-8
- MF:
- C8H11NO5S
- Structure:
- Chemical Name:
- Doripenem hydrate
- CAS:
- 364622-82-2
- MF:
- C15H26N4O7S2
- Structure:
- Chemical Name:
- Ertapenem
- CAS:
- 153832-46-3
- MF:
- C22H25N3O7S
- Structure:
- Chemical Name:
- Doripenem
- CAS:
- 148016-81-3
- MF:
- C15H24N4O6S2
- Structure:
- Chemical Name:
- 3-[[[(2S,4S)-4-Mercapto-1-(4-nitrobenzyloxy)carbonyl-2-pyrrolidinyl]carbonyl]amino]benzoic acid
- CAS:
- 202467-69-4
- MF:
- C20H19N3O7S
- Structure:
- Chemical Name:
- Cefozopran
- CAS:
- 113359-04-9
- MF:
- C19H17N9O5S2
- Structure:
- Chemical Name:
- BIAPENEM SIDE CHAIN
- CAS:
- 153851-71-9
- MF:
- C5H8ClN3S
- Structure:
- Chemical Name:
- Cefprozil hydrate
- CAS:
- 121123-17-9
- MF:
- C18H21N3O6S
- Structure:
- Chemical Name:
- Cilastatin
- CAS:
- 82009-34-5
- MF:
- C16H26N2O5S
- Structure:
- Chemical Name:
- Ticarcillin disodium salt
- CAS:
- 4697-14-7
- MF:
- C15H17N2NaO6S2
- Structure:
- Chemical Name:
- p-Nitrobenzyl-6-(1-hydroxyethyl)-1-azabicyclo(3.2.0)heptane-3,7-dione-2-carboxylate
- CAS:
- 74288-40-7
- MF:
- C16H16N2O7
- Structure:
- Chemical Name:
- Imipenem
- CAS:
- 74431-23-5
- MF:
- C12H19N3O5S
- Structure:
- Chemical Name:
- Meropenem
- CAS:
- 96036-03-2
- MF:
- C17H25N3O5S
- Structure:
- Chemical Name:
- Cefcapene pivoxil
- CAS:
- 105889-45-0
- MF:
- C23H29N5O8S2
- Structure:
- Chemical Name:
- ACS-PNZ-PYRROLIDYL-(BOC)-NSO2NH2
- CAS:
- 491878-06-9
- MF:
- C20H28N4O9S2
- Structure:
- Chemical Name:
- (2R,4S)-4-nitrobenzyl 4-Mercapto-2-((sulfaMoylaMino)Methyl)pyrrolidine-1-carboxylate
- CAS:
- 148017-03-2
- MF:
- C13H18N4O6S2
- Structure:
- Chemical Name:
- Sulbactam sodium
- CAS:
- 69388-84-7
- MF:
- C8H12NNaO5S
- Structure:
- Chemical Name:
- Aztreonam
- CAS:
- 78110-38-0
- MF:
- C13H17N5O8S2
- Structure:
- Chemical Name:
- Ertapenem sodium
- CAS:
- 153773-82-1
- MF:
- C22H26N3NaO7S
- Structure:
- Chemical Name:
- 3-(2-Bromo-1-oxopropyl)-spiro[2H-1,3-benzoxazine-2,1'-cyclohexan]-4(3H)-one
- CAS:
- 158299-05-9
- MF:
- C16H18BrNO3
- Structure:
- Chemical Name:
- Panipenem
- CAS:
- 87726-17-8
- MF:
- C15H21N3O4S
- Structure:
- Chemical Name:
- Protected Imipenem
- CAS:
- 98367-45-4
- MF:
- C27H27N5O10S
- Chemical Name:
- Cilastatin&imipenem
- Chemical Name:
- Sultamicillic tosylate
- Chemical Name:
- Cefoperazone sodium +sulbactam sodium(1:1/2:1)
- Structure:
- Chemical Name:
- (3S,4R)-3-[(1R)-1-Hydroxyethyl]-4-[(1R)-1-methyl-3-diazo-3-(p-nitrobenzyloxycarbonyl)-2-oxopropyl]azetidin-2-one
- CAS:
- 137391-68-5
- MF:
- C17H18N4O7
- Structure:
- Chemical Name:
- 3-Azetidinethiol, 1-(4,5-dihydro-2-thiazolyl)-, monohydrochloride
- CAS:
- 179337-57-6
- MF:
- C6H11ClN2S2
- Structure:
- Chemical Name:
- 1,2-Pyrrolidinedicarboxylic acid, 4-[(Methylsulfonyl)oxy]-, 2-Methyl 1-[(4-nitrophenyl)Methyl] ester, (2S,4R)-
- CAS:
- 138324-82-0
- MF:
- C15H18N2O9S
- Structure:
- Chemical Name:
- Sulbactam pivoxil
- CAS:
- 69388-79-0
- MF:
- C14H21NO7S
- Structure:
- Chemical Name:
- Potassium clavulanate
- CAS:
- 61177-45-5
- MF:
- C8H10KNO5
- Structure:
- Chemical Name:
- Cefuzonam
- CAS:
- 82219-78-1
- MF:
- C16H15N7O5S4
- Structure:
- Chemical Name:
- Ritipenem
- CAS:
- 84845-57-8
- MF:
- C10H12N2O6S
- Structure:
- Chemical Name:
- Imipenem-Cilastatin sodium hydrate
- CAS:
- 92309-29-0
- MF:
- C28H43N5O9S2
- Structure:
- Chemical Name:
- Tazobactam sodium
- CAS:
- 89785-84-2
- MF:
- C10H12N4NaO5S
- Structure:
- Chemical Name:
- Ertapenem Disodium
- CAS:
- 153832-38-3
- MF:
- C22H26N3NaO7S
- Structure:
- Chemical Name:
- (5R,6S)-3-[(Diphenoxyphosphinyl)oxy]-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid (4-nitrophenyl)methyl ester
- CAS:
- 75321-08-3
- MF:
- C28H25N2O10P
- Chemical Name:
- Clavulanate PotassiuM+Microcrystalline cellulose(1:1)
- Chemical Name:
- MeropeneM with SodiuM Carbonate
- Structure:
- Chemical Name:
- Faropenem daloxate
- CAS:
- 141702-36-5
- MF:
- C17H19NO8S
- Structure:
- Chemical Name:
- CARUMONAM
- CAS:
- 87638-04-8
- MF:
- C12H14N6O10S2
- Structure:
- Chemical Name:
- Tebipenem
- CAS:
- 161715-21-5
- MF:
- C16H21N3O4S2
- Structure:
- Chemical Name:
- Imipenem
- CAS:
- 64221-86-9
- MF:
- C12H17N3O4S
- Chemical Name:
- AMoxicillin and Clavulanate PotassiuM
- Structure:
- Chemical Name:
- Tazobactam acid
- CAS:
- 89786-04-9
- MF:
- C10H12N4O5S
- Structure:
- Chemical Name:
- Sulopenem
- CAS:
- 120788-07-0
- MF:
- C12H15NO5S3
- Structure:
- Chemical Name:
- Sultamicillin
- CAS:
- 76497-13-7
- MF:
- C25H30N4O9S2
- Structure:
- Chemical Name:
- Faropenem sodium
- CAS:
- 122547-49-3
- MF:
- C12H14NO5S.Na
- Structure:
- Chemical Name:
- Thienamycin
- CAS:
- 59995-64-1
- MF:
- C11H16N2O4S
- Structure:
- Chemical Name:
- TRANS-4-HYDROXY-1-(4-NITROBENZYLOXYCARBONYL)-L-PROLINE
- CAS:
- 96034-57-0
- MF:
- C13H14N2O7
- Structure:
- Chemical Name:
- TEBIPENEM PIVOXIL
- CAS:
- 161715-24-8
- MF:
- C22H31N3O6S2
- Structure:
- Chemical Name:
- Clavulanic acid
- CAS:
- 58001-44-8
- MF:
- C8H9NO5