Cefozopran
Cefozopran Basic information
- Product Name:
- Cefozopran
- Synonyms:
-
- CEFOZOPRAN
- sce2787
- SCE2787;SCE 2787
- Cefozopran(SCE 2787)
- 1-[[(6R,7R)-7-[[(2Z)-(5-Amino-1,2,4-thiadiazol-3-yl)(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-imidazo[1,2-b]pyridazinium hydroxide inner salt
- 1-[[(6R,7R)-7-[[2Z)-(5-Amino-1,2,4-thiadiazol-3-yl)(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]imidazo[1,2-b]pyridazinium Inner Salt
- Firstci
- SCE-1787
- CAS:
- 113359-04-9
- MF:
- C19H17N9O5S2
- MW:
- 515.52
- EINECS:
- 601-249-3
- Product Categories:
-
- Antibacterial
- Intermediates & Fine Chemicals
- Cefozopran Hydrochloride and its intermediates
- Pharmaceuticals
- Mol File:
- 113359-04-9.mol
Cefozopran Chemical Properties
- Melting point:
- >300°C
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- CAS DataBase Reference
- 113359-04-9(CAS DataBase Reference)
Cefozopran Usage And Synthesis
Chemical Properties
White To Pale-Yellow Powder
Uses
Antibacterial
Definition
ChEBI: Cefozopran is a fourth-generation cephalosporin antibiotic having imidazo[1,2-b]pyridazin-1-ium-1-ylmethyl and [(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino side groups located at positions 3 and 7 respectively. It is a cephalosporin, a member of thiadiazoles and an imidazopyridazine.
Antimicrobial activity
An aminothiazole cephalosporin formulated as the hydrochloride.
Activity is similar to that of ceftazidime, but it is more
active against methicillin-susceptible staphylococci (MIC 1
mg/L). Representative MICs against Gram-negative species
are: Esch coli 0.25 mg/L; K. pneumoniae 1 mg/L; Ps. aeruginosa
1–8 mg/L. Activity against Acinetobacter spp., Sten. maltophilia
and B. fragilis group is poor.
A 20-min infusion of 1.5 g achieved a plasma concentration
of around 125 mg/L at the end of infusion. Almost 90%
of the dose was excreted in the urine over 24 h. The mean terminal
half-life was around 2 h. Adverse reactions appear to be
typical of those of other group 6 cephalosporins.
It is available in Japan.
Cefozopran Preparation Products And Raw materials
Raw materials
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Cefozopran(113359-04-9)Related Product Information
- Thioacetamide
- N-Acetyl-L-cysteine
- Acetyl coenzyme A sodium salt
- Acetamide
- Acetylacetone
- 6-Aminocaproic acid
- ALTRENOGEST
- Glycine
- Acetyl chloride
- N,N-Dimethylacetamide
- Tris(hydroxymethyl)aminomethane
- DIACETAMIDE
- Cefazolin
- 2,1,3-Benzothiadiazole
- Acetaminophen
- 2-Mercapto-5-methyl-1,3,4-thiadiazole
- Cefotetan
- 1-[[(6R,7R)-7-[[(2Z)-(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-5,6,7,8-tetrahydro-quinolinium inner salt