Basic information Safety Supplier Related

niga-ichigoside F1

Basic information Safety Supplier Related

niga-ichigoside F1 Basic information

Product Name:
niga-ichigoside F1
Synonyms:
  • niga-ichigoside F1
  • Urs-12-en-28-oic acid, 2,3,19,23-tetrahydroxy-, β-D-glucopyranosyl ester, (2α,3β,4α)-
  • DotoriosideII
CAS:
95262-48-9
MF:
C36H58O11
MW:
666.843
Mol File:
95262-48-9.mol
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niga-ichigoside F1 Chemical Properties

Melting point:
232-234 °C
Boiling point:
775.0±60.0 °C(Predicted)
Density 
1.35±0.1 g/cm3(Predicted)
pka
12.52±0.70(Predicted)
form 
Solid
color 
White to off-white
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niga-ichigoside F1 Usage And Synthesis

Uses

Niga-ichigoside F1, an orally active ursane triterpenoid, has antihyperlipidemic and antioxidant activities. Niga-ichigoside F1 can prevent high-fat diet (HFD)-induced hepatic steatosis[1].

Definition

ChEBI: 19alpha-hydroxyasiatic acid-28-O-beta-D-glucopyrannoside is a triterpenoid saponin that is 19alpha-hydroxyasiatic acid attached to a beta-D-glucopyranosyl residue at position 28 via a glycosidic linkage. It has been isolated from the leaves of Rosa laevigata. It has a role as a plant metabolite. It is a triterpenoid saponin, a pentacyclic triterpenoid, a monosaccharide derivative, a beta-D-glucoside and a tetrol. It is functionally related to a 19alpha-hydroxyasiatic acid. It derives from a hydride of an ursane.

in vivo

Niga-ichigoside F1 (40 mg/kg; oral gavage; for 12 weeks) alleviates hepatic steatosis, possibly by significantly interacting with high-fat diet (HFD) to regulate lipid metabolism genes (including Srebp1c, Acc1, Fasn, Scd1, Cpt1a and Fabp5) in four-week-old male C57BL/6J mice[1].

References

[1] Shu-Fang Xia, et al. Niga-ichigoside F1 ameliorates high-fat diet-induced hepatic steatosis in male mice by Nrf2 activation. Food Funct. 2018 Feb 21;9(2):906-916. DOI:10.1039/c7fo01051f

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