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Bromisoval

Basic information Safety Supplier Related

Bromisoval Basic information

Product Name:
Bromisoval
Synonyms:
  • RARECHEM AX KI 5046
  • 1-(2-BROMOISOVALERYL)UREA
  • A-(BROMOISOVALERYL)UREA
  • ALPHA(BROMOISOVALERYL)UREA
  • LABOTEST-BB LT00134620
  • BROMOVALERYLUREA
  • BROMOISOVALERYLUREA
  • BROMO-ISO-VALERYLUREA (ALPHA)
CAS:
496-67-3
MF:
C6H11BrN2O2
MW:
223.07
EINECS:
207-825-7
Product Categories:
  • API
Mol File:
496-67-3.mol
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Bromisoval Chemical Properties

Melting point:
152 °C
Density 
1.6005 (rough estimate)
refractive index 
1.5410 (estimate)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
10.54±0.70(Predicted)
color 
White to Off-White
Water Solubility 
19.03g/L(temperature not stated)
Merck 
14,1397
InChIKey
CMCCHHWTTBEZNM-UHFFFAOYSA-N
CAS DataBase Reference
496-67-3(CAS DataBase Reference)
NIST Chemistry Reference
Bromisovalum(496-67-3)
EPA Substance Registry System
Butanamide, N-(aminocarbonyl)-2-bromo-3-methyl- (496-67-3)
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Safety Information

RTECS 
YS3150000
HS Code 
2924.19.8000
Toxicity
LD50 in male mice (mmoles/kg): 3.25 i.p. (Mrongovius)
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Bromisoval Usage And Synthesis

Chemical Properties

White Solid

Originator

Bromisovalum,Linhai Duqiao Fine Chemical Factory

Uses

2-Bromo-3-methylbutyrylurea is a hypnotic and sedative drug marketed over the counter in Asian under various brand names.

Definition

ChEBI: An N-acylurea that is urea in which one of the hydrogens is replaced by a 2-bromo-3-methybutanoyl group.

Manufacturing Process

A mixture of 2 kg 2-bromoisovalerylbromide and 1 kg dry urea is heated at 70°C. Then to the reaction mixture is added sodium hydrogen carbonate. 2- Bromo-3-methylbutyrylurea is recrystallized from toluene or water, melting point 149°C.

brand name

Bromural (Knoll).

Therapeutic Function

Sedative, Hypnotic

World Health Organization (WHO)

Bromisoval is a monureide sedative of long standing. It remains available in several countries. However, it releases the bromide ion and prolonged usage can result in chronic bromide accumulation and intoxication.

Safety Profile

Moderately toxic by ingestion. Human systemic effects by ingestion: nausea or vomiting, and coma. A sedative and hypnotic agent. When heated to decomposition it emits very toxic fumes of Brand NOx

Purification Methods

Crystallise it from aqueous EtOH or toluene, and dry it in air. [Beilstein 3 H 63, 3 I 29, 3 II 51, 3 III 123, 3 IV 117.]

Bromisoval Preparation Products And Raw materials

Raw materials

BromisovalSupplier

Shanghai Boyle Chemical Co., Ltd.
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