Bromisoval Chemical Properties

Melting point:

152 °C

Density 

1.6005 (rough estimate)

refractive index 

1.5410 (estimate)

storage temp. 

Sealed in dry,Room Temperature

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

pka

10.54±0.70(Predicted)

color 

White to Off-White

Water Solubility 

19.03g/L(temperature not stated)

Merck 

14,1397

InChIKey

CMCCHHWTTBEZNM-UHFFFAOYSA-N

CAS DataBase Reference

496-67-3(CAS DataBase Reference)

NIST Chemistry Reference

Bromisovalum(496-67-3)

EPA Substance Registry System

Butanamide, N-(aminocarbonyl)-2-bromo-3-methyl- (496-67-3)

Safety Information

RTECS 

YS3150000

HS Code 

2924.19.8000

Toxicity

LD50 in male mice (mmoles/kg): 3.25 i.p. (Mrongovius)

Bromisoval Usage And Synthesis

Chemical Properties

White Solid

Originator

Bromisovalum,Linhai Duqiao Fine Chemical Factory

Uses

2-Bromo-3-methylbutyrylurea is a hypnotic and sedative drug marketed over the counter in Asian under various brand names.

Definition

ChEBI: An N-acylurea that is urea in which one of the hydrogens is replaced by a 2-bromo-3-methybutanoyl group.

Manufacturing Process

A mixture of 2 kg 2-bromoisovalerylbromide and 1 kg dry urea is heated at 70°C. Then to the reaction mixture is added sodium hydrogen carbonate. 2- Bromo-3-methylbutyrylurea is recrystallized from toluene or water, melting point 149°C.

brand name

Bromural (Knoll).

Therapeutic Function

Sedative, Hypnotic

World Health Organization (WHO)

Bromisoval is a monureide sedative of long standing. It remains available in several countries. However, it releases the bromide ion and prolonged usage can result in chronic bromide accumulation and intoxication.

Safety Profile

Moderately toxic by ingestion. Human systemic effects by ingestion: nausea or vomiting, and coma. A sedative and hypnotic agent. When heated to decomposition it emits very toxic fumes of Brand NOx

Purification Methods

Crystallise it from aqueous EtOH or toluene, and dry it in air. [Beilstein 3 H 63, 3 I 29, 3 II 51, 3 III 123, 3 IV 117.]

Bromisoval(496-67-3)Related Product Information

• Hydantoin
• Amytal sodium
• Propionyl bromide
• Isoamyl nitrite
• 3-Methyl-1-butanol
• ISOVALERIC ANHYDRIDE
• Urea
• Isovaleric acid
• 3-Methyl-1-butene
• 3-Methyl-2-buten-1-ol
• Bromine
• Amobarbital
• Isoamyl nitrate γ-Methylbutyl nitrate
• 1-Bromo-2-methylpropane
• 2-BROMO-3-METHYLBUTANE
• GRANULAR UREA
• Bromisoval
• isopentyl-ure