ANTI-CALPASTATIN
ANTI-CALPASTATIN Basic information
- Product Name:
- ANTI-CALPASTATIN
- Synonyms:
-
- Monoclonal Anti-Calpastatin antibody produced in mouse
- Anti-Calpastatin antibody produced in chicken
- ANTI-CALPASTATIN, DOMAIN IV MOUSE MAB
- ANTI-CALPASTATIN
- ANTI-CALPASTATIN (DOMAIN II)
- ANTI-CALPASTATIN (DOMAIN IV)
- ANTI-CALPASTATIN, DOMAIN IV, BOVINE
- ANTI-CALPASTATIN, HUMAN
- MW:
- 0
- Mol File:
- Mol File
ANTI-CALPASTATIN Chemical Properties
- storage temp.
- −20°C
- form
- buffered aqueous solution
- biological source
- mouse
MSDS
- Language:English Provider:SigmaAldrich
ANTI-CALPASTATIN Usage And Synthesis
Uses
Monoclonal Anti-Calpastatin antibody produced in mouse is suitable for indirect immunofluorescence at a dilution of 1:200 and for western blotting at a dilution of 1:5,000.
General Description
Calpastatin is a protein encoded by the CAST gene in humans. Calpastatin is an endogenous inhibitor of the ubiquitous calcium dependent proteinases μ- and m-calpain. It plays a key role in many cellular physiological and pathological processes. Calpastatin level is very important for controlling calpain activity.
Biochem/physiol Actions
Calpastatin availability in cytosol is controlled by Ca2+ and cyclic AMP. Prolonged calpain activation promotes degradation of calpastatin. Calpastatin is found to be overexpressed in mycoplasma-contaminated cultured cells. CAST gene is found to be involved in genetic susceptibility to Keratoconus (KC), a genetically heterogeneous corneal dystrophy. It is also found to be associated with Parkinson′s disease (PD) and single nucleotide polymorphisms (SNPs).