1'-HYDROXYMIDAZOLAM Chemical Properties

Melting point:

264-266oC

Boiling point:

540.6±60.0 °C(Predicted)

Density 

1.43±0.1 g/cm3(Predicted)

Flash point:

9℃

storage temp. 

2-8°C

solubility 

DMF: 2 mg/ml; DMSO: 1 mg/ml

form 

A crystalline solid

pka

13.59±0.10(Predicted)

color 

white or off-white

Safety Information

Hazard Codes 

F,T

Risk Statements 

11-23/24/25-39/23/24/25

Safety Statements 

7-16-36/37-45

RIDADR 

UN1230 - class 3 - PG 2 - Methanol, solution

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

1'-HYDROXYMIDAZOLAM Usage And Synthesis

Description

1''-hydroxy Midazolam is the major metabolite of the anesthetic, midazolam. It is produced rapidly by the actions of hepatic cytochrome P450 3A and has been shown to be equipotent to midazolam.

Chemical Properties

White Solid

Uses

CYP3A4 metabolite of midazolam

Uses

A metabolite of Midazolam (M343000).

Definition

ChEBI: 1-hydroxymidazolam is an imidazobenzodiazepine that is midazolam in which one of the hydrogens of the methyl group is substituted by a hydroxy group. It is the major metabolite of the anesthetic, midazolam. It has a role as a drug metabolite, a human blood serum metabolite and a human urinary metabolite. It is an imidazobenzodiazepine, an organochlorine compound, a member of monofluorobenzenes and an aromatic primary alcohol. It is functionally related to a midazolam.

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