LINOLEOYLETHANOLAMIDE Chemical Properties

Melting point:

38-40 °C

Boiling point:

499.1±38.0 °C(Predicted)

Density 

0.926±0.06 g/cm3(Predicted)

Flash point:

14 °C

storage temp. 

-20°C

solubility 

DMF:25.0(Max Conc. mg/mL);77.27(Max Conc. mM)
DMSO:25.0(Max Conc. mg/mL);77.27(Max Conc. mM)
Ethanol:50.0(Max Conc. mg/mL);154.55(Max Conc. mM)

form 

ethanol solution

pka

14.49±0.10(Predicted)

Stability:

Light Sensitive, Temperature Sensitive

LogP

6.003 (est)

EPA Substance Registry System

9,12-Octadecadienamide, N-(2-hydroxyethyl)-, (9Z,12Z)- (68171-52-8)

Safety Information

Hazard Codes 

F,Xi

Risk Statements 

11-36/37/38

Safety Statements 

16-26-36

RIDADR 

UN 1170 3/PG 2

WGK Germany 

1

MSDS

• Language:English Provider:SigmaAldrich

LINOLEOYLETHANOLAMIDE Usage And Synthesis

Uses

N-Linoleoylethanolamine reduces lipopolysaccharide-induced inflammation in macrophages and reduces inflammation in ameliorates 2,4-dinitrofluorobenzene-induced contact dermatitis. N-Linoleoylethanolamine inhibits NF-κB signaling and may be used as a therapeutic agent against contact dermatitis.Linoleoyl ethanolamide is an endocannabinoid detected in porcine brain.

Definition

ChEBI: An N-(long-chain-acyl)ethanolamine that is the ethanolamide of linoleic acid.

Biochem/physiol Actions

A structural analogue of the endogenous cannabinoid receptor ligand anandamide.

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