Nicosulfuron Chemical Properties

Melting point:

141-144°C

Density 

1.4126 (rough estimate)

refractive index 

1.7000 (estimate)

storage temp. 

Sealed in dry,Room Temperature

solubility 

DMSO: 50 mg/mL (121.83 mM)

pka

pKa (25°): 4.6

Stability:

Hygroscopic, Unstable in DMSO

InChIKey

RTCOGUMHFFWOJV-UHFFFAOYSA-N

CAS DataBase Reference

111991-09-4(CAS DataBase Reference)

EPA Substance Registry System

Nicosulfuron (111991-09-4)

Safety Information

Hazard Codes 

Xi,N

Risk Statements 

36/38-50/53

Safety Statements 

24/25-26-61

RIDADR 

UN 3077 9 / PGIII

WGK Germany 

1

RTECS 

US4615000

HS Code 

29350090

Hazardous Substances Data

111991-09-4(Hazardous Substances Data)

MSDS

• Language:English Provider:1-(4,6-Dimethoxypyrimidin-2-yl)-3-(3-dimethylcarbamoyl-2-pyridylsulfonyl)urea

Nicosulfuron Usage And Synthesis

Description

Nicosulfuron is a kind of herbicides belonging to the sulfonylurea family. It is a broad-spectrum herbicide that can controls many kinds of maize weeds including both annual weeds and perennial weed including Johnsongrass, quackgrass, foxtails, shattercane, panicums, barnyardgrass, sandbur, pigweed and morningglory. It is a systemic selective herbicide, being effective in killing plants near the maize. This selectivity is achieved through maize’s capability of metabolizing Nicosulfuron into harmless compound. Its mechanism of action is through inhibiting the enzyme acetolactate synthase (ALS) of the weeds, blocking the synthesis of amino acids such as valine and isoleucine, and finally inhibiting the protein synthesis and causing death of weeds.

References

http://www.agchemaccess.com/Nicosulfuron
http://pmep.cce.cornell.edu/profiles/extoxnet/metiram-propoxur/nicosulfuron-ext.html

Chemical Properties

White Solid

Chemical Properties

White crystalline solid or powder. Phenolic odor.

Uses

Post-emergence sulfonylurea herbicide

Uses

Herbicide.

Definition

ChEBI: A N-sulfonylurea that is 2-(carbamoylsulfamoyl)-N,N-dimethylpyridine-3-carboxamide substituted by a 4,6-dimethoxypyrimidin-2-yl group at the amino nitrogen.

Agricultural Uses

Herbicide: Used as a post-emergence herbicide to control a variety of weeds on field corn and popcorn crops. Some formulations may be U.S. EPA restricted Use Pesticides (RUP). Approved for use in EU countries.

Trade name

ACCENT®; BASIS®; CELEBRITY®; CHALLENGER®; DASUL®; DPX 79406® Herbicide (with Rimsulfuron); DPX-V9636®; GHIBLI®; LAMA®; MATRIX® Herbicide (with Rimsulfuron); MILAGRO®; MISTRAL®; MOTIVEL®; NISSHIN®; SAMSON®; STEADFAST® (nicosulfuron + rimsulfuron)

Potential Exposure

Nicosulfuron is a sulfonylurea postemergence herbicide used to control a variety of weeds on field corn and popcorn crops. Some formulations may be registered as United States Restricted Use Pesticides (RUP)

Metabolic pathway

In the four systems investigated, the primary degradation pathway is to yield pyridine sulfonamide and 4,6-dimethoxy-2-aminopyrimidine. The plant and its microsomal system include the hydroxylation pathway at the 4-position of the pyrimidine ring, resulting in hydrolysis products by the cleavage of the sulfonylurea linkage. In mammals, contraction or rearrangement of the sulfonylurea linkage for nicosulfuron and N- demethylated nicosulfuron yields two unique products which have the N-pyridyl-N-pyrimidyl urea moiety and result in the uracil metabolite.

Shipping

UN3077 or UN3082 Environmentally hazardous substances, liquid or solid, n.o.s., Hazard Class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required.

Incompatibilities

Slowly hydrolyzes in water, releasing ammonia and forming acetate salts. Decomposed ＞165℃.

Waste Disposal

It is the responsibility of chemical waste generators to determine the toxicity and physical properties and of a discarded chemical and to properly identify its classification and certification as a hazardous waste and to determine the disposal method. United States Environmental Protection Agency guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult and follow all regional, national, state and local hazardous waste laws to ensure complete and accurate classification and disposal methods.

Nicosulfuron(111991-09-4)Related Product Information

• 2,6-Lutidine
• 1,1-Dimethoxyethane
• Azimsulfuron
• Dimethyldimethoxysilane
• Diethoxydimethylsilane
• 4-Dimethylaminopyridine
• 2-Pyridinesulfonamide(6CI,7CI,9CI)
• 2-Amino-4,6-dihydroxypyrimidine
• 2-Aminosulfonyl-N,N-dimethylnicotinamide
• 2-Amino-4,6-dimethoxypyrimidine
• 2-Pyridinesulfonamide, 3-methyl-
• Urea
• N,N-DIMETHYLNICOTINAMIDE
• 4,6-Dimethoxypyrimidine
• Nicotinamide
• Nicosulfuron-d6
• N,N-DIMETHYL-2-MERCAPTONICOTINAMIDE
• Nicosulfuron