ETHYL 3,4-DIMETHOXYPHENYLACETATE Chemical Properties

Boiling point:

191 °C

Density 

1.084±0.06 g/cm3(Predicted)

refractive index 

1.5180

Flash point:

159-160°C/4mm

storage temp. 

Sealed in dry,Room Temperature

form 

liquid

color 

Brown

BRN 

2697968

CAS DataBase Reference

18066-68-7(CAS DataBase Reference)

EPA Substance Registry System

Benzeneacetic acid, 3,4-dimethoxy-, ethyl ester (18066-68-7)

Safety Information

TSCA 

Yes

HS Code 

2915390090

MSDS

• Language:English Provider:ALFA

ETHYL 3,4-DIMETHOXYPHENYLACETATE Usage And Synthesis

Synthesis

In a typical reaction, 3,4-dimethoxyphenylacetic acid (332 g, 0.6 mol), ethanol (1.5-2 mol), and AMA 2:3 were mixed in a provided reaction glass tube equipped with a screw cap and magnetic stirrer until a wet mixture was formed. The reaction mixture was placed in a microwave reactor (Anton Parr Monowave 300) and irradiated at 80°C for 8 min or 120°C for 20 min. Upon completion of the reaction, the mixture was cooled, diluted with dichloromethane (41 mL), filtered by gravity and the filtrate was washed with dichloromethane. Subsequently, the filtrate was washed with saturated sodium carbonate solution and water. The organic layer was separated, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give ethyl 3,4-dimethoxyphenylacetate.

References

[1] Bioorganic and Medicinal Chemistry, 2007, vol. 15, # 4, p. 1586 - 1605
[2] Journal of Organic Chemistry, 2003, vol. 68, # 3, p. 1165 - 1167
[3] Synthetic Communications, 2014, vol. 44, # 16, p. 2386 - 2392
[4] Journal of Organic Chemistry, 2010, vol. 75, # 19, p. 6549 - 6562
[5] Tetrahedron, 1997, vol. 53, # 30, p. 10555 - 10564

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