(3,4-Dimethoxyphenyl)acetic acid Chemical Properties

Melting point:

96-98 °C (lit.)

Boiling point:

293.08°C (rough estimate)

Density 

1.2166 (rough estimate)

refractive index 

1.5430 (estimate)

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

pka

pK1:4.333 (25°C)

form 

Powder

color 

White to beige

Water Solubility 

SOLUBLE

BRN 

1110282

InChIKey

WUAXWQRULBZETB-UHFFFAOYSA-N

LogP

1.242

CAS DataBase Reference

93-40-3(CAS DataBase Reference)

NIST Chemistry Reference

Acetic acid, 3,4-dimethoxyphenyl-(93-40-3)

EPA Substance Registry System

Benzeneacetic acid, 3,4-dimethoxy- (93-40-3)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

36/37/38-22-36/37

Safety Statements 

22-24/25-36/37-26-37/39

WGK Germany 

3

RTECS 

AH0675000

TSCA 

Yes

HazardClass 

IRRITANT

HS Code 

29189090

MSDS

• Language:English Provider:Homoveratric acid
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

(3,4-Dimethoxyphenyl)acetic acid Usage And Synthesis

Chemical Properties

white to beige powder

Uses

Homoveratric Acid is a dopamine metabolite that inhibits brain mitochondrial respiration via monoamine oxidase/H2O2-dependent or non-dependent pathway.

Uses

It reacts with formaldehyde in the presence of acid to give an isochromanone.

Definition

ChEBI: Homoveratric acid is a phenylacetic acid substituted at positions 3 and 4 by methoxy groups. It has a role as a human urinary metabolite and a human xenobiotic metabolite. It is a dimethoxybenzene and a member of phenylacetic acids.

Synthesis Reference(s)

Organic Syntheses, Coll. Vol. 2, p. 333, 1943
The Journal of Organic Chemistry, 15, p. 548, 1950 DOI: 10.1021/jo01149a016

Purification Methods

Crystallise homoveratric acid from H2O or *C6H6/ligroin. The amide has m 142o (from H2O). [Beilstein 10 H 409, 10 I 197, 10 II 268, 10 III 1459, 10 IV 1509.]

(3,4-Dimethoxyphenyl)acetic acid(93-40-3)Related Product Information

• 1,3-Dimethoxybenzene
• Folic acid
• Citric acid
• Dimethoxymethane
• Glycine
• 2,6-Dimethoxybenzaldehyde
• Diphenyldimethoxysilane
• 4-Methoxyphenylacetic acid
• (R)-(-)-alpha-Methoxyphenylacetic acid
• Ethyl acetate
• 3,4-Dimethoxybenzoic acid
• 3,4-Dimethoxyphenol
• Ethyl 2-(Chlorosulfonyl)acetate
• Dimethyldimethoxysilane
• 1,1-Dimethoxyethane
• 3,4-Dimethoxyphenethylamine
• Ascoric Acid
• (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride