propyl 4-diethylcarbamoylmethoxy-3-methoxyphenylacetate Chemical Properties

Boiling point:

bp0.7 210-212°

Density 

1.2043 (rough estimate)

refractive index 

1.5000 (estimate)

storage temp. 

Refrigerator

solubility 

DMSO (Slightly), Ethyl Acetate (Slightly)

form 

Oil

color 

Pale Yellow to Yellow

EPA Substance Registry System

Propanidid (1421-14-3)

Safety Information

Toxicity

LD50 orally in rats: >10,000 mg/kg (Goldenthal)

propyl 4-diethylcarbamoylmethoxy-3-methoxyphenylacetate Usage And Synthesis

Chemical Properties

yellow oil bp0.7 210-212°C soluble in alcohol, chloroform, essentially water insoluble anasthetic Epontol (Bayer) Sombrevin

Uses

Anesthetic (intravenous).

Uses

Sombrevin, is an ultra short-acting phenylacetate general anesthetic.

Definition

ChEBI: Propanidid is a member of methoxybenzenes.

brand name

Epontol (Farbenfabriken Bayer A.G., Germany).

Clinical Use

Propanidid is used as a very short- to shortacting intravenous anesthetic for minor surgery and gynecology. It is characterized by rapid onset of and quick recovery from anesthesia, producing surgical anesthesia for 3 – 4 min. Repeated injections can be used to prolong the anesthesia. Postanesthetic sleep does not occur because the propyl ester is hydrolyzed rapidly in the patient to form inactive 3-methoxy-4- (N,N-diethylcarbamoylmethoxy)phenylacetic acid. After 20 – 30 min the patients generally are completely responsive .

Synthesis

Propanidid , propyl 3- methoxy-4-(N,N-diethylcarbamoylmethoxy)- phenylacetate, is a colorless to pale yellowish water-insoluble oil. It is prepared from the propyl ester of sodium homovanillic acid and N,N-diethylchloroacetamide .

propyl 4-diethylcarbamoylmethoxy-3-methoxyphenylacetate(1421-14-3)Related Product Information

• ETHYL 4-METHOXYPHENYLACETATE
• METHYL HOMOVERATRATE
• 2-(3,4-Dimethoxyphenyl)ethanol
• ETHYL HOMOVANILLATE
• ETHYL 4-ETHOXYPHENYLACETATE
• (3,4-Dimethoxyphenyl)acetic acid
• ETHYL 3-METHOXYPHENYLACETATE
• Methyl 4-hydroxyphenylacetate
• Homovanillic acid
• ETHYL 3,4-DIMETHOXYPHENYLACETATE
• 2-(2-METHOXYPHENOXY)ACETAMIDE
• 4-ETHOXYPHENYLACETIC ACID
• propyl 4-diethylcarbamoylmethoxy-3-methoxyphenylacetate
• 3,4-DIHYDROXYPHENYLACETIC ACID METHYL ESTER
• 4-Ethoxy-3-methoxyphenylacetic acid
• ETHYL 3,4-DIHYDROXYPHENYLACETATE
• methyl 4-hydroxy-3-methoxyphenylacetate
• 4-ethoxy-3-methoxyphenethyl alcohol