(3aS)-4,8-Dimethyl-3-methylene-4β-ethenyl-3aβ,4,5,8bβ-tetrahydrobenzo[1,2-b:3,4-b']difuran-2(3H)-one Chemical Properties

Melting point:

118-121℃

Boiling point:

378.8±42.0 °C(Predicted)

Density 

1.16±0.1 g/cm3 (20 ºC 760 Torr)

solubility 

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

form 

Powder

color 

White to off-white

(3aS)-4,8-Dimethyl-3-methylene-4β-ethenyl-3aβ,4,5,8bβ-tetrahydrobenzo[1,2-b:3,4-b']difuran-2(3H)-one Usage And Synthesis

Chemical Properties

Off-white needle-like crystals, soluble in methanol, ethanol, DMSO and other organic solvents, from Camphoraceae (Lauraceae) Uva Ursi Lindera strychnifolia Vill. root fine trace Neolitsea aciculata Koidz. root, trunk NANRENSHAN NEW WOOD JIANG ZI Neolitsea Roots of Neolitsea villosa (Blume) Merr.

Uses

Isolinderalactone suppresses human glioblastoma growth and angiogenic activity through the inhibition of VEGFR2 activation in endothelial cells[1]. Isolinderalactone suppresses the expression of B-cell lymphoma 2 (Bcl-2), survi

Definition

ChEBI: Isolinderalactone is a member of benzofurans. It has a role as a metabolite.

IC 50

VEGFR2; Bcl-2

References

[1] Park JH, et al. Isolinderalactone suppresses human glioblastoma growth and angiogenic activity in 3D microfluidic chip and in vivo mouse models.?Cancer Lett. 2020;478:71-81. DOI:10.1016/j.canlet.2020.03.009
[2] Hwang JY, et al. Isolinderalactone regulates the BCL-2/caspase-3/PARP pathway and suppresses tumor growth in a human glioblastoma multiforme xenograft mouse model.?Cancer Lett. 2019;443:25-33. DOI:10.1016/j.canlet.2018.11.027

(3aS)-4,8-Dimethyl-3-methylene-4β-ethenyl-3aβ,4,5,8bβ-tetrahydrobenzo[1,2-b:3,4-b']difuran-2(3H)-one(957-66-4)Related Product Information

• 3-Methyl-1-butanol
• Polycaprolactone