Benzyl 2-chloroacetate Chemical Properties

Boiling point:

90 °C/1 mmHg (lit.)

Density 

1.215 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.525(lit.)

Flash point:

>230 °F

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

clear liquid

Specific Gravity

1.215

color 

Oil

Water Solubility 

insoluble

CAS DataBase Reference

140-18-1(CAS DataBase Reference)

EPA Substance Registry System

Acetic acid, chloro-, phenylmethyl ester (140-18-1)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-37/39

WGK Germany 

3

RTECS 

AF8750000

HS Code 

29154000

Toxicity

LDLo ipr-mus: 500 mg/kg CBCCT* 8,99,56

MSDS

• Language:English Provider:Benzyl 2-chloroacetate
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich

Benzyl 2-chloroacetate Usage And Synthesis

Chemical Properties

Benzyl 2-chloroacetate is a colorless, slightly viscous liquid. Insoluble in water, soluble in alcohol and oils. Sp.Gr = 1.22. Mild, Jasmin-type odor, floral-fruity, of considerable tenacity.

Uses

Benzyl chloroacetate may be used:

• in the synthesis of monoesters of phosphonoacetic acid
• in the synthesis of N-benzoyl-glycyl- hydroxyl acetic acid, ester substrate for carboxypeptidase Y catalyzed peptide synthesis
• as reagent in the total syntheses of the (±)-di-O-methyl ethers of the norlignans sequirin-A, agatharesinol, and hinokiresinol, and of (±)-tri-O-methyl sequirin-E

Preparation

From Benzyl alcohol and Monochloroacetic acid by direct esterification under azeotropic conditions.

General Description

Benzyl chloroacetate is an ester. Could find usc in Jasmin, Lilac. Appleblossom fragrances, particularly for soap, where this ester has greater fixative effect than the Benzyl acetate. However, this ester must be absolutely acid-free to be permitted or recommended for use in any cosmetic product. The acid is highly corrosive. Older odor-descriptions of this ester seem to indicate that the product has not always been very pure.

Safety Profile

Moderately toxic byintraperitoneal route. When heated todecomposition it emits toxic fumes of Cl^- .

Benzyl 2-chloroacetate(140-18-1)Related Product Information

• Chloroacetic acid
• Benzyl acetate
• Benzyl 2-chloroacetate
• Benzyl2-chloro-2-[2-(4-methylphenyl)hydrazono]acetate
• 3,4-DICHLORO-5-PHENYL-2(5H)-FURANONE
• Benzyl 2-chloro-2-[2-(3,5-
• Benzyl 2-chloro-2-[2-(4-
• Benzyl 2-chloro-2-[2-(3,4-
• 1-phenylethyl 2-chloroacetoacetate
• Benzyl 2-[2-(4-bromophenyl)hydrazono]-2-
• AURORA KA-5058
• BENZYL CHLOROFLUOROACETATE
• AURORA KA-1002
• AURORA KA-996
• BUTTPARK 60\40-55
• Benzyl 2-chloro-2-[2-(3-
• SALOR-INT L132187-1EA
• Benzyl 2-chloro-2-[2-(2,6-