Lumacaftor (VX-809)
Lumacaftor (VX-809) Basic information
- Product Name:
- Lumacaftor (VX-809)
- Synonyms:
-
- 3-(6-{[1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecarbonyl]-amino}-3-methyl-pyridin-2-yl)-benzoicacid
- VX-809
- 3-[6-[[[1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl]amino]-3-methyl-2-pyridinyl]benzoic acid
- Lumacaftor
- 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxaMido)-3-Methylpyridin-2-yl)benzoic acid
- VRT 826809
- CS-719
- Lumacaftor(vx-809,vx809)
- CAS:
- 936727-05-8
- MF:
- C24H18F2N2O5
- MW:
- 452.41
- Product Categories:
-
- Inhibitors
- VX-809
- Mol File:
- 936727-05-8.mol
Lumacaftor (VX-809) Chemical Properties
- Melting point:
- 200-205oC
- Boiling point:
- 653.0±55.0 °C(Predicted)
- Density
- 1.51
- storage temp.
- -20°C Freezer
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 3.95±0.10(Predicted)
- form
- Solid
- color
- White to Off-White
Lumacaftor (VX-809) Usage And Synthesis
Uses
VX 809 is used in the stabilization of the CFTR protein used in the treatment of cystic fibrosis.
Definition
ChEBI: An aromatic amide obtained by formal condensation of the carboxy group of 1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropane-1-carboxylic acid with the aromatic amino group of 3-(6-amino-3-methylpyridin-2-yl)benzoic acid. Used for the treatment of cystic fi rosis.
Biological Activity
vx-809 is a cftr corrector that partially restores the function of f508del-cftr. in fischer rat thyroid (frt) cells, it increases f508del-cftr maturation at ec50 of 0.1 μm, and elevates f508del-cftr–mediated chloride transport at ec50 of 0.5 μm [1]. it has no effect of other ion channels (herg), transporter (p-gp) and disease-causing mislocalized proteins (α1-antitrypsin z mutant) [1]. vx-809 stabilizes n-terminal fragment of cftr that contain msd1 by altering its protein conformation [2, 3].homozygous f508del-cftr is the most common mutation in cystic fibrosis (cf) patients, accounting for 66–70% of cf cases worldwide. in cultured human bronchial epithelial cells that are homozygous for f508del, vx-809 restored the cftr function and improved chloride and fluid transport [1]. the combination of cftr potentiators and vx-809 further improved the function of f508del-cftr [4].vx-809 has been tested in several
target
CFTR
Lumacaftor (VX-809)Supplier
- Tel
- 021-58359326 13124831025
- angsihuaxue@126.com
- Tel
- 0311-67591193 15030197620
- sales02@dingminpharma.com
- Tel
- 13889821340
- tongyuansu@126.com
- Tel
- sales@boylechem.com
- Tel
- 010-82848833 400-666-7788
- jkinfo@jkchemical.com
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