ANTI-ALPHA-ACTININ Antibody
ANTI-ALPHA-ACTININ Antibody Basic information
- Product Name:
- ANTI-ALPHA-ACTININ Antibody
- Synonyms:
-
- ALPHA-ACTININ (AB-1) MONOCLONAL ANTIBODY
- Anti-α-Actinin antibody produced in rabbit
- Monoclonal Anti-α-Actinin antibody produced in mouse
- ANTI-ACTIN (SMOOTH MUSCLE)
- ANTI-ACTIN, SMOOTH MUSCLE (AB-2)
- ANTI-ACTIN, ALPHA-, HUMAN, SMOOTH MUSCLE
- ANTI-ACTININ, ALPHA
- ANTI-ACTIN-ALPHA (SMOOTH MUSCLE, HUMAN)
- MW:
- 0
- Product Categories:
-
- Antibodies to Actin-associated Proteins/MyosinCardiac Stem Cell Biology
- A1-ALCell Biology
- Alphabetical Index
- Antibodies
- Antibodies to Cytoskeleton
- Cardiac Stem Cell Tracking
- Cardiogenesis Markers
- BCardiac Stem Cell Biology
- Antibodies to Actin-associated Proteins/MyosinAntibodies
- Clone Index
- Mol File:
- Mol File
ANTI-ALPHA-ACTININ Antibody Chemical Properties
- storage temp.
- −20°C
- biological source
- rabbit
MSDS
- Language:English Provider:SigmaAldrich
ANTI-ALPHA-ACTININ Antibody Usage And Synthesis
Uses
May be used in the study of skeletal muscle organization and in studies of the membrane anchorage sites of actin.
General Description
α-actinin is a 100kD actin binding protein found in muscle as well as non-muscle cells. In smooth muscle, α-actinin is identified in dense bodies and plaques characteristic of tissues whereas it is associated with z-discs that define muscle sarcomas in normal skeletal muscle. Monoclonal anti-α-actinin antibody can be used in immunoblotting to study the membrane anchorage sites and immunochemical identification of α-actinin. It can also be used in immunofluorescence to study the localization of α-actinin in cultured cells and tissues. Mouse anti-α-actinin antibody reacts specifically with chicken fibroblasts. The product has also shown reactivity for mouse and human cells.
Biochem/physiol Actions
αactinin regulates muscle contraction and cytoskeletal organization. It promotes cell migration and acts as an actin crosslinker. Mutations in the α-actinin gene is observed in heterogeneous hypertrophic cardiomyopathy and in juvenile onset atrial fibrillation.