ALPHA-ACTININ Chemical Properties

storage temp. 

2-8°C

form 

ammonium sulfate suspension

biological source

chicken gizzard

Safety Information

WGK Germany 

3

HS Code 

3504009000

Storage Class

10 - Combustible liquids

MSDS

• Language:English Provider:SigmaAldrich

ALPHA-ACTININ Usage And Synthesis

Uses

α-Actinin from chicken gizzard has been used:

• as an antigen to coat plates for the capture of anti-actinin antibody using enzyme-linked immunosorbent assay (ELISA) from tumor cell line clones
• in in vitro motility experiments to test its effect on actin filament movement
• to coat cantilevers for strengthening fluorescently labeled actin filaments in force measurement studies

General Description

α-Actinin exists as a rod-shaped antiparallel dimer with two elongated subunits. The domain region contains an N-terminal actin-binding domain with tandem calponin homology domains, a central tandem 3-helix motifs, and EF-hand motifs at C-terminus. It belongs to the spectrin superfamily and is localized in actin structures.

Biochem/physiol Actions

α-Actinin binds actin and has the ability to crosslink actin cytoskeleton. It also plays a key role in the structural maintenance of the Z-disk of striated muscle.

ALPHA-ACTININ(11003-00-2)Related Product Information

• Aluminum acetylacetonate
• SALCOMINE
• Ethyl isocyanoacetate
• COBALT(II) ACETYLACETONATE
• METHYL ISOCYANOACETATE
• TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III)
• Tris(2,4-pentanedionato)chroMiuM(III)
• TERT-BUTYL ISOCYANIDE
• Ferric acetylacetonate
• Cupric acetylacetonate
• N-BUTYLISOCYANIDE
• DICHLORO(ETHYLENEDIAMINE)PLATINUM(II)
• 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE
• 2,4-PENTANEDIONE, SILVER DERIVATIVE
• Tosylmethyl isocyanide
• TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III)
• Benzyl isocyanide
• ANTI-ALPHA-ACTININ Antibody