DL-Propargylglycine Chemical Properties

storage temp. 

Inert atmosphere,Room Temperature

solubility 

DMF: 20 mg/ml; DMSO: 20 mg/ml; Ethanol: 20 mg/ml; PBS (pH 7.2): 10 mg/ml

form 

A crystalline solid

DL-Propargylglycine Usage And Synthesis

Description

Hydrogen sulphide (H₂S), a naturally occurring gasotransmitter, is a potent vasodilator and pro-inflammatory mediator. DL-Propargyl glycine (PAG) is an irreversible inhibitor of the H₂S synthesizing enzyme cystathionine-γ-lyase (CSE). PAG blocks H₂S synthesis activity in rat liver preparations with an IC₅₀ value of 55 μM and abolishes the rise in plasma H₂S in anaesthetized rats induced with hemorrhagic shock. At concentrations ranging from 25-100 mg/kg, PAG can reduce H₂S-associated inflammation in rodent models of pancreatitis, oedema, and endotoxemia.

Uses

DL-Propargylglycine Hydrochloride is used in preparation of tert-Butoxycarbonyl Azide.