Z-NH-5(ethylene glycol)-acetic acid CAS#: 1449390-66-2

Z-NH-5(ethylene glycol)-acetic acid Basic information

Product Name:

Z-NH-5(ethylene glycol)-acetic acid

Synonyms:

Z-NH-5(ethylene glycol)-acetic acid
Z-NH-PEG5-CH2COOH
CBZ-NH-PEG5-acetic acid
CBZ-NH-PEG5-CH2COOH
5,8,11,14,17-Pentaoxa-2-azanonadecanedioic acid, 1-(phenylmethyl) ester
CbzNH-P5-CH2CO2H
inhibit,PROTAC Linkers,Cbz-NH-PEG-5-CH2COOH,Inhibitor,Cbz NH PEG5 CH2COOH,CbzNHPEG5CH2COOH
CbzNH-PEG5-CH2COOH/5,8,11,14,17-Pentaoxa-2-azanonadecanedioic acid, 1-(phenylmethyl) ester

CAS:

1449390-66-2

MF:

C20H31NO9

MW:

429.46

Product Categories:

PEGylated Amino Acid

Mol File:

1449390-66-2.mol

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Z-NH-5(ethylene glycol)-acetic acid Usage And Synthesis

Biological Activity

Cbz-NH-PEG5-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

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